Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "f... See more...

Aliases for KIR3DP1 Gene

Aliases for KIR3DP1 Gene

  • Killer Cell Immunoglobulin Like Receptor, Three Ig Domains Pseudogene 1 2 3 5
  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Pseudogene 1 2 3
  • KIR3DS2P 2 3
  • KIR2DS6 2 3
  • KIR48 2 3
  • KIRX 2 3
  • Killer Cell Immunoglobulin-Like Receptor, Three Ig Domains Pseudogene 1 13
  • Killer-Cell Ig-Like Receptor Pseudogene 3
  • KIR3DP1 5
  • CD158c 3
  • CD158C 2

External Ids for KIR3DP1 Gene

Previous GeneCards Identifiers for KIR3DP1 Gene

  • GC19P059992
  • GC19U900570
  • GC19P059976
  • GC19P059977
  • GC19P059978
  • GC19P059979
  • GC19P059993
  • GC19P059982
  • GC19P059994
  • GC19P055297
  • GC19P051620
  • GC19P054865
  • GC19P054896
  • GC19P055098
  • GC19P055128
  • GC19P055152
  • GC19P055291
  • GC19P054914
  • GC19P054932
  • GC19P054951
  • GC19P054972
  • GC19P054993
  • GC19P055021
  • GC19P055048
  • GC19P055075
  • GC19P055440
  • GC19P055630

Summaries for KIR3DP1 Gene

Entrez Gene Summary for KIR3DP1 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. This gene is considered to be a pseudogene based on the absence of transcription and it lacks several functional domains compared to other killer cell immunoglobulin-like receptors. A rare haplotype, the result of a recombinantion event, has two copies of this gene, one of which may encode a secreted protein. (PMID: 15580659)[provided by RefSeq, Mar 2011]

GeneCards Summary for KIR3DP1 Gene

KIR3DP1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains Pseudogene 1) is a Pseudogene. Diseases associated with KIR3DP1 include Partial Duplication Of Chromosome 19 and Duane Retraction Syndrome.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIR3DP1 Gene

Genomics for KIR3DP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIR3DP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J054786 Enhancer 0.3 Ensembl 250.7 +1.6 1645 2.4 SPI1 ATF4 KIR3DP1 KIR2DL1 KIR2DL4 HSALNG0127572 LOC101928804 ENSG00000215765
GH19J054769 Promoter 0.3 EPDnew 0.4 -16.6 -16555 0.1 KIR2DL1 KIR3DP1 KIR2DL4 ENSG00000215765 LOC101928804
GH19J054777 Enhancer 0.2 Ensembl 0.4 -6.4 -6354 3.6 LILRB1 KIR3DP1 KIR2DL1 KIR2DL4 ENSG00000215765 LOC101928804
GH19J054772 Enhancer 0.2 Ensembl 0.4 -13.0 -12954 1.2 KIR2DL1 KIR3DP1 KIR2DL4 ENSG00000215765 LOC101928804
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIR3DP1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for KIR3DP1 Gene

Latest Assembly
chr19:54,786,355-54,790,418
(GRCh38/hg38)
Size:
4,064 bases
Orientation:
Plus strand

Previous Assembly
chr19:55,297,814-55,301,870
(GRCh37/hg19 by Entrez Gene)
Size:
4,057 bases
Orientation:
Plus strand

chr19:55,297,807-55,301,770
(GRCh37/hg19 by Ensembl)
Size:
3,964 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr19(ALT_REF_LOCI_1):692,021-696,077 (+)
  • chr19(ALT_REF_LOCI_10):112,330-116,382 (-)
  • chr19(ALT_REF_LOCI_11):78,421-82,477 (-)
  • chr19(ALT_REF_LOCI_13):78,990-83,046 (-)
  • chr19(ALT_REF_LOCI_14):67,790-71,842 (-)
  • chr19(ALT_REF_LOCI_15):118,007-122,063 (-)
  • chr19(ALT_REF_LOCI_17):78,681-82,737 (-)
  • chr19(ALT_REF_LOCI_19):78,697-82,753 (-)
  • chr19(ALT_REF_LOCI_2):404,220-408,276 (+)
  • chr19(ALT_REF_LOCI_20):68,583-72,639 (-)
  • chr19(ALT_REF_LOCI_21):78,681-82,737 (-)
  • chr19(ALT_REF_LOCI_23):65,274-69,330 (+)
  • chr19(ALT_REF_LOCI_24):87,940-91,996 (+)
  • chr19(ALT_REF_LOCI_25):78,660-82,716 (-)
  • chr19(ALT_REF_LOCI_26):73,200-77,256 (+)
  • chr19(ALT_REF_LOCI_27):129,368-133,420 (+)
  • chr19(ALT_REF_LOCI_28):62,276-66,332 (+)
  • chr19(ALT_REF_LOCI_30):60,538-64,594 (+)
  • chr19(ALT_REF_LOCI_32):78,173-82,229 (-)
  • chr19(ALT_REF_LOCI_33):79,022-83,078 (-)
  • chr19(ALT_REF_LOCI_34):78,485-82,541 (-)
  • chr19(ALT_REF_LOCI_7):690,696-694,752 (+)
  • chr19(ALT_REF_LOCI_8):497,310-503,730 (+)
  • chr19(ALT_REF_LOCI_9):768,928-772,984 (+)
  • chr19(PATCHES):87,782-91,834 (+)

Genomic View for KIR3DP1 Gene

Genes around KIR3DP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIR3DP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIR3DP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIR3DP1 Gene

  • Protein details for KIR3DP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0G2JN09-A0A0G2JN09_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor, three Ig domains pseudogene 1
    Protein Accession:
    A0A0G2JN09

    Protein attributes for KIR3DP1 Gene

    Size:
    328 amino acids
    Molecular mass:
    36037 Da
    Quaternary structure:
    No Data Available
  • Protein details for KIR3DP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0G2JN01-A0A0G2JN01_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor, three Ig domains pseudogene 1
    Protein Accession:
    A0A0G2JN01

    Protein attributes for KIR3DP1 Gene

    Size:
    328 amino acids
    Molecular mass:
    36023 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR3DP1 Gene

Post-translational modifications for KIR3DP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KIR3DP1 Gene

Domains & Families for KIR3DP1 Gene

Gene Families for KIR3DP1 Gene

Protein Domains for KIR3DP1 Gene

Suggested Antigen Peptide Sequences for KIR3DP1 Gene

GenScript: Design optimal peptide antigens:
  • Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 (KI3P1_HUMAN)
genes like me logo Genes that share domains with KIR3DP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KIR3DP1 Gene

Function for KIR3DP1 Gene

Phenotypes From GWAS Catalog for KIR3DP1 Gene

genes like me logo Genes that share phenotypes with KIR3DP1: view

Animal Models for research

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR3DP1 Gene

Localization for KIR3DP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for KIR3DP1 Gene

Pathways & Interactions for KIR3DP1 Gene

PathCards logo

SuperPathways for KIR3DP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIR3DP1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for KIR3DP1 Gene

Drugs & Compounds for KIR3DP1 Gene

No Compound Related Data Available

Transcripts for KIR3DP1 Gene

mRNA/cDNA for KIR3DP1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIR3DP1

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DP1 Gene

No ASD Table

Relevant External Links for KIR3DP1 Gene

GeneLoc Exon Structure for
KIR3DP1

Expression for KIR3DP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIR3DP1 Gene

mRNA expression in normal human tissues for KIR3DP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIR3DP1

genes like me logo Genes that share expression patterns with KIR3DP1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIR3DP1 Gene

Orthologs for KIR3DP1 Gene

Evolution for KIR3DP1 Gene

ENSEMBL:
Gene Tree for KIR3DP1 (if available)
TreeFam:
Gene Tree for KIR3DP1 (if available)
Alliance of Genome Resources:
Additional Orthologs for KIR3DP1

No data available for Orthologs for KIR3DP1 Gene

Paralogs for KIR3DP1 Gene

No data available for Paralogs for KIR3DP1 Gene

Variants for KIR3DP1 Gene

Additional Variant Information for KIR3DP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIR3DP1
Leiden Open Variation Database (LOVD)
KIR3DP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for KIR3DP1 Gene

Disorders for KIR3DP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIR3DP1 Gene - From: GCD

Disorder Aliases PubMed IDs
partial duplication of chromosome 19
  • partial trisomy of chromosome 19
duane retraction syndrome
  • duane's syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KIR3DP1

Human Genome Epidemiology Navigator
(HuGE)
genes like me logo Genes that share disorders with KIR3DP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIR3DP1 Gene

Publications for KIR3DP1 Gene

  1. Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PMID: 19000141) Velickovic M … Dunckley H (Tissue antigens 2009) 3 22 40
  2. The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. (PMID: 15580659) Gómez-Lozano N … Vilches C (European journal of immunology 2005) 2 3 22
  3. Immunogenetic characteristics of patients with autoimmune gastritis. (PMID: 20082482) Oksanen AM … Partanen JA (World journal of gastroenterology 2010) 3 40
  4. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PMID: 20878400) Wauquier N … Vieillard V (Immunogenetics 2010) 3 40
  5. Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease. (PMID: 19450876) Zhang Y … Qi J (Leukemia research 2010) 3 40

Products for KIR3DP1 Gene

Sources for KIR3DP1 Gene