External Ids for KLC2 Gene
Previous GeneCards Identifiers for KLC2 Gene
The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016]
GeneCards Summary for KLC2 Gene
KLC2 (Kinesin Light Chain 2) is a Protein Coding gene. Diseases associated with KLC2 include Spastic Paraplegia, Optic Atrophy, And Neuropathy. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include microtubule motor activity and kinesin binding. An important paralog of this gene is KLC4.
UniProtKB/Swiss-Prot Summary for KLC2 Gene
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).