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KLC4 Gene(Protein Coding)

Kinesin Light Chain 4

GCID:
GC06P043040
GIFtS:
46
Genes Participants
UDN Logo

Aliases for KLC4 Gene

Aliases for KLC4 Gene

  • Kinesin Light Chain 4 2 3 5
  • Kinesin-Like Protein 8 3 4
  • KNSL8 3 4
  • Kinesin-Like 8 2
  • BA387M24.3 3
  • KLC 4 4

External Ids for KLC4 Gene

Previous HGNC Symbols for KLC4 Gene

  • KNSL8

Previous GeneCards Identifiers for KLC4 Gene

  • GC06P043136
  • GC06P043008
  • GC06P042744

Summaries for KLC4 Gene

GeneCards Summary for KLC4 Gene

KLC4 (Kinesin Light Chain 4) is a Protein Coding gene. Diseases associated with KLC4 include Hereditary Spastic Paraplegia. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include microtubule motor activity. An important paralog of this gene is KLC2.

UniProtKB/Swiss-Prot for KLC4 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Wiki entry for KLC4 Gene

Additional gene information for KLC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC4 Gene

Genomics for KLC4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for KLC4 Gene

Promoters and enhancers for KLC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06I043058 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.4 +19.5 19458 3.7 HDGF PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 MRPL2 KLC4 RRP36 POLH GTPBP2 DNPH1 ENSG00000272223 ENSG00000272170
GH06I043266 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +232.7 232675 13.1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 ZNF318 POLH POLR1C GTPBP2 ABCC10 RPS2P29 CUL7 XPO5 UBR2 KLC4
GH06I042928 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 -110.0 -109988 5.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 CNPY3 GC06M042930 PIR33684 PEX6 ZNF318 POLH GTPBP2 XPO5 RRP36 CUL7
GH06I043011 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 -26.0 -25954 7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 MEA1 KLHDC3 CUL7 KLC4 RN7SL403P PTK7 RPL7L1 DNPH1 PEX6 GC06P043011
GH06I043180 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +141.4 141387 3.2 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YBX1 POLR2B CUL9 CUL7 ZNF318 POLH GTPBP2 RPS2P29 DNPH1 ABCC10 BICRAL XPO5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLC4 gene promoter:

Genomic Locations for KLC4 Gene

Genomic Locations for KLC4 Gene
chr6:43,040,777-43,075,099
(GRCh38/hg38)
Size:
34,323 bases
Orientation:
Plus strand
chr6:43,008,515-43,042,837
(GRCh37/hg19)

Genomic View for KLC4 Gene

Genes around KLC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLC4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KLC4 Gene

Proteins for KLC4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KLC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSK0-KLC4_HUMAN
    Recommended name:
    Kinesin light chain 4
    Protein Accession:
    Q9NSK0
    Secondary Accessions:
    • B3KNY4
    • B3KPI3
    • B3KSQ3
    • B4DME9
    • Q66K28
    • Q96EG6

    Protein attributes for KLC4 Gene

    Size:
    619 amino acids
    Molecular mass:
    68640 Da
    Quaternary structure:
    • Oligomeric complex composed of two heavy chains and two light chains.
    SequenceCaution:
    • Sequence=BAC86788.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLC4 Gene

Protein Expression for KLC4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KLC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLC4 Gene

Domains & Families for KLC4 Gene

Gene Families for KLC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLC4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KLC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSK0

UniProtKB/Swiss-Prot:

KLC4_HUMAN :
  • Belongs to the kinesin light chain family.
Family:
  • Belongs to the kinesin light chain family.
genes like me logo Genes that share domains with KLC4: view

Function for KLC4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for KLC4 Gene

UniProtKB/Swiss-Prot Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Phenotypes From GWAS Catalog for KLC4 Gene

Gene Ontology (GO) - Molecular Function for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLC4: view

Phenotypes for KLC4 Gene

GenomeRNAi human phenotypes for KLC4:
genes like me logo Genes that share phenotypes with KLC4: view

Animal Model Products

miRNA for KLC4 Gene

miRTarBase miRNAs that target KLC4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLC4 Gene

Localization for KLC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLC4 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
mitochondrion 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KLC4: view

Pathways & Interactions for KLC4 Gene

genes like me logo Genes that share pathways with KLC4: view

Gene Ontology (GO) - Biological Process for KLC4 Gene

None

No data available for SIGNOR curated interactions for KLC4 Gene

Drugs & Compounds for KLC4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for KLC4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KLC4 Gene

(8) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(186) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLC4 Gene

Kinesin light chain 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLC4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - - - - -
SP14:

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KLC4 Gene

GeneLoc Exon Structure for
KLC4
ECgene alternative splicing isoforms for
KLC4

Expression for KLC4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLC4 Gene

mRNA expression in normal human tissues for KLC4 Gene
mRNA expression by GTEx for KLC4 GenemRNA expression by BioGPS for KLC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLC4 Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for KLC4 Gene

This gene is overexpressed in Heart (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLC4 Gene



Protein tissue co-expression partners for KLC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLC4 Gene:

KLC4

SOURCE GeneReport for Unigene cluster for KLC4 Gene:

Hs.655123

Evidence on tissue expression from TISSUES for KLC4 Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Adrenal gland(4.4)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with KLC4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLC4 Gene

Orthologs for KLC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KLC4 33 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
 Mammalia KLC4 34
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia KLC4 33 34
  • 90.69 (n)
cow
(Bos Taurus)
 Mammalia KLC4 33 34
  • 89.02 (n)
rat
(Rattus norvegicus)
 Mammalia Klc4 33
  • 87.94 (n)
mouse
(Mus musculus)
 Mammalia Klc4 33 16 34
  • 87.83 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia KLC4 34
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KLC4 33 34
  • 74.85 (n)
lizard
(Anolis carolinensis)
 Reptilia KLC4 34
  • 75 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii klc1b 33
  • 71 (n)
klc4 34 34
  • 69 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Klc 34
  • 68 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea klc-2 34
  • 58 (a)
 ManyToMany
klc-1 34
  • 42 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 63 (a)
 OneToMany
Species where no ortholog for KLC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLC4 Gene

ENSEMBL:
Gene Tree for KLC4 (if available)
TreeFam:
Gene Tree for KLC4 (if available)

Paralogs for KLC4 Gene

Paralogs for KLC4 Gene

(5) SIMAP similar genes for KLC4 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with KLC4: view

Variants for KLC4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for KLC4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000433413 -- 43,072,965(+) G/A genic_downstream_transcript_variant, splice_donor_variant
rs1000539582 -- 43,067,405(+) G/A/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000810369 -- 43,060,798(+) G/A intron_variant
rs1001398014 -- 43,068,300(+) C/T genic_downstream_transcript_variant, intron_variant
rs1001765872 -- 43,068,512(+) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KLC4 Gene

Variant ID Type Subtype PubMed ID
dgv10640n54 CNV loss 21841781
esv2446917 CNV deletion 19546169
esv2731992 CNV deletion 23290073
esv275497 CNV gain+loss 21479260
esv3567716 CNV deletion 23714750
nsv1017398 CNV gain 25217958
nsv1142639 CNV deletion 24896259
nsv437509 CNV loss 16327808
nsv462927 CNV loss 19166990
nsv462930 CNV loss 19166990
nsv602992 CNV loss 21841781
nsv950169 CNV deletion 24416366

Variation tolerance for KLC4 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLC4 Gene

Human Gene Mutation Database (HGMD)
KLC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLC4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC4 Gene

Disorders for KLC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hereditary spastic paraplegia
  • spastic paraplegia 3, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search KLC4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KLC4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KLC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLC4 Gene

Publications for KLC4 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for KLC4 Gene

Sources for KLC4 Gene

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