Aliases for KIR3DX1 Gene

Aliases for KIR3DX1 Gene

  • Killer Cell Immunoglobulin Like Receptor, Three Ig Domains X1 (Pseudogene) 2 3 5
  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, X1 2 3
  • Leukocyte Receptor Cluster (LRC) Member 12 2 3
  • KIR3DL0 3 4
  • LENG12 3 4
  • Putative Killer Cell Immunoglobulin-Like Receptor-Like Protein KIR3DX1 4
  • Killer Cell Immunoglobulin Like Receptor, Three Ig Domains X1 2
  • Immunoglobulin-Like Receptor KIR3DL0 3
  • Leukocyte Receptor Cluster Member 12 4

External Ids for KIR3DX1 Gene

Previous HGNC Symbols for KIR3DX1 Gene

  • LENG12

Previous GeneCards Identifiers for KIR3DX1 Gene

  • GC19P059740
  • GC19P055044
  • GC19P051367
  • GC19P054534

Summaries for KIR3DX1 Gene

GeneCards Summary for KIR3DX1 Gene

KIR3DX1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains X1 (Pseudogene)) is a Pseudogene.

Additional gene information for KIR3DX1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIR3DX1 Gene

Genomics for KIR3DX1 Gene

GeneHancer (GH) Regulatory Elements for KIR3DX1 Gene

Promoters and enhancers for KIR3DX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054532 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 758.3 +0.2 189 0.8 SP1 ETV6 IKZF2 EED RUNX3 EBF1 KIR3DX1 lnc-CDC42EP5-3
GH19J054661 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 11.3 +129.9 129889 3.6 SP1 ETV6 POLR2A CREM IKZF1 IKZF2 EED DPF2 BCL11A RUNX3 LILRB4 FCAR LAIR1 KIR3DX1 LILRB2 KIR2DL3 LILRB1 LILRA5 LILRB3 LILRA1
GH19J054615 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 8.9 +85.4 85429 4.6 ZNF24 SP1 ETV6 RELA NKRF POLR2A MAFK MLLT1 ZNF687 CREM LILRB1 LILRA2 KIR3DX1 LILRP2 LILRB2 piR-30791-044
GH19J054629 Promoter/Enhancer 0.8 EPDnew Ensembl ENCODE 11.7 +98.1 98129 1.6 LILRB1 KIR3DX1 LILRB2 piR-30791-044 NONHSAG026538.2
GH19J054652 Enhancer 0.8 Ensembl 11.5 +122.4 122408 4.6 CTCF MIXL1 RELA RAD21 DACH1 NKRF MLLT1 SMARCA4 TRIM24 KLF14 RPS9 ZNF581 RPL28 ENSG00000235681 CDC42EP5 CNOT3 KIR3DX1 LENG8 LILRB2 LENG8-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIR3DX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIR3DX1 gene promoter:
  • ARP-1
  • GR
  • GR-alpha
  • NRSF form 1
  • NRSF form 2
  • RORalpha1

Genomic Locations for KIR3DX1 Gene

Genomic Locations for KIR3DX1 Gene
chr19:54,532,692-54,545,771
(GRCh38/hg38)
Size:
13,080 bases
Orientation:
Plus strand
chr19:55,043,909-55,057,053
(GRCh37/hg19)
Size:
13,145 bases
Orientation:
Plus strand

Genomic View for KIR3DX1 Gene

Genes around KIR3DX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIR3DX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIR3DX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIR3DX1 Gene

Proteins for KIR3DX1 Gene

  • Protein details for KIR3DX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7L2-KI3X1_HUMAN
    Recommended name:
    Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1
    Protein Accession:
    Q9H7L2
    Secondary Accessions:
    • B7WNL0
    • Q8N0S4

    Protein attributes for KIR3DX1 Gene

    Size:
    352 amino acids
    Molecular mass:
    38777 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15757.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites and probable target of nonsense-mediated mRNA decay.; Evidence={ECO:0000305};

neXtProt entry for KIR3DX1 Gene

Post-translational modifications for KIR3DX1 Gene

  • Glycosylation at Asn78
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIR3DX1 Gene

Domains & Families for KIR3DX1 Gene

Gene Families for KIR3DX1 Gene

Protein Domains for KIR3DX1 Gene

Suggested Antigen Peptide Sequences for KIR3DX1 Gene

GenScript: Design optimal peptide antigens:
  • Leukocyte receptor cluster member 12 (KI3X1_HUMAN)
genes like me logo Genes that share domains with KIR3DX1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KIR3DX1 Gene

Function for KIR3DX1 Gene

Phenotypes From GWAS Catalog for KIR3DX1 Gene

genes like me logo Genes that share phenotypes with KIR3DX1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIR3DX1 Gene

Localization for KIR3DX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DX1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for KIR3DX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KIR3DX1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KIR3DX1 Gene

Pathways & Interactions for KIR3DX1 Gene

PathCards logo

SuperPathways for KIR3DX1 Gene

No Data Available

Interacting Proteins for KIR3DX1 Gene

Selected Interacting proteins: Q9H7L2-KI3X1_HUMAN for KIR3DX1 Gene via IID

Gene Ontology (GO) - Biological Process for KIR3DX1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIR3DX1 Gene

Drugs & Compounds for KIR3DX1 Gene

No Compound Related Data Available

Transcripts for KIR3DX1 Gene

mRNA/cDNA for KIR3DX1 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DX1 Gene

No ASD Table

Relevant External Links for KIR3DX1 Gene

GeneLoc Exon Structure for
KIR3DX1
ECgene alternative splicing isoforms for
KIR3DX1

Expression for KIR3DX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIR3DX1 Gene

mRNA differential expression in normal tissues according to GTEx for KIR3DX1 Gene

This gene is overexpressed in Whole Blood (x26.9).

NURSA nuclear receptor signaling pathways regulating expression of KIR3DX1 Gene:

KIR3DX1

SOURCE GeneReport for Unigene cluster for KIR3DX1 Gene:

Hs.288520

mRNA Expression by UniProt/SwissProt for KIR3DX1 Gene:

Q9H7L2-KI3X1_HUMAN
Tissue specificity: Expressed in NK-cells.

Evidence on tissue expression from TISSUES for KIR3DX1 Gene

  • Spleen(4.1)
genes like me logo Genes that share expression patterns with KIR3DX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIR3DX1 Gene

Orthologs for KIR3DX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIR3DX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIR3DX1 33
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 33
  • 43 (a)
OneToMany
-- 33
  • 43 (a)
OneToMany
KIR3DL1 33
  • 39 (a)
OneToMany
-- 33
  • 38 (a)
OneToMany
KIR2DS1 33
  • 37 (a)
OneToMany
-- 33
  • 37 (a)
OneToMany
-- 33
  • 36 (a)
OneToMany
-- 33
  • 36 (a)
OneToMany
-- 33
  • 34 (a)
OneToMany
-- 33
  • 33 (a)
OneToMany
-- 33
  • 32 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 30 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 25 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 15 (a)
ManyToMany
-- 33
  • 12 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 14 (a)
OneToMany
Species where no ortholog for KIR3DX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIR3DX1 Gene

ENSEMBL:
Gene Tree for KIR3DX1 (if available)
TreeFam:
Gene Tree for KIR3DX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIR3DX1: view image

Paralogs for KIR3DX1 Gene

No data available for Paralogs for KIR3DX1 Gene

Variants for KIR3DX1 Gene

Sequence variations from dbSNP and Humsavar for KIR3DX1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000066254 -- 54,533,164(+) G/C intron_variant
rs1000319 -- 54,535,145(+) C/G/T intron_variant
rs1000320 -- 54,535,161(+) T/C intron_variant
rs1000321 -- 54,535,268(+) G/T intron_variant
rs1000327581 -- 54,540,673(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIR3DX1 Gene

Variant ID Type Subtype PubMed ID
dgv3663n100 CNV gain 25217958
dgv435n27 CNV loss 19166990
dgv6563n54 CNV loss 21841781
esv1013807 CNV deletion 17803354
esv2118143 CNV deletion 18987734
esv2667609 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv3644811 CNV gain 21293372
nsv1065887 CNV loss 25217958
nsv1148744 OTHER inversion 26484159
nsv470158 CNV loss 18288195
nsv518262 CNV gain 19592680
nsv522872 CNV loss 19592680
nsv828638 CNV loss 20364138

Variation tolerance for KIR3DX1 Gene

Gene Damage Index Score: 3.19; 52.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIR3DX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIR3DX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIR3DX1 Gene

Disorders for KIR3DX1 Gene

Additional Disease Information for KIR3DX1

No disorders were found for KIR3DX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIR3DX1 Gene

Publications for KIR3DX1 Gene

  1. Identification of the ancestral killer immunoglobulin-like receptor gene in primates. (PMID: 16911775) Sambrook JG … Beck S (BMC genomics 2006) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P … Stubbs L (Science (New York, N.Y.) 2001) 2 3 56
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 56

Products for KIR3DX1 Gene

Sources for KIR3DX1 Gene