This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided... See more...

Aliases for KLF10 Gene

Aliases for KLF10 Gene

  • Kruppel Like Factor 10 2 3 5
  • Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1 3 4
  • TGFB-Inducible Early Growth Response Protein 1 3 4
  • Krueppel-Like Factor 10 3 4
  • EGR-Alpha 3 4
  • TIEG1 3 4
  • TIEG 3 4
  • Zinc Finger Transcription Factor TIEG 3
  • TGFB Inducible Early Growth Response 2
  • Early Growth Response-Alpha 3
  • TIEG-1 4
  • EGRA 3

External Ids for KLF10 Gene

Previous HGNC Symbols for KLF10 Gene

  • TIEG

Previous GeneCards Identifiers for KLF10 Gene

  • GC08M103731
  • GC08M103661
  • GC08M098862

Summaries for KLF10 Gene

Entrez Gene Summary for KLF10 Gene

  • This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for KLF10 Gene

KLF10 (Kruppel Like Factor 10) is a Protein Coding gene. Diseases associated with KLF10 include Hemoglobinopathy and Pancreatic Cancer. Among its related pathways are ERK Signaling and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and core promoter sequence-specific DNA binding. An important paralog of this gene is KLF11.

UniProtKB/Swiss-Prot Summary for KLF10 Gene

  • Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.

Gene Wiki entry for KLF10 Gene

Additional gene information for KLF10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF10 Gene

Genomics for KLF10 Gene

GeneHancer (GH) Regulatory Elements for KLF10 Gene

Promoters and enhancers for KLF10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLF10

Top Transcription factor binding sites by QIAGEN in the KLF10 gene promoter:
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • Egr-4
  • Lmo2

Genomic Locations for KLF10 Gene

Genomic Locations for KLF10 Gene
chr8:102,648,777-102,655,902
(GRCh38/hg38)
Size:
7,126 bases
Orientation:
Minus strand
chr8:103,661,005-103,668,130
(GRCh37/hg19)
Size:
7,126 bases
Orientation:
Minus strand

Genomic View for KLF10 Gene

Genes around KLF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF10 Gene

Proteins for KLF10 Gene

  • Protein details for KLF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13118-KLF10_HUMAN
    Recommended name:
    Krueppel-like factor 10
    Protein Accession:
    Q13118
    Secondary Accessions:
    • A8MVH0
    • B2R794
    • L0R4P6
    • L0R679
    • O75411
    • Q503B2

    Protein attributes for KLF10 Gene

    Size:
    480 amino acids
    Molecular mass:
    52555 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLF10 Gene

    Alternative splice isoforms for KLF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF10 Gene

Post-translational modifications for KLF10 Gene

  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys223
  • Modification sites at PhosphoSitePlus

Other Protein References for KLF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF10 Gene

Domains & Families for KLF10 Gene

Gene Families for KLF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF10 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF10 Gene

GenScript: Design optimal peptide antigens:
  • Transforming growth factor-beta-inducible early growth response protein 1 (KLF10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13118

UniProtKB/Swiss-Prot:

KLF10_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF10: view

Function for KLF10 Gene

Molecular function for KLF10 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
UniProtKB/Swiss-Prot Induction:
By TGFB1 and BMP2.

Phenotypes From GWAS Catalog for KLF10 Gene

Gene Ontology (GO) - Molecular Function for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 15087465
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 15087465
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KLF10: view
genes like me logo Genes that share phenotypes with KLF10: view

Animal Models for KLF10 Gene

MGI Knock Outs for KLF10:

Animal Model Products

miRNA for KLF10 Gene

miRTarBase miRNAs that target KLF10
Targeted motifs for KLF10 Gene
HOMER Transcription Factor Regulatory Elements motif KLF10
  • Consensus sequence: GGGGGTGTGTCC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

  • Addgene plasmids for KLF10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF10 Gene

Localization for KLF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF10 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus TAS,ISS --
genes like me logo Genes that share ontologies with KLF10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF10 Gene

Pathways & Interactions for KLF10 Gene

PathCards logo

SuperPathways for KLF10 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with KLF10: view

Pathways by source for KLF10 Gene

2 BioSystems pathways for KLF10 Gene
1 GeneGo (Thomson Reuters) pathway for KLF10 Gene
  • Development_TGF-beta receptor signaling
54 Qiagen pathways for KLF10 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for KLF10 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 9748269
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007267 cell-cell signaling TAS 8532536
GO:0007623 circadian rhythm IEA --
genes like me logo Genes that share ontologies with KLF10: view

Drugs & Compounds for KLF10 Gene

(3) Drugs for KLF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF10: view

Transcripts for KLF10 Gene

mRNA/cDNA for KLF10 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for KLF10

Alternative Splicing Database (ASD) splice patterns (SP) for KLF10 Gene

No ASD Table

Relevant External Links for KLF10 Gene

GeneLoc Exon Structure for
KLF10

Expression for KLF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF10 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for KLF10 Gene

This gene is overexpressed in Tlymphocyte (40.0) and Peripheral blood mononuclear cells (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF10 Gene



Protein tissue co-expression partners for KLF10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLF10

SOURCE GeneReport for Unigene cluster for KLF10 Gene:

Hs.435001

Evidence on tissue expression from TISSUES for KLF10 Gene

  • Nervous system(4.6)
  • Eye(4.1)
  • Muscle(3.3)
  • Liver(2.5)
  • Lung(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with KLF10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF10 Gene

Orthologs for KLF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF10 31 30
  • 99.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TIEG1 31
  • 92 (a)
OneToOne
KLF10 30
  • 89.7 (n)
dog
(Canis familiaris)
Mammalia KLF10 31 30
  • 91.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Klf10 17 31 30
  • 84.27 (n)
rat
(Rattus norvegicus)
Mammalia Klf10 30
  • 83.58 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF10 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF10 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF10 31 30
  • 67.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF10 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf10 30
  • 59.14 (n)
zebrafish
(Danio rerio)
Actinopterygii FP017249.1 31
  • 59 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 31
  • 23 (a)
OneToMany
Species where no ortholog for KLF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF10 Gene

ENSEMBL:
Gene Tree for KLF10 (if available)
TreeFam:
Gene Tree for KLF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF10: view image

Paralogs for KLF10 Gene

(3) SIMAP similar genes for KLF10 Gene using alignment to 1 proteins:

  • KLF10_HUMAN
genes like me logo Genes that share paralogs with KLF10: view

Variants for KLF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KLF10 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs4734653 - p.Ser249Phe

Additional dbSNP identifiers (rs#s) for KLF10 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLF10 Gene

Variant ID Type Subtype PubMed ID
esv33118 CNV loss 17666407
nsv1075158 CNV deletion 25765185
nsv1126857 CNV deletion 24896259

Variation tolerance for KLF10 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF10 Gene

Human Gene Mutation Database (HGMD)
KLF10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF10 Gene

Disorders for KLF10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KLF10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemoglobinopathy
  • hemoglobinopathies
pancreatic cancer
  • pancreatic carcinoma
pancreatic adenocarcinoma
  • adenocarcinoma of the pancreas
brain cancer
  • adult brain tumor
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
- elite association - COSMIC cancer census association via MalaCards
Search KLF10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLF10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF10 Gene

Publications for KLF10 Gene

  1. TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters. (PMID: 9721211) Fautsch MP … Wieben ED (Genomics 1998) 2 3 4 23 54
  2. Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha. (PMID: 12804117) Chrisman HR … Tindall DJ (DNA and cell biology 2003) 3 4 23 54
  3. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. (PMID: 12072443) Johnsen SA … Spelsberg TC (The Journal of biological chemistry 2002) 3 4 23 54
  4. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. (PMID: 8584037) Blok LJ … Tindall DJ (Molecular endocrinology (Baltimore, Md.) 1995) 2 3 4 54
  5. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. (PMID: 8532536) Subramaniam M … Spelsberg TC (Nucleic acids research 1995) 3 4 23 54

Products for KLF10 Gene