Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "f... See more...

Aliases for KIR2DL5A Gene

Aliases for KIR2DL5A Gene

  • Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A 2 3
  • KIR2DL5 2 3 4
  • CD158F 2 3 4
  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A 2 3
  • Killer Cell Immunoglobulin-Like Receptor 2DL5A 3 4
  • KIR2DL5.1 2 3
  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5 3
  • Killer Cell Immunoglobulin-Like Receptor KIR2DL5A 3
  • CD158f1 Antigen 4
  • KIR2DL5.3 3
  • CD158F1 4

External Ids for KIR2DL5A Gene

Previous GeneCards Identifiers for KIR2DL5A Gene

  • GC19P9H0088
  • GC19P9I0086
  • GC19P9I0011
  • GC19P9I0013
  • GC19P9I0015
  • GC19P9I0017
  • GC19P9I0019
  • GC19P9Q0450
  • GC19U902088
  • GC19M8W0046
  • GC19Ms00060

Summaries for KIR2DL5A Gene

Entrez Gene Summary for KIR2DL5A Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DL5A Gene

KIR2DL5A (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Allograft rejection.

UniProtKB/Swiss-Prot Summary for KIR2DL5A Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Additional gene information for KIR2DL5A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIR2DL5A Gene

Genomics for KIR2DL5A Gene

Genomic Locations for KIR2DL5A Gene

Genomic Locations for KIR2DL5A Gene
chr19:46,835-56,299
(GRCh38/hg38)
Size:
9,465 bases
Orientation:
Minus strand

Genomic View for KIR2DL5A Gene

Genes around KIR2DL5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for KIR2DL5A Gene

No data available for GeneHancer (GH) Regulatory Elements for KIR2DL5A Gene

Proteins for KIR2DL5A Gene

  • Protein details for KIR2DL5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N109-KI2LA_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DL5A
    Protein Accession:
    Q8N109

    Protein attributes for KIR2DL5A Gene

    Size:
    375 amino acids
    Molecular mass:
    40678 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR2DL5A Gene

Post-translational modifications for KIR2DL5A Gene

  • Glycosylation at Asn139, Asn173, and Asn218
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR2DL5A Gene

REFSEQ proteins:

No data available for DME Specific Peptides for KIR2DL5A Gene

Domains & Families for KIR2DL5A Gene

Gene Families for KIR2DL5A Gene

Protein Domains for KIR2DL5A Gene

Suggested Antigen Peptide Sequences for KIR2DL5A Gene

GenScript: Design optimal peptide antigens:
  • KIR2DL5A (B0L652_HUMAN)
  • Killer cell immunoglobulin-like receptor 2DL5A (KI2LA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N109

UniProtKB/Swiss-Prot:

KI2LA_HUMAN :
  • Belongs to the immunoglobulin superfamily.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR2DL5A: view

Function for KIR2DL5A Gene

Molecular function for KIR2DL5A Gene

UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Phenotypes From GWAS Catalog for KIR2DL5A Gene

genes like me logo Genes that share phenotypes with KIR2DL5A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIR2DL5A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR2DL5A Gene

Localization for KIR2DL5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DL5A Gene

Cell membrane. Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DL5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIR2DL5A: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KIR2DL5A Gene

Pathways & Interactions for KIR2DL5A Gene

PathCards logo

SuperPathways for KIR2DL5A Gene

genes like me logo Genes that share pathways with KIR2DL5A: view

Pathways by source for KIR2DL5A Gene

1 GeneGo (Thomson Reuters) pathway for KIR2DL5A Gene
  • Immune response Role of DAP12 receptors in NK cells

Interacting Proteins for KIR2DL5A Gene

Selected Interacting proteins: Q8N109-KI2LA_HUMAN for KIR2DL5A Gene via IID

Gene Ontology (GO) - Biological Process for KIR2DL5A Gene

None

No data available for SIGNOR curated interactions for KIR2DL5A Gene

Drugs & Compounds for KIR2DL5A Gene

(1) Drugs for KIR2DL5A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KIR2DL5A: view

Transcripts for KIR2DL5A Gene

mRNA/cDNA for KIR2DL5A Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIR2DL5A

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DL5A Gene

No ASD Table

Relevant External Links for KIR2DL5A Gene

GeneLoc Exon Structure for
KIR2DL5A

Expression for KIR2DL5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIR2DL5A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIR2DL5A

SOURCE GeneReport for Unigene cluster for KIR2DL5A Gene:

Hs.740906
genes like me logo Genes that share expression patterns with KIR2DL5A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIR2DL5A Gene

Orthologs for KIR2DL5A Gene

No data available for Orthologs and Evolution for KIR2DL5A Gene

Paralogs for KIR2DL5A Gene

No data available for Paralogs for KIR2DL5A Gene

Variants for KIR2DL5A Gene

Additional dbSNP identifiers (rs#s) for KIR2DL5A Gene

Additional Variant Information for KIR2DL5A Gene

Human Gene Mutation Database (HGMD)
KIR2DL5A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIR2DL5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for KIR2DL5A Gene

Disorders for KIR2DL5A Gene

Additional Disease Information for KIR2DL5A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KIR2DL5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIR2DL5A Gene

Publications for KIR2DL5A Gene

  1. Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. (PMID: 12185535) Gómez-Lozano N … Vilches C (Immunogenetics 2002) 2 3 4 23
  2. Activating KIR genes are associated with ankylosing spondylitis in Asian populations. (PMID: 18638658) Díaz-Peña R … López-Larrea C (Human immunology 2008) 3 23 41
  3. Natural killer cell receptor and HLA-C gene polymorphisms among patients with hepatitis C: a comparison between sustained virological responders and non-responders. (PMID: 20456039) Carneiro VL … Lyra AC (Liver international : official journal of the International Association for the Study of the Liver 2010) 3 41
  4. [Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes]. (PMID: 20356536) Tan YY … Zhou ZG (Zhonghua yi xue za zhi 2010) 3 41
  5. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. (PMID: 19861144) Bonagura VR … Rajalingam R (Human immunology 2010) 3 41

Products for KIR2DL5A Gene

Sources for KIR2DL5A Gene