This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009] See more...

Aliases for KLF1 Gene

Aliases for KLF1 Gene

  • Kruppel Like Factor 1 2 3 5
  • Erythroid Krueppel-Like Transcription Factor 3 4
  • Erythroid Kruppel-Like Factor 2 3
  • Krueppel-Like Factor 1 3 4
  • EKLF 3 4
  • Truncated Erythroid Kruppel-Like Factor EKLF/KLF1 3
  • Erythroid-Specific Transcription Factor EKLF 3
  • Kruppel-Like Factor 1 (Erythroid) 2
  • Truncated Kruppel-Like Factor 1 3
  • EKLF/KLF1 3

External Ids for KLF1 Gene

Previous GeneCards Identifiers for KLF1 Gene

  • GC19M013127
  • GC19M013218
  • GC19M012840
  • GC19M012856
  • GC19M012995
  • GC19M012567

Summaries for KLF1 Gene

Entrez Gene Summary for KLF1 Gene

  • This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]

GeneCards Summary for KLF1 Gene

KLF1 (Kruppel Like Factor 1) is a Protein Coding gene. Diseases associated with KLF1 include Anemia, Congenital Dyserythropoietic, Type Iv and Fetal Hemoglobin Quantitative Trait Locus 6. Among its related pathways are Hematopoietic Stem Cell Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter sequence-specific DNA binding. An important paralog of this gene is KLF4.

UniProtKB/Swiss-Prot Summary for KLF1 Gene

  • Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

Additional gene information for KLF1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLF1 Gene

Genomics for KLF1 Gene

GeneHancer (GH) Regulatory Elements for KLF1 Gene

Promoters and enhancers for KLF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012890 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 -4.1 -4091 2.2 ZNF785 SIN3A ZBTB40 SP1 SREBF1 SMARCE1 POLR2A ATF1 FOS CREB1 GCDH KLF1 ZNF700 CCDC130 ZNF44 ZNF136 ZNF564 ZNF799 TRIR WDR83OS
GH19J012887 Promoter/Enhancer 1 EPDnew dbSUPER 750.6 0.0 -18 0.1 L3MBTL2 GTF2F1 ZFX ATF1 MGA ZBTB11 MTA3 POLR2A ZBTB2 HDAC2 KLF1 GCDH RF00017-2824
GH19J013076 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.9 -191.2 -191170 5.1 L3MBTL2 ZNF148 ZFX CBFA2T2 EGR1 GMEB1 DPF2 GLIS2 ZIC2 ZBTB8A LYL1 ENSG00000242615 ZNF625 ZNF136 CCDC130 ZNF709 KLF1 ZNF564 ZNF791 ZNF443
GH19J012880 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.1 +3.7 3702 7 GTF3C2 SP1 ZBTB40 CTCF FOXA1 ZBTB6 SMARCE1 POLR2A RUNX1 CC2D1A DNASE2 ZNF791 ZNF700 CCDC130 ZNF44 MAN2B1 WDR83OS ZNF564 ENSG00000267519 MRI1
GH19J012889 Enhancer 0.3 CraniofacialAtlas 0.6 -2.8 -2784 0.4 ZC3H8 GCDH KLF1 RF00017-2824
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KLF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLF1 gene promoter:
  • AML1a

Genomic Locations for KLF1 Gene

Genomic Locations for KLF1 Gene
chr19:12,884,422-12,887,203
(GRCh38/hg38)
Size:
2,782 bases
Orientation:
Minus strand
chr19:12,995,236-12,998,017
(GRCh37/hg19)
Size:
2,782 bases
Orientation:
Minus strand

Genomic View for KLF1 Gene

Genes around KLF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF1 Gene

Proteins for KLF1 Gene

  • Protein details for KLF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13351-KLF1_HUMAN
    Recommended name:
    Krueppel-like factor 1
    Protein Accession:
    Q13351
    Secondary Accessions:
    • Q6PIJ5
    • Q92899

    Protein attributes for KLF1 Gene

    Size:
    362 amino acids
    Molecular mass:
    38221 Da
    Quaternary structure:
    • Interacts with PCAF; the interaction does not acetylate EKLF and inhibits its transactivation activity (By similarity). Interacts with CREBBP/CBP and EP300; the interactions enhance the transactivation activity. Interacts with TFB1.

    Three dimensional structures from OCA and Proteopedia for KLF1 Gene

neXtProt entry for KLF1 Gene

Post-translational modifications for KLF1 Gene

  • Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity (By similarity).
  • Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex (By similarity).
  • Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for KLF1

No data available for DME Specific Peptides for KLF1 Gene

Domains & Families for KLF1 Gene

Gene Families for KLF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF1 Gene

Suggested Antigen Peptide Sequences for KLF1 Gene

GenScript: Design optimal peptide antigens:
  • Erythroid Kruppel-like factor 1 variant (B7TQ30_HUMAN)
  • Erythroid Kruppel-like factor 1 variant (B7TQ31_HUMAN)
  • Erythroid Kruppel-like factor 1 variant (B9UZC3_HUMAN)
  • Erythroid Kruppel-like factor 1 variant (B9UZC4_HUMAN)
  • Erythroid Kruppel-like factor 1 variant (B9UZC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13351

UniProtKB/Swiss-Prot:

KLF1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF1: view

Function for KLF1 Gene

Molecular function for KLF1 Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
GENATLAS Biochemistry:
Kruppel-like factor 1(erythroid),zinc finger protein,red cell-specific transcription factor,binding to the CACCC site of the promoter,activating the beta globin synthesis in fetal liver and adult bone marrow

Phenotypes From GWAS Catalog for KLF1 Gene

Gene Ontology (GO) - Molecular Function for KLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0000987 proximal promoter sequence-specific DNA binding IBA,IDA 21539536
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KLF1: view
genes like me logo Genes that share phenotypes with KLF1: view

Human Phenotype Ontology for KLF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KLF1 Gene

MGI Knock Outs for KLF1:

Animal Model Products

CRISPR Products

miRNA for KLF1 Gene

miRTarBase miRNAs that target KLF1
Targeted motifs for KLF1 Gene
HOMER Transcription Factor Regulatory Elements motif KLF1
  • Consensus sequence: NTGGGTGTGGCC Submotif: canonical Cell Type: Erythrocyte GEO ID: GSE20478

Clone Products

  • Addgene plasmids for KLF1

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for KLF1 Gene

Localization for KLF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF1 Gene

Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF1 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 21539536
GO:0005634 nucleus IBA,IDA 21055716
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with KLF1: view

Pathways & Interactions for KLF1 Gene

PathCards logo

SuperPathways for KLF1 Gene

genes like me logo Genes that share pathways with KLF1: view

Pathways by source for KLF1 Gene

1 BioSystems pathway for KLF1 Gene

SIGNOR curated interactions for KLF1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IMP 25585695
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0030218 erythrocyte differentiation IBA,IMP 21055716
GO:0045893 positive regulation of transcription, DNA-templated IDA 15084587
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with KLF1: view

Drugs & Compounds for KLF1 Gene

(3) Drugs for KLF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF1: view

Transcripts for KLF1 Gene

mRNA/cDNA for KLF1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KLF1

Alternative Splicing Database (ASD) splice patterns (SP) for KLF1 Gene

No ASD Table

Relevant External Links for KLF1 Gene

GeneLoc Exon Structure for
KLF1
ECgene alternative splicing isoforms for
KLF1

Expression for KLF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF1 Gene

This gene is overexpressed in Whole Blood (x45.9).

Protein differential expression in normal tissues from HIPED for KLF1 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLF1 Gene



Protein tissue co-expression partners for KLF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLF1 Gene:

KLF1

SOURCE GeneReport for Unigene cluster for KLF1 Gene:

Hs.37860

mRNA Expression by UniProt/SwissProt for KLF1 Gene:

Q13351-KLF1_HUMAN
Tissue specificity: Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.

Evidence on tissue expression from TISSUES for KLF1 Gene

  • Lung(4.1)
  • Blood(3.4)
  • Bone marrow(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
Regions:
Head and neck:
  • brain
  • ear
  • head
  • mouth
Thorax:
  • heart
  • lung
  • thymus
Abdomen:
  • kidney
  • liver
  • spleen
Pelvis:
  • placenta
  • uterus
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with KLF1: view

Orthologs for KLF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF1 33 32
  • 99.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KLF1 33 32
  • 85.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KLF1 33 32
  • 84.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Klf1 17 33 32
  • 74.86 (n)
rat
(Rattus norvegicus)
Mammalia Klf1 32
  • 74.01 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF1 33
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia KLF1 33
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii klfd 33
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9895 34
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 34
  • 81 (a)
F53F8.1 34
  • 68 (a)
mua-1 34
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NRG2 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 23 (a)
OneToMany
Species where no ortholog for KLF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLF1 Gene

ENSEMBL:
Gene Tree for KLF1 (if available)
TreeFam:
Gene Tree for KLF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KLF1: view image

Paralogs for KLF1 Gene

(266) SIMAP similar genes for KLF1 Gene using alignment to 9 proteins:

  • KLF1_HUMAN
  • B7TQ30_HUMAN
  • B7TQ31_HUMAN
  • B9UZC3_HUMAN
  • B9UZC4_HUMAN
  • B9UZC5_HUMAN
  • B9UZC6_HUMAN
  • B9UZC7_HUMAN
  • K7VKE0_HUMAN
genes like me logo Genes that share paralogs with KLF1: view

Variants for KLF1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KLF1 Gene

KLF1_HUMAN-Q13351
Genetic variations in KLF1 underlie the fetal hemoglobin quantitative trait locus 6 (HBFQTL6) [MIM:613566]. Classic hereditary persistence of fetal hemoglobin (HPFH) is characterized by a substantial elevation of fetal hemoglobin (HbF) in adult red blood cells. There are no other phenotypic or hematologic manifestations. In healthy adults, fetal hemoglobin (HbF) is present at residual levels (less than 0.06% of total hemoglobin) with over 20-fold variation. Ten to fifteen percent of adults fall within the upper tail of the distribution.
KLF1_HUMAN-Q13351
Genetic variations in KLF1 underlie the blood group-Lutheran inhibitor (In(Lu)) phenotype [MIM:111150]; also known as dominant Lu (a-b-) phenotype. In(Lu) is characterized phenotypically by the apparent absence of the Lu antigen (BCAM) on red blood cells during serologic tests: Lu(a-b-).

Sequence variations from dbSNP and Humsavar for KLF1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs112631212 likely-benign, Congenital dyserythropoietic anemia 12,886,115(-) T/G coding_sequence_variant, initiator_codon_variant, missense_variant
rs117351327 benign, Congenital dyserythropoietic anemia 12,885,905(-) G/A coding_sequence_variant, missense_variant
rs137852687 pathogenic, BLOOD GROUP--LUTHERAN INHIBITOR 12,885,356(-) T/A/C coding_sequence_variant, missense_variant, stop_gained
rs137852688 pathogenic, likely-pathogenic, BLOOD GROUP--LUTHERAN INHIBITOR, not provided, -, - 12,885,335(-) G/A/C coding_sequence_variant, missense_variant
rs137908457 likely-benign, Congenital dyserythropoietic anemia 12,884,700(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for KLF1 Gene

Variant ID Type Subtype PubMed ID
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for KLF1 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF1 Gene

Human Gene Mutation Database (HGMD)
KLF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF1

SNP Genotyping and Copy Number Assay Products

Disorders for KLF1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for KLF1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search KLF1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KLF1_HUMAN
  • Anemia, congenital dyserythropoietic, 4 (CDAN4) [MIM:613673]: A blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin. {ECO:0000269 PubMed:21055716, ECO:0000269 PubMed:25585695}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for KLF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLF1: view

No data available for Genatlas for KLF1 Gene

Publications for KLF1 Gene

  1. The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13. (PMID: 9119377) van Ree JH … Cunningham JM (Genomics 1997) 2 3 4 23 56
  2. Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF). (PMID: 8924208) Bieker JJ (DNA and cell biology 1996) 2 3 4 23 56
  3. Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype. (PMID: 18487511) Singleton BK … Anstee DJ (Blood 2008) 3 4 23 56
  4. A new Krüppel-like factor 1 mutation (c.947G > A or p.C316Y) in humans causes β-thalassemia minor. (PMID: 25690802) Nitta T … Hattori Y (Hemoglobin 2015) 3 4 56
  5. Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin. (PMID: 25585695) Huang J … Xu X (European journal of human genetics : EJHG 2015) 3 4 56

Products for KLF1 Gene

Sources for KLF1 Gene