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Aliases for KIR3DP1 Gene

Aliases for KIR3DP1 Gene

  • Killer Cell Immunoglobulin Like Receptor, Three Ig Domains Pseudogene 1 2 3 5
  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Pseudogene 1 2 3
  • KIR2DS6 3 4
  • CD158c 3 4
  • KIR48 3 4
  • KIRX 3 4
  • Killer-Cell Ig-Like Receptor Pseudogene 3
  • CD158c Antigen 4
  • KIR3DS2P 3

External Ids for KIR3DP1 Gene

Previous GeneCards Identifiers for KIR3DP1 Gene

  • GC19P059992
  • GC19U900570
  • GC19P059976
  • GC19P059977
  • GC19P059978
  • GC19P059979
  • GC19P059993
  • GC19P059982
  • GC19P059994
  • GC19P055297
  • GC19P051620
  • GC19P054865
  • GC19P054896
  • GC19P054914
  • GC19P054932
  • GC19P054951
  • GC19P054972
  • GC19P054993

Summaries for KIR3DP1 Gene

Entrez Gene Summary for KIR3DP1 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. This gene is considered to be a pseudogene based on the absence of transcription and it lacks several functional domains compared to other killer cell immunoglobulin-like receptors. A rare haplotype, the result of a recombinantion event, has two copies of this gene, one of which may encode a secreted protein. (PMID: 15580659)[provided by RefSeq, Mar 2011]

GeneCards Summary for KIR3DP1 Gene

KIR3DP1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains Pseudogene 1) is a Pseudogene.

Additional gene information for KIR3DP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DP1 Gene

Genomics for KIR3DP1 Gene

GeneHancer (GH) Regulatory Elements for KIR3DP1 Gene

Promoters and enhancers for KIR3DP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I054792 Enhancer 0.4 Ensembl 0.4 +6.5 6546 1 IRF2 NR2F2 KIR2DL3 KIR3DL1 KIR3DL3 NLRP2 NLRP7 ENSG00000243494 KIR3DX1 EPS8L1 RDH13 KIR3DP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIR3DP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KIR3DP1 Gene

Genomic Locations for KIR3DP1 Gene
4,064 bases
Plus strand

Genomic View for KIR3DP1 Gene

Genes around KIR3DP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIR3DP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIR3DP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIR3DP1 Gene

  • Protein details for KIR3DP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative killer cell immunoglobulin-like receptor like protein KIR3DP1
    Protein Accession:

    Protein attributes for KIR3DP1 Gene

    328 amino acids
    Molecular mass:
    36055 Da
    Quaternary structure:
    No Data Available
    • PubMed:15580659, identified a chromosomal rearrangement producing a recombinant gene composed of the promoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This leads to the expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric protein KIR2DL5A/KIR3DP1.

neXtProt entry for KIR3DP1 Gene

Post-translational modifications for KIR3DP1 Gene

  • Glycosylation at isoforms=162
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIR3DP1 Gene

Domains & Families for KIR3DP1 Gene

Protein Domains for KIR3DP1 Gene

Suggested Antigen Peptide Sequences for KIR3DP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIR3DP1: view

No data available for UniProtKB/Swiss-Prot for KIR3DP1 Gene

Function for KIR3DP1 Gene

Phenotypes for KIR3DP1 Gene

GenomeRNAi human phenotypes for KIR3DP1:
genes like me logo Genes that share phenotypes with KIR3DP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR3DP1 Gene

Localization for KIR3DP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DP1 Gene


Gene Ontology (GO) - Cellular Components for KIR3DP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KIR3DP1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KIR3DP1 Gene

Pathways & Interactions for KIR3DP1 Gene

No data available for Pathways by source and SIGNOR curated interactions for KIR3DP1 Gene

Drugs & Compounds for KIR3DP1 Gene

No Compound Related Data Available

Transcripts for KIR3DP1 Gene

mRNA/cDNA for KIR3DP1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DP1 Gene

No ASD Table

Relevant External Links for KIR3DP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIR3DP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIR3DP1 Gene

mRNA expression in normal human tissues for KIR3DP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIR3DP1 Gene:


mRNA Expression by UniProt/SwissProt for KIR3DP1 Gene:

Tissue specificity: Expressed in peripheral blood cells.
genes like me logo Genes that share expression patterns with KIR3DP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIR3DP1 Gene

Orthologs for KIR3DP1 Gene

Evolution for KIR3DP1 Gene

Gene Tree for KIR3DP1 (if available)
Gene Tree for KIR3DP1 (if available)

No data available for Orthologs for KIR3DP1 Gene

Paralogs for KIR3DP1 Gene

No data available for Paralogs for KIR3DP1 Gene

Variants for KIR3DP1 Gene

Sequence variations from dbSNP and Humsavar for KIR3DP1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs17699088 -- p.Lys160Thr
rs597068 -- p.Glu258Asp

Additional Variant Information for KIR3DP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for KIR3DP1 Gene

Disorders for KIR3DP1 Gene

Additional Disease Information for KIR3DP1

Genetic Association Database
Human Genome Epidemiology Navigator

No disorders were found for KIR3DP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIR3DP1 Gene

Publications for KIR3DP1 Gene

  1. The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. (PMID: 15580659) Gómez-Lozano N … Vilches C (European journal of immunology 2005) 2 3 4 22 58
  2. Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PMID: 19000141) Velickovic M … Dunckley H (Tissue antigens 2009) 3 22 44 58
  3. Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease. (PMID: 19450876) Zhang Y … Qi J (Leukemia research 2010) 3 44 58
  4. Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection. (PMID: 19846535) Vidal-Castiñeira JR … López-Larrea C (Journal of virology 2010) 3 44 58
  5. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. (PMID: 19861144) Bonagura VR … Rajalingam R (Human immunology 2010) 3 44 58

Products for KIR3DP1 Gene

Sources for KIR3DP1 Gene

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