Aliases for KLF13 Gene
External Ids for KLF13 Gene
Previous GeneCards Identifiers for KLF13 Gene
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
GeneCards Summary for KLF13 Gene
KLF13 (Kruppel Like Factor 13) is a Protein Coding gene. Diseases associated with KLF13 include Chromosome 15Q13.3 Deletion Syndrome and Spherocytosis, Type 2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is KLF14.
UniProtKB/Swiss-Prot for KLF13 Gene
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.