This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provid... See more...

Aliases for KLF14 Gene

Aliases for KLF14 Gene

  • Kruppel Like Factor 14 2 3 5
  • BTEB5 2 3 4
  • Basic Transcription Element-Binding Protein 5 3 4
  • Transcription Factor BTEB5 3 4
  • Krueppel-Like Factor 14 3 4
  • BTE-Binding Protein 5 3 4
  • KLF14 5

External Ids for KLF14 Gene

Previous GeneCards Identifiers for KLF14 Gene

  • GC07M129819
  • GC07M129833
  • GC07M129874
  • GC07M130068
  • GC07M130417
  • GC07M124732

Summaries for KLF14 Gene

Entrez Gene Summary for KLF14 Gene

  • This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]

GeneCards Summary for KLF14 Gene

KLF14 (Kruppel Like Factor 14) is a Protein Coding gene. Diseases associated with KLF14 include Maturity-Onset Diabetes Of The Young. An important paralog of this gene is KLF16.

Gene Wiki entry for KLF14 Gene

Additional gene information for KLF14 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF14 Gene

Genomics for KLF14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KLF14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J130733 Promoter/Enhancer 1.1 Ensembl ENCODE 600.7 -0.5 -493 3 RNF2 KDM1A PRDM1 ZIC2 PATZ1 ZNF740 CTCF EZH2 ARNT ZBTB44 LOC105375508 KLF14 CPA2 CPA5 lnc-MEST-5 ENSG00000271522 MKLN1
GH07J130069 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.8 +663.3 663254 3.7 SP1 CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 ZNF512 RFX1 KLHDC10 NRF1 ENSG00000238072 TMEM209 KLF14 ENSG00000229196 HSALNG0061341 SSMEM1
GH07J130241 Enhancer 1.1 Ensembl ENCODE 10.3 +491.3 491317 2.2 RNF2 CTCF PRDM10 JUND MTA2 ZSCAN4 PKNOX1 MTA1 REST RAD21 MEST CPA4 CPA2 CPA1 KLHDC10 KLF14 ENSG00000270992 lnc-CPA2-1 piR-34822-301 TMEM209
GH07J130113 Enhancer 1 Ensembl ENCODE 9.6 +620.3 620269 2.7 GATAD2A TFE3 RCOR2 FOXA1 RXRB IRF2 SP1 CEBPA SOX13 ARID3A KLHDC10 KLF14 RF00017-6624 RF00017-6625 SSMEM1
GH07J130209 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 9.7 +523.8 523816 1.2 MGA ZSCAN5C FOXA2 MYC EP400 NFIC ATF4 FEZF1 PRDM6 KLF10 ENSG00000229196 MEST KLF14 TMEM209 SSMEM1 piR-34822-301 CPA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF14

Top Transcription factor binding sites by QIAGEN in the KLF14 gene promoter:
  • C/EBPalpha
  • Egr-2
  • GATA-1
  • GATA-2
  • GATA-3
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • MyoD

Genomic Locations for KLF14 Gene

Genomic Locations for KLF14 Gene
chr7:130,730,697-130,734,207
(GRCh38/hg38)
Size:
3,511 bases
Orientation:
Minus strand
chr7:130,417,396-130,418,888
(GRCh37/hg19)
Size:
1,493 bases
Orientation:
Minus strand

Genomic View for KLF14 Gene

Genes around KLF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF14 Gene

Proteins for KLF14 Gene

  • Protein details for KLF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD94-KLF14_HUMAN
    Recommended name:
    Krueppel-like factor 14
    Protein Accession:
    Q8TD94
    Secondary Accessions:
    • A0A075B756
    • A4D1N0
    • Q19A42
    • Q19A43

    Protein attributes for KLF14 Gene

    Size:
    323 amino acids
    Molecular mass:
    33094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF14 Gene

Post-translational modifications for KLF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF14 Gene

Domains & Families for KLF14 Gene

Gene Families for KLF14 Gene

Protein Domains for KLF14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF14 Gene

GenScript: Design optimal peptide antigens:
  • Kruppel-like factor 14 (A4D1N0_HUMAN)
  • Transcription factor BTEB5 (KLF14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TD94

UniProtKB/Swiss-Prot:

KLF14_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF14: view

Function for KLF14 Gene

Phenotypes From GWAS Catalog for KLF14 Gene

Gene Ontology (GO) - Molecular Function for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with KLF14: view
genes like me logo Genes that share phenotypes with KLF14: view

Animal Models for KLF14 Gene

MGI Knock Outs for KLF14:
  • Klf14 Klf14<tm1.1(KOMP)Vlcg>
  • Klf14 Klf14<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for KLF14 Gene

miRTarBase miRNAs that target KLF14
Targeted motifs for KLF14 Gene
HOMER Transcription Factor Regulatory Elements motif KLF14
  • Consensus sequence: RGKGGGCGKGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF14 Gene

Localization for KLF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF14 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with KLF14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF14 Gene

Pathways & Interactions for KLF14 Gene

PathCards logo

SuperPathways for KLF14 Gene

No Data Available

Interacting Proteins for KLF14 Gene

Gene Ontology (GO) - Biological Process for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA,IMP 24759103
GO:1902070 positive regulation of sphingolipid mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with KLF14: view

No data available for Pathways by source and SIGNOR curated interactions for KLF14 Gene

Drugs & Compounds for KLF14 Gene

No Compound Related Data Available

Transcripts for KLF14 Gene

mRNA/cDNA for KLF14 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF14

Alternative Splicing Database (ASD) splice patterns (SP) for KLF14 Gene

No ASD Table

Relevant External Links for KLF14 Gene

GeneLoc Exon Structure for
KLF14

Expression for KLF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF14 Gene

This gene is overexpressed in Whole Blood (x15.9), Testis (x5.6), and Adrenal Gland (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF14

SOURCE GeneReport for Unigene cluster for KLF14 Gene:

Hs.125240

Evidence on tissue expression from TISSUES for KLF14 Gene

  • Blood(2.3)
  • Muscle(2.2)
  • Pancreas(2.2)
  • Liver(2.2)
  • Heart(2.1)
  • Skin(2.1)
  • Nervous system(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with KLF14: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF14 Gene

Orthologs for KLF14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLF14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KLF14 30
  • 99.48 (n)
Dog
(Canis familiaris)
Mammalia KLF14 30
  • 87.72 (n)
Cow
(Bos Taurus)
Mammalia KLF14 30
  • 84.31 (n)
Rat
(Rattus norvegicus)
Mammalia Klf14 30
  • 75.73 (n)
Mouse
(Mus musculus)
Mammalia Klf14 30 17
  • 74.51 (n)
Species where no ortholog for KLF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KLF14 Gene

ENSEMBL:
Gene Tree for KLF14 (if available)
TreeFam:
Gene Tree for KLF14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF14: view image

Paralogs for KLF14 Gene

(10) SIMAP similar genes for KLF14 Gene using alignment to 2 proteins:

  • KLF14_HUMAN
  • A4D1N0_HUMAN
genes like me logo Genes that share paralogs with KLF14: view

Variants for KLF14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF14 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs35770036 - p.Ala173Pro

Additional dbSNP identifiers (rs#s) for KLF14 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF14 Gene

Variant ID Type Subtype PubMed ID
nsv1029405 CNV gain 25217958
nsv608421 CNV gain 21841781

Variation tolerance for KLF14 Gene

Gene Damage Index Score: 8.75; 86.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF14 Gene

Disorders for KLF14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mody
- elite association - COSMIC cancer census association via MalaCards
Search KLF14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KLF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF14 Gene

Publications for KLF14 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
  2. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight BF … GIANT Consortium (Nature genetics 2010) 3 41
  3. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman DI … Ridker PM (PLoS genetics 2009) 3 41
  4. New common variants affecting susceptibility to basal cell carcinoma. (PMID: 19578363) Stacey SN … Stefansson K (Nature genetics 2009) 3 41
  5. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PMID: 17480121) Parker-Katiraee L … Scherer SW (PLoS genetics 2007) 2 3

Products for KLF14 Gene

Sources for KLF14 Gene