Aliases for KLF11 Gene
External Ids for KLF11 Gene
Previous HGNC Symbols for KLF11 Gene
Previous GeneCards Identifiers for KLF11 Gene
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
GeneCards Summary for KLF11 Gene
KLF11 (Kruppel Like Factor 11) is a Protein Coding gene. Diseases associated with KLF11 include Maturity-Onset Diabetes Of The Young, Type 7 and Maturity-Onset Diabetes Of The Young. Among its related pathways are TGF-beta Signaling Pathway (WikiPathways) and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is KLF10.
UniProtKB/Swiss-Prot Summary for KLF11 Gene
Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).