Aliases for KIRREL2 Gene
External Ids for KIRREL2 Gene
Previous GeneCards Identifiers for KIRREL2 Gene
This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]
GeneCards Summary for KIRREL2 Gene
KIRREL2 (Kirre Like Nephrin Family Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with KIRREL2 include Hemophagocytic Lymphohistiocytosis, Familial, 3 and Familial Nephrotic Syndrome. Among its related pathways are Cell junction organization and Primary Focal Segmental Glomerulosclerosis FSGS. An important paralog of this gene is KIRREL1.
UniProtKB/Swiss-Prot Summary for KIRREL2 Gene
May regulate basal insulin secretion.