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KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008] See more...
Aliases for KLF13 Gene
Aliases for KLF13 Gene
External Ids for KLF13 Gene
- HGNC: 13672
- Entrez Gene: 51621
- Ensembl: ENSG00000169926
- OMIM: 605328
- UniProtKB: Q9Y2Y9
Previous GeneCards Identifiers for KLF13 Gene
- GC15M027358
- GC15P024375
- GC15P029199
- GC15P029335
- GC15P028915
- GC15P031619
- GC15P008795
Summaries for KLF13 Gene
-
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
GeneCards Summary for KLF13 Gene
KLF13 (Kruppel Like Factor 13) is a Protein Coding gene. Diseases associated with KLF13 include Chromosome 15Q13.3 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is KLF16.
UniProtKB/Swiss-Prot Summary for KLF13 Gene
-
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.
Additional gene information for KLF13 Gene
- Monarch Initiative
- Search for KLF13 at DataMed
- Search for KLF13 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF13 Gene
Genomics for KLF13 Gene
GeneHancer (GH) Regulatory Elements for KLF13 Gene
Promoters and enhancers for KLF13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLF13 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KLF13 gene promoter:
-
- Nkx2-5
- p53
- Sp1
- STAT3
Genomic Locations for KLF13 Gene
Genomic Locations for KLF13 Gene
- chr15:31,326,835-31,435,665
- (GRCh38/hg38)
- Size:
- 108,831 bases
- Orientation:
- Plus strand
- chr15:31,619,058-31,727,868
- (GRCh37/hg19)
- Size:
- 108,811 bases
- Orientation:
- Plus strand
Genomic View for KLF13 Gene
Genes around KLF13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q13.3 by HGNC
- 15q13.3 by Entrez Gene
- 15q13.3 by Ensembl
KLF13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLF13 Gene
Proteins for KLF13 Gene
-
Protein details for KLF13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2Y9-KLF13_HUMAN
- Recommended name:
- Krueppel-like factor 13
- Protein Accession:
- Q9Y2Y9
- Q9Y356
Protein attributes for KLF13 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 31180 Da
- Quaternary structure:
- No Data Available
Protein Expression for KLF13 Gene
Post-translational modifications for KLF13 Gene
- Phosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for KLF13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-KLF13 (internal region) polyclonal antibody
- Novus Biologicals Antibodies for KLF13
-
Abcam antibodies for KLF13
- Invitrogen Antibodies for KLF13 (AFLGC-KLF13)
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLF13
- Sino Biological Antibodies for KLF13
Protein Products
- Creative Biomart Recombinant Human KLF13 293 Cell Lysate and Recombinant Human KLF13 Protein, GST-His-tagged
-
OriGene Purified Proteins for KLF13
- Search Origene for MassSpec and Protein Over-expression Lysates for KLF13
- Origene Custom Protein Services for KLF13
- Novus Biologicals lysates for KLF13
- antibodies-online: Show 2 available KLF13 Proteins ranked by validation data
- Compare Top KLF13 Proteins
-
Quality Products:
-
Abcam proteins for KLF13
Assay Products
- Aviva Systems Biology KLF13 ELISA Kit (Human) (OKEH04165)
- antibodies-online: Show 6 available KLF13 Elisa Kits ranked by validation data
- Compare Top KLF13 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for KLF13 Gene
Domains & Families for KLF13 Gene
Gene Families for KLF13 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for KLF13 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLF13 Gene
- GenScript: Design optimal peptide antigens:
-
- Transcription factor NSLP1 (KLF13_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y2Y9UniProtKB/Swiss-Prot:
KLF13_HUMAN :- The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
- Belongs to the Sp1 C2H2-type zinc-finger protein family.
- Domain:
-
- The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
- Family:
-
- Belongs to the Sp1 C2H2-type zinc-finger protein family.
Function for KLF13 Gene
Molecular function for KLF13 Gene
- UniProtKB/Swiss-Prot Function:
- Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.
Phenotypes From GWAS Catalog for KLF13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for KLF13 Gene
- MGI mutant phenotypes for KLF13:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KLF13:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for KLF13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLF13
- genomics-online: gRNA clones - Search for available KLF13 gRNA products
- Overview of 99 available KLF13 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KLF13 - Select products 50% OFF >
- * KLF13 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KLF13 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLF13
miRNA for KLF13 Gene
- miRTarBase miRNAs that target KLF13
-
- hsa-mir-372-3p (MIRT000060)
- hsa-mir-302d-3p (MIRT000094)
- hsa-mir-125b-5p (MIRT003421)
- hsa-mir-31-5p (MIRT004972)
- hsa-mir-125a-5p (MIRT005339)
- hsa-mir-98-5p (MIRT005676)
- hsa-mir-335-5p (MIRT018161)
- hsa-mir-1200 (MIRT071955)
- hsa-mir-1257 (MIRT071956)
- hsa-mir-3163 (MIRT071957)
- hsa-mir-4324 (MIRT071958)
- hsa-mir-4329 (MIRT071959)
- hsa-mir-3662 (MIRT071960)
- hsa-mir-4452 (MIRT071961)
- hsa-mir-4524a-3p (MIRT071963)
- hsa-mir-892c-5p (MIRT071965)
- hsa-mir-19a-3p (MIRT139915)
- hsa-mir-19b-3p (MIRT139916)
- hsa-mir-7113-5p (MIRT192333)
- hsa-mir-1-3p (MIRT192334)
- hsa-mir-206 (MIRT192335)
- hsa-mir-490-3p (MIRT192336)
- hsa-mir-613 (MIRT192337)
- hsa-mir-619-3p (MIRT192338)
- hsa-mir-6128 (MIRT192341)
- hsa-mir-8066 (MIRT192342)
- hsa-mir-4747-5p (MIRT474651)
- hsa-mir-5196-5p (MIRT474652)
- hsa-mir-766-5p (MIRT474653)
- hsa-mir-7515 (MIRT474654)
- hsa-mir-4518 (MIRT474655)
- hsa-mir-1266-5p (MIRT474656)
- hsa-mir-3664-3p (MIRT474657)
- hsa-mir-4433a-3p (MIRT474658)
- hsa-mir-4459 (MIRT474659)
- hsa-mir-4768-3p (MIRT474660)
- hsa-mir-9500 (MIRT474661)
- hsa-mir-7851-3p (MIRT474662)
- hsa-mir-7106-5p (MIRT474663)
- hsa-mir-1289 (MIRT474664)
- hsa-mir-765 (MIRT474665)
- hsa-mir-4722-5p (MIRT474666)
- hsa-mir-6124 (MIRT474667)
- hsa-mir-6837-5p (MIRT474668)
- hsa-mir-4685-5p (MIRT474669)
- hsa-mir-4756-5p (MIRT474670)
- hsa-mir-4739 (MIRT474671)
- hsa-mir-1321 (MIRT474672)
- hsa-mir-6165 (MIRT474673)
- hsa-mir-6867-5p (MIRT536459)
- hsa-mir-6793-3p (MIRT536460)
- hsa-mir-378a-5p (MIRT556784)
- hsa-mir-630 (MIRT556785)
- hsa-mir-544b (MIRT556786)
- hsa-mir-506-5p (MIRT556787)
- hsa-mir-4435 (MIRT570634)
- hsa-mir-4663 (MIRT570635)
- hsa-mir-3194-5p (MIRT570636)
- hsa-mir-3670 (MIRT570637)
- hsa-mir-3190-5p (MIRT570638)
- hsa-mir-6858-3p (MIRT570639)
- hsa-mir-4438 (MIRT570640)
- hsa-mir-6833-3p (MIRT656843)
- hsa-mir-4768-5p (MIRT656844)
- hsa-mir-556-3p (MIRT656845)
- hsa-mir-524-5p (MIRT656846)
- hsa-mir-520d-5p (MIRT656847)
- hsa-mir-2117 (MIRT656848)
- hsa-mir-6504-3p (MIRT656849)
- hsa-mir-148a-5p (MIRT656850)
- hsa-mir-6726-3p (MIRT714461)
- hsa-mir-4467 (MIRT714462)
- hsa-mir-566 (MIRT714463)
- hsa-mir-668-5p (MIRT714464)
- hsa-mir-18b-3p (MIRT714465)
- hsa-mir-6087 (MIRT714466)
- hsa-mir-4509 (MIRT714467)
- hsa-mir-1249-3p (MIRT714468)
- hsa-mir-940 (MIRT714469)
- hsa-mir-6893-5p (MIRT714470)
- hsa-mir-6808-5p (MIRT714471)
- hsa-mir-4695-5p (MIRT714472)
- hsa-mir-4755-5p (MIRT720203)
- hsa-mir-6823-3p (MIRT720204)
- hsa-mir-2114-3p (MIRT720205)
- hsa-mir-6501-3p (MIRT720206)
- hsa-mir-3614-3p (MIRT720207)
- hsa-mir-193a-5p (MIRT738568)
- hsa-mir-4251 (MIRT743317)
- hsa-mir-539-5p (MIRT750349)
- hsa-mir-541-3p (MIRT750374)
- hsa-mir-548az-5p (MIRT750650)
- hsa-mir-548t-5p (MIRT750799)
- hsa-mir-654-5p (MIRT753445)
- hsa-mir-6761-5p (MIRT754962)
- hsa-mir-6769a-5p (MIRT755187)
- hsa-mir-6769b-5p (MIRT755233)
- hsa-mir-92a-2-5p (MIRT760561)
- hsa-mir-1207-5p (MIRT761260)
- hsa-mir-2392 (MIRT764004)
- hsa-mir-4446-3p (MIRT769171)
- hsa-mir-4656 (MIRT770762)
- hsa-mir-4736 (MIRT771809)
- hsa-mir-4763-3p (MIRT772016)
- hsa-mir-6132 (MIRT775897)
- hsa-mir-6836-5p (MIRT780062)
- hsa-mir-6869-5p (MIRT780679)
- hsa-mir-7150 (MIRT781497)
- hsa-mir-8077 (MIRT782391)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KLF13
- Browse OriGene Inhibitory RNA Products For KLF13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF13
- genomics-online: shRNA clones - Search for available KLF13 shRNA products
- Overview of 99 available KLF13 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KLF13
- Addgene plasmids for KLF13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLF13
- genomics-online: cdna clones - Search for available KLF13 CDNA products
- Overview of 99 available KLF13 gene related products
- orf clones - Search for available KLF13 ORF products
- Overview of 99 available KLF13 gene related products
- Applied Biological Materials (abm): Clones for KLF13 - Select products 50% OFF >
- * KLF13 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KLF13 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for KLF13
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KLF13 Gene
Localization for KLF13 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLF13 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF13 Gene
Pathways & Interactions for KLF13 Gene
Interacting Proteins for KLF13 Gene
Selected Interacting proteins:
Q9Y2Y9-KLF13_HUMAN
ENSP00000302456
for KLF13 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for KLF13
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA,IEA | 21873635 |
| GO:0006366 | transcription by RNA polymerase II | TAS | 10023774 |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
| GO:0045647 | negative regulation of erythrocyte differentiation | IEA | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IEA | -- |
No data available for Pathways by source for KLF13 Gene
Drugs & Compounds for KLF13 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human KLF13 293 Cell Lysate and Recombinant Human KLF13 Protein, GST-His-tagged
Transcripts for KLF13 Gene
mRNA/cDNA for KLF13 Gene
- (2) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (265) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000307145 6845 bps (ENST00000307145.3)
- ENST00000558921 440 bps (ENST00000558921.1)
- ENST00000560473 489 bps (ENST00000560473.1)
- ENST00000558844 574 bps (ENST00000558844.1)
- ENST00000558673 447 bps (ENST00000558673.1)
CRISPR Products
-
OriGene CRISPR knockouts for KLF13
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLF13
- genomics-online: gRNA clones - Search for available KLF13 gRNA products
- Overview of 99 available KLF13 gene related products
- Applied Biological Materials (abm): CRISPR Clones for KLF13 - Select products 50% OFF >
- * KLF13 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * KLF13 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLF13
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for KLF13
- Browse OriGene Inhibitory RNA Products For KLF13
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLF13
- genomics-online: shRNA clones - Search for available KLF13 shRNA products
- Overview of 99 available KLF13 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KLF13
- Addgene plasmids for KLF13
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLF13
- genomics-online: cdna clones - Search for available KLF13 CDNA products
- Overview of 99 available KLF13 gene related products
- orf clones - Search for available KLF13 ORF products
- Overview of 99 available KLF13 gene related products
- Applied Biological Materials (abm): Clones for KLF13 - Select products 50% OFF >
- * KLF13 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * KLF13 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for KLF13 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Thymus (Hematopoietic System)
This gene is overexpressed in Peripheral blood mononuclear cells (18.3), Retina (11.4), Lung (9.1), and Heart (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLF13 Gene
NURSA nuclear receptor signaling pathways regulating expression of KLF13 Gene:
KLF13SOURCE GeneReport for Unigene cluster for KLF13 Gene:
Hs.525752mRNA Expression by UniProt/SwissProt for KLF13 Gene:
Q9Y2Y9-KLF13_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for KLF13 Gene
- Lung(4.3)
- Pancreas(4.3)
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs for KLF13
-
OriGene qPCR primer pairs and template standards for KLF13
- genomics-online: primer clones - Search for available KLF13 Primer products
- Overview of 99 available KLF13 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF13 Gene
Orthologs for KLF13 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KLF13 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KLF13 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Klf13 32 |
|
||
| cow (Bos Taurus) |
Mammalia | KLF13 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Klf13 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KLF13 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KLF13 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KLF13 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | klf13 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | klf13 33 32 |
|
OneToOne | |
| wufi22b08 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | EP2237 34 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | Y40B1A.4 34 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7373 33 |
|
OneToMany |
- Species where no ortholog for KLF13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for KLF13 Gene
- ENSEMBL:
- Gene Tree for KLF13 (if available)
- TreeFam:
- Gene Tree for KLF13 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLF13: view image
Paralogs for KLF13 Gene
Paralogs for KLF13 Gene
(136) SIMAP similar genes for KLF13 Gene using alignment to 3 proteins:
- KLF13_HUMAN
- H0YK05_HUMAN
- H0YKM8_HUMAN
- DKFZp686O1631
- KLF7
- SP3
- KLF9
- KLF1
- ZNF500
- DKFZp686N0199
- WT1
- ZNF18
- ZNF83
- ZNF19
- KLF8
- HKR1
- ZNF263
- KLF4
- kr-znf3
- KLF16
- ZNF696
- ZNF304
- SP4
- A-328A3.4
- ZNF78L1
- ZNF671
- ZNF665
- ZNF606
- ZNF567
- ZNF544
- ZNF480
- ZNF479
- ZNF426
- ZNF417
- ZNF26
- ZNF213
- ZNF133
- ZNF10
- GTF3A
- ZNF697
- ZNF888
- ZNF84
- ZNF726
- ZNF7
- ZNF211
- KLF6
- ZNF850
- ZNF79
- ZNF708
- ZNF562
- ZNF205
- ZNF195
- OSR2
- PRDM9
- ZNF72
- ZNF728
- ZNF626
- ZNF585B
- ZNF566
- ZNF551
- ZNF473
- ZNF420
- ZNF112
- SP2
- PRMD9
- SP1
- CTCFL
- ZNF737
- ZNF565
- ZNF254
- VEZF1
- MYNN
- ZNF85
- ZNF702P
- ZNF720
- ZNF66
- ZNF587B
- ZNF418
- ZNF384
- ZNF160
- ZFP1
- Sp1
- SP8
- PRDM15
- IKZF2
- GZF1
- ZNF236
- ZNF
- REST
- ZNF410
- ZSCAN10
- ZNF841
- ZNF768
- ZNF569
- ZNF536
- ZNF253
- ZIK1
- ZNF770
- ZFS-6
- ZSCAN5A
- ZNF653
- ZNF649
- ZNF615
- ZNF517
- ZNF341
- ZNF324
- MAZ
- DKFZp434J0650
- ZNF808
- ZNF219
- ZIC1
- ZNF878
- ZNF711
- ZNF628
- ZNF550
- ZNF529
- ZNF423
- ZNF345
- ZNF285
- ZNF283
- SP9
- BCL6B
- ZNF672
- ZNF55
- ZNF791
- ZNF700
- ZNF34
- PRDM10
- ZNF223
- FIZ1
- KLF14
- ZSCAN9
- SALL2
- ZFS-5
- ZNF584
- ZBTB44
- ZBTB38
- SP6
- E4F1
Variants for KLF13 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000023945 | -- | 31,399,542(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000063088 | -- | 31,355,646(+) | G/A | intron_variant | |
| rs1000076300 | -- | 31,399,308(+) | A/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000078509 | -- | 31,353,167(+) | T/C | intron_variant | |
| rs1000086185 | -- | 31,361,271(+) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4429n54 | CNV | loss | 21841781 |
| dgv4430n54 | CNV | loss | 21841781 |
| dgv4431n54 | CNV | gain+loss | 21841781 |
| dgv4432n54 | CNV | gain | 21841781 |
| dgv4433n54 | CNV | gain | 21841781 |
| dgv4434n54 | CNV | loss | 21841781 |
| esv29856 | CNV | loss | 19812545 |
| esv34100 | CNV | loss | 18971310 |
| esv3636052 | CNV | gain | 21293372 |
| nsv1070262 | CNV | deletion | 25765185 |
| nsv456747 | CNV | loss | 19166990 |
| nsv456748 | CNV | loss | 19166990 |
| nsv511044 | OTHER | inversion | 20534489 |
| nsv516681 | CNV | loss | 19592680 |
| nsv568772 | CNV | loss | 21841781 |
| nsv568773 | CNV | loss | 21841781 |
| nsv568774 | CNV | gain | 21841781 |
| nsv568777 | CNV | gain+loss | 21841781 |
| nsv568781 | CNV | gain+loss | 21841781 |
| nsv568799 | CNV | gain | 21841781 |
| nsv568801 | CNV | loss | 21841781 |
| nsv827280 | CNV | gain | 20364138 |
Gene Damage Index Score:
1.65;
31.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLF13 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF13 Gene
Disorders for KLF13 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 15q13.3 deletion syndrome |
|
|
Search KLF13 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLF13
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KLF13 Gene
Publications for KLF13 Gene
- RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. (PMID: 10023774) Song A … Krensky AM (Immunity 1999) 2 3 4 56
- Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors. (PMID: 10415854) Cook T … Urrutia R (Annals of the New York Academy of Sciences 1999) 2 3 4 56
- Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells. (PMID: 18056793) Natesampillai S … Veldhuis JD (American journal of physiology. Endocrinology and metabolism 2008) 3 23 56
- Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. (PMID: 17513757) Huang B … Krensky AM (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 23 56
- A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function. (PMID: 16303770) Natesampillai S … Veldhuis JD (The Journal of biological chemistry 2006) 3 23 56
ExternalLinks
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Sources for KLF13 Gene
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