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Aliases for KIR2DL2 Gene

Aliases for KIR2DL2 Gene

  • Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 2 2 3
  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 2 2 3
  • P58 Natural Killer Cell Receptor Clone CL-43 3 4
  • Natural Killer-Associated Transcript 6 3 4
  • CD158 Antigen-Like Family Member B1 3 4
  • MHC Class I NK Cell Receptor 3 4
  • P58 NK Receptor CL-43 3 4
  • CD158B1 3 4
  • NKAT-6 3 4
  • NKAT6 3 4
  • Killer Cell Immunoglobulin-Like Receptor 2DL2 3
  • CD158b1 Antigen 4
  • CD158b 3
  • P58.2 3

External Ids for KIR2DL2 Gene

Previous GeneCards Identifiers for KIR2DL2 Gene

  • GC19P055403
  • GC19P9D0021
  • GC19P9F0022
  • GC00P9Q0021
  • GC19P9H0021
  • GC19P059935
  • GC19P9I0021
  • GC19U901039
  • GC19P9J0008
  • GC19P9I0006
  • GC19P9I0029
  • GC19Pk00737

Summaries for KIR2DL2 Gene

Entrez Gene Summary for KIR2DL2 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DL2 Gene

KIR2DL2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 2) is a Protein Coding gene. Diseases associated with KIR2DL2 include Trachoma. Among its related pathways are Innate Immune System and Allograft rejection.

UniProtKB/Swiss-Prot for KIR2DL2 Gene

  • Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.

Additional gene information for KIR2DL2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DL2 Gene

Genomics for KIR2DL2 Gene

Genomic Locations for KIR2DL2 Gene

Genomic Locations for KIR2DL2 Gene
14,544 bases
Minus strand

Genomic View for KIR2DL2 Gene

Genes around KIR2DL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements for KIR2DL2 Gene

Proteins for KIR2DL2 Gene

  • Protein details for KIR2DL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DL2
    Protein Accession:
    Secondary Accessions:
    • C6EVR8
    • Q14951

    Protein attributes for KIR2DL2 Gene

    348 amino acids
    Molecular mass:
    38472 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KIR2DL2 Gene

neXtProt entry for KIR2DL2 Gene

Post-translational modifications for KIR2DL2 Gene

  • Glycosylation at posLast=8484, isoforms=178, and isoforms=211

Other Protein References for KIR2DL2 Gene

No data available for DME Specific Peptides for KIR2DL2 Gene

Domains & Families for KIR2DL2 Gene

Protein Domains for KIR2DL2 Gene

Suggested Antigen Peptide Sequences for KIR2DL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR2DL2: view

Function for KIR2DL2 Gene

Molecular function for KIR2DL2 Gene

GENATLAS Biochemistry:
natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigens,2DL2,58kDa,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.
genes like me logo Genes that share phenotypes with KIR2DL2: view

Clone Products

  • R&D Systems cDNA Clones for KIR2DL2 (KIR2DL2/CD158b1)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR2DL2 Gene

Localization for KIR2DL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DL2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIR2DL2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KIR2DL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIR2DL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIR2DL2 Gene

Pathways & Interactions for KIR2DL2 Gene

genes like me logo Genes that share pathways with KIR2DL2: view

Gene Ontology (GO) - Biological Process for KIR2DL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KIR2DL2: view

No data available for SIGNOR curated interactions for KIR2DL2 Gene

Drugs & Compounds for KIR2DL2 Gene

(1) Drugs for KIR2DL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KIR2DL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KIR2DL2: view

Transcripts for KIR2DL2 Gene

mRNA/cDNA for KIR2DL2 Gene

Unigene Clusters for KIR2DL2 Gene

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for KIR2DL2 (KIR2DL2/CD158b1)

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DL2 Gene

No ASD Table

Relevant External Links for KIR2DL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIR2DL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIR2DL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIR2DL2 Gene:


SOURCE GeneReport for Unigene cluster for KIR2DL2 Gene:


Evidence on tissue expression from TISSUES for KIR2DL2 Gene

  • Blood(2.6)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with KIR2DL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIR2DL2 Gene

Orthologs for KIR2DL2 Gene

No data available for Orthologs and Evolution for KIR2DL2 Gene

Paralogs for KIR2DL2 Gene

No data available for Paralogs for KIR2DL2 Gene

Variants for KIR2DL2 Gene

Sequence variations from dbSNP and Humsavar for KIR2DL2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs3810343 -- p.Ala9Val
rs613240 -- p.Arg37Pro
rs673568 -- p.Phe66Tyr

Structural Variations from Database of Genomic Variants (DGV) for KIR2DL2 Gene

Variant ID Type Subtype PubMed ID
nsv978852 CNV duplication 23825009
nsv9761 CNV gain+loss 18304495
nsv956586 CNV deletion 24416366
nsv953619 CNV duplication 24416366
nsv953618 CNV duplication 24416366
nsv833879 CNV gain+loss 17160897
nsv580320 CNV loss 21841781
nsv580315 CNV loss 21841781
nsv580311 CNV loss 21841781
nsv580310 CNV gain 21841781
nsv580305 CNV loss 21841781
nsv580304 CNV gain 21841781
nsv580303 CNV loss 21841781
nsv580302 CNV gain 21841781
nsv580301 CNV loss 21841781
nsv580300 CNV gain+loss 21841781
nsv580293 CNV gain 21841781
nsv580290 CNV gain+loss 21841781
nsv580289 CNV loss 21841781
nsv580284 CNV gain 21841781
nsv580281 CNV loss 21841781
nsv580280 CNV loss 21841781
nsv580272 CNV loss 21841781
nsv580271 CNV loss 21841781
nsv580255 CNV gain 21841781
nsv580253 CNV loss 21841781
nsv580252 CNV gain 21841781
nsv580246 CNV gain 21841781
nsv580245 CNV loss 21841781
nsv517143 CNV gain+loss 19592680
nsv514902 CNV gain 21397061
nsv471706 CNV loss 15918152
nsv469656 CNV loss 16826518
nsv437834 CNV loss 16327808
nsv436250 CNV deletion 17901297
nsv428372 CNV gain+loss 18775914
nsv138103 CNV insertion 16902084
nsv1160665 CNV deletion 26073780
nsv1133455 CNV deletion 24896259
nsv1071948 CNV deletion 25765185
esv6207 CNV loss 19470904
esv3644817 CNV gain 21293372
esv3644816 CNV loss 21293372
esv32828 CNV loss 17666407
esv2758771 CNV gain+loss 17122850
esv2718928 CNV deletion 23290073
esv2718927 CNV deletion 23290073
esv2718925 CNV deletion 23290073
esv2718916 CNV deletion 23290073
esv2718915 CNV deletion 23290073
esv2718914 CNV deletion 23290073
esv2718872 CNV deletion 23290073
esv2668465 CNV deletion 23128226
esv2667609 CNV deletion 23128226
esv26630 CNV gain+loss 19812545
esv2661467 CNV deletion 23128226
esv2421952 CNV deletion 20811451
dgv76e203 CNV gain+loss 21179565
dgv672e214 CNV loss 21293372
dgv668e199 CNV deletion 23128226
dgv667e199 CNV deletion 23128226
dgv6579n54 CNV loss 21841781
dgv6578n54 CNV loss 21841781
dgv6577n54 CNV loss 21841781
dgv6576n54 CNV gain+loss 21841781
dgv6575n54 CNV loss 21841781
dgv6574n54 CNV loss 21841781
dgv6573n54 CNV gain+loss 21841781
dgv6572n54 CNV loss 21841781
dgv6571n54 CNV gain+loss 21841781
dgv6570n54 CNV loss 21841781
dgv6569n54 CNV gain 21841781
dgv6568n54 CNV loss 21841781
dgv6567n54 CNV loss 21841781
dgv6566n54 CNV loss 21841781
dgv6565n54 CNV loss 21841781
dgv6564n54 CNV gain 21841781
dgv537e201 CNV deletion 23290073
dgv536e201 CNV deletion 23290073
dgv535e201 CNV deletion 23290073
dgv534e201 CNV deletion 23290073
dgv3672n100 CNV gain+loss 25217958
dgv3671n100 CNV gain+loss 25217958
dgv3670n100 CNV loss 25217958
dgv3669n100 CNV gain 25217958
dgv3668n100 CNV loss 25217958
dgv3667n100 CNV gain 25217958
dgv3666n100 CNV gain 25217958
dgv1818n106 CNV deletion 24896259
dgv16e196 CNV duplication 17116639
dgv149n111 CNV deletion 26073780
dgv145e55 CNV loss 17911159
dgv144e55 CNV gain 17911159
dgv1083e212 CNV loss 25503493
dgv1082e212 CNV loss 25503493
dgv1081e212 CNV loss 25503493
dgv1080e212 CNV loss 25503493
dgv1079e212 CNV loss 25503493
dgv1078e212 CNV gain 25503493

Additional Variant Information for KIR2DL2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for KIR2DL2 Gene

Disorders for KIR2DL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIR2DL2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • active stage trachoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KIR2DL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIR2DL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIR2DL2 Gene

Publications for KIR2DL2 Gene

  1. Association of KIR2DL2 polymorphism rs2756923 with type 1 diabetes and preliminary evidence for lack of inhibition through HLA-C1 ligand binding. (PMID: 19392800) Ramos-Lopez E … Badenhoop K (Tissue antigens 2009) 3 22 44 58
  2. Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia. (PMID: 19493232) Middleton D … Gourraud PA (Tissue antigens 2009) 3 22 44 58
  3. Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand. (PMID: 19789864) Hollenbach JA … Trachtenberg EA (Immunogenetics 2009) 3 22 44 58
  4. Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients. (PMID: 19877200) Askar M … Zein NN (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2009) 3 22 44 58
  5. KIR haplotype content at the allele level in 77 Northern Irish families. (PMID: 17200871) Middleton D … Gourraud PA (Immunogenetics 2007) 3 22 44 58

Products for KIR2DL2 Gene

Sources for KIR2DL2 Gene

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