External Ids for KLC2 Gene
Previous GeneCards Identifiers for KLC2 Gene
The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016]
GeneCards Summary for KLC2 Gene
KLC2 (Kinesin Light Chain 2) is a Protein Coding gene. Diseases associated with KLC2 include Spastic Paraplegia, Optic Atrophy, And Neuropathy and Paraplegia. Among its related pathways are Signaling by GPCR and RHO GTPases activate KTN1. Gene Ontology (GO) annotations related to this gene include microtubule motor activity and kinesin binding. An important paralog of this gene is KLC4.
UniProtKB/Swiss-Prot Summary for KLC2 Gene
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).