KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008] See more...

Aliases for KLF13 Gene

Aliases for KLF13 Gene

  • Kruppel Like Factor 13 2 3 5
  • Novel Sp1-Like Zinc Finger Transcription Factor 1 3 4
  • Transcription Factor BTEB3 3 4
  • Transcription Factor NSLP1 3 4
  • Krueppel-Like Factor 13 3 4
  • BTE-Binding Protein 3 3 4
  • RFLAT-1 3 4
  • BTEB3 3 4
  • NSLP1 3 4
  • RANTES Factor Of Late Activated T Lymphocytes-1 3
  • RANTES Factor Of Late Activated T-Lymphocytes 1 4
  • Basic Transcription Element Binding Protein 3 3
  • Basic Transcription Element-Binding Protein 3 4
  • RFLAT1 3
  • FKLF2 3

External Ids for KLF13 Gene

Previous GeneCards Identifiers for KLF13 Gene

  • GC15M027358
  • GC15P024375
  • GC15P029199
  • GC15P029335
  • GC15P028915
  • GC15P031619
  • GC15P008795

Summaries for KLF13 Gene

Entrez Gene Summary for KLF13 Gene

  • KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

GeneCards Summary for KLF13 Gene

KLF13 (Kruppel Like Factor 13) is a Protein Coding gene. Diseases associated with KLF13 include Chromosome 15Q13.3 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is KLF16.

UniProtKB/Swiss-Prot Summary for KLF13 Gene

  • Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.

Gene Wiki entry for KLF13 Gene

Additional gene information for KLF13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF13 Gene

Genomics for KLF13 Gene

GeneHancer (GH) Regulatory Elements for KLF13 Gene


GeneHancers around KLF13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLF13 gene promoter:
  • Nkx2-5
  • p53
  • Sp1
  • STAT3

Genomic Locations for KLF13 Gene

Genomic Locations for KLF13 Gene
chr15:31,326,835-31,435,665
(GRCh38/hg38)
Size:
108,831 bases
Orientation:
Plus strand
chr15:31,619,058-31,727,868
(GRCh37/hg19)
Size:
108,811 bases
Orientation:
Plus strand

Genomic View for KLF13 Gene

Genes around KLF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF13 Gene

Proteins for KLF13 Gene

  • Protein details for KLF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y9-KLF13_HUMAN
    Recommended name:
    Krueppel-like factor 13
    Protein Accession:
    Q9Y2Y9
    Secondary Accessions:
    • Q9Y356

    Protein attributes for KLF13 Gene

    Size:
    288 amino acids
    Molecular mass:
    31180 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF13 Gene

Post-translational modifications for KLF13 Gene

Other Protein References for KLF13 Gene

Antibody Products

  • Abcam antibodies for KLF13

No data available for DME Specific Peptides for KLF13 Gene

Domains & Families for KLF13 Gene

Gene Families for KLF13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF13 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor NSLP1 (KLF13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y9

UniProtKB/Swiss-Prot:

KLF13_HUMAN :
  • The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Domain:
  • The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF13: view

Function for KLF13 Gene

Molecular function for KLF13 Gene

UniProtKB/Swiss-Prot Function:
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.

Phenotypes From GWAS Catalog for KLF13 Gene

Gene Ontology (GO) - Molecular Function for KLF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KLF13: view
genes like me logo Genes that share phenotypes with KLF13: view

Human Phenotype Ontology for KLF13 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KLF13 Gene

MGI Knock Outs for KLF13:

Animal Model Products

CRISPR Products

miRNA for KLF13 Gene

miRTarBase miRNAs that target KLF13

Clone Products

  • Addgene plasmids for KLF13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KLF13 Gene

Localization for KLF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF13 gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with KLF13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF13 Gene

Pathways & Interactions for KLF13 Gene

PathCards logo

SuperPathways for KLF13 Gene

No Data Available

SIGNOR curated interactions for KLF13 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA,IEA 21873635
GO:0006366 transcription by RNA polymerase II TAS 10023774
GO:0008285 negative regulation of cell proliferation IEA --
GO:0045647 negative regulation of erythrocyte differentiation IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with KLF13: view

No data available for Pathways by source for KLF13 Gene

Drugs & Compounds for KLF13 Gene

(3) Drugs for KLF13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLF13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLF13: view

Transcripts for KLF13 Gene

mRNA/cDNA for KLF13 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for KLF13

Alternative Splicing Database (ASD) splice patterns (SP) for KLF13 Gene

No ASD Table

Relevant External Links for KLF13 Gene

GeneLoc Exon Structure for
KLF13
ECgene alternative splicing isoforms for
KLF13

Expression for KLF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.3), Retina (11.4), Lung (9.1), and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KLF13 Gene



Protein tissue co-expression partners for KLF13 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLF13 Gene:

KLF13

SOURCE GeneReport for Unigene cluster for KLF13 Gene:

Hs.525752

mRNA Expression by UniProt/SwissProt for KLF13 Gene:

Q9Y2Y9-KLF13_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for KLF13 Gene

  • Lung(4.3)
  • Pancreas(4.3)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with KLF13: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF13 Gene

Orthologs for KLF13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF13 33 32
  • 99.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLF13 33
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf13 32
  • 93.75 (n)
cow
(Bos Taurus)
Mammalia KLF13 32
  • 91.64 (n)
mouse
(Mus musculus)
Mammalia Klf13 17 33 32
  • 91.52 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF13 33
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF13 33 32
  • 60.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF13 33
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf13 32
  • 65.76 (n)
zebrafish
(Danio rerio)
Actinopterygii klf13 33 32
  • 64.91 (n)
OneToOne
wufi22b08 32
fruit fly
(Drosophila melanogaster)
Insecta EP2237 34
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea Y40B1A.4 34
  • 66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 33
  • 14 (a)
OneToMany
Species where no ortholog for KLF13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF13 Gene

ENSEMBL:
Gene Tree for KLF13 (if available)
TreeFam:
Gene Tree for KLF13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF13: view image

Paralogs for KLF13 Gene

genes like me logo Genes that share paralogs with KLF13: view

Variants for KLF13 Gene

Sequence variations from dbSNP and Humsavar for KLF13 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000023945 -- 31,399,542(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000063088 -- 31,355,646(+) G/A intron_variant
rs1000076300 -- 31,399,308(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000078509 -- 31,353,167(+) T/C intron_variant
rs1000086185 -- 31,361,271(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLF13 Gene

Variant ID Type Subtype PubMed ID
dgv4429n54 CNV loss 21841781
dgv4430n54 CNV loss 21841781
dgv4431n54 CNV gain+loss 21841781
dgv4432n54 CNV gain 21841781
dgv4433n54 CNV gain 21841781
dgv4434n54 CNV loss 21841781
esv29856 CNV loss 19812545
esv34100 CNV loss 18971310
esv3636052 CNV gain 21293372
nsv1070262 CNV deletion 25765185
nsv456747 CNV loss 19166990
nsv456748 CNV loss 19166990
nsv511044 OTHER inversion 20534489
nsv516681 CNV loss 19592680
nsv568772 CNV loss 21841781
nsv568773 CNV loss 21841781
nsv568774 CNV gain 21841781
nsv568777 CNV gain+loss 21841781
nsv568781 CNV gain+loss 21841781
nsv568799 CNV gain 21841781
nsv568801 CNV loss 21841781
nsv827280 CNV gain 20364138

Variation tolerance for KLF13 Gene

Gene Damage Index Score: 1.65; 31.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF13 Gene

Human Gene Mutation Database (HGMD)
KLF13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF13 Gene

Disorders for KLF13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF13 Gene - From: HGMD, GTR, and DISEASES

Disorder Aliases PubMed IDs
chromosome 15q13.3 deletion syndrome
  • chromosome 15q13.3 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search KLF13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF13 Gene

Publications for KLF13 Gene

  1. RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. (PMID: 10023774) Song A … Krensky AM (Immunity 1999) 2 3 4 56
  2. Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors. (PMID: 10415854) Cook T … Urrutia R (Annals of the New York Academy of Sciences 1999) 2 3 4 56
  3. Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells. (PMID: 18056793) Natesampillai S … Veldhuis JD (American journal of physiology. Endocrinology and metabolism 2008) 3 23 56
  4. Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. (PMID: 17513757) Huang B … Krensky AM (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 23 56
  5. A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function. (PMID: 16303770) Natesampillai S … Veldhuis JD (The Journal of biological chemistry 2006) 3 23 56

Products for KLF13 Gene

Sources for KLF13 Gene