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Aliases for KIFC3 Gene

Aliases for KIFC3 Gene

  • Kinesin Family Member C3 2 3 5
  • Kinesin-Like Protein KIFC3 3

External Ids for KIFC3 Gene

Previous GeneCards Identifiers for KIFC3 Gene

  • GC16M048187
  • GC16M057877
  • GC16M057526
  • GC16M057567
  • GC16M056349
  • GC16M057792
  • GC16M043659

Summaries for KIFC3 Gene

Entrez Gene Summary for KIFC3 Gene

  • This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for KIFC3 Gene

KIFC3 (Kinesin Family Member C3) is a Protein Coding gene. Diseases associated with KIFC3 include Bardet-Biedl Syndrome. Among its related pathways are Metabolism of proteins and Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC2.

UniProtKB/Swiss-Prot for KIFC3 Gene

  • Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.

Gene Wiki entry for KIFC3 Gene

Additional gene information for KIFC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC3 Gene

Genomics for KIFC3 Gene

GeneHancer (GH) Regulatory Elements for KIFC3 Gene

Promoters and enhancers for KIFC3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J057795 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.2 +63.0 62968 10 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 KIFC3 LOC388282 CNOT1 RSPRY1 SETD6 GC16M057830 RNU6-20P GC16P057760
GH16J057790 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 665.1 +71.4 71422 1.5 SP1 KLF1 RXRA MAX REST HNF4A RAD21 NR2F2 YY1 KIFC3 LOC388282 MIR6772 GC16P057760
GH16J057861 Enhancer 1.2 Ensembl ENCODE 650.7 +0.0 30 2.2 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 TCF12 ATF7 KIFC3 CNOT1 RSPRY1 SETD6 POLR2C GC16M057828
GH16J057756 Enhancer 1.1 ENCODE dbSUPER 18.6 +106.0 105981 1.9 HDGF ARID4B SIN3A ZNF48 GLIS2 ARID2 ZNF143 ATF7 KLF13 DEK KIFC3 LOC388282 ENSG00000276166 GC16M057746 KATNB1
GH16J057763 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.6 +98.7 98716 2.5 HDGF PKNOX1 SIN3A KLF14 ZNF335 ZNF366 SCRT2 RCOR1 FOS ATF7 LOC101927556 KIFC3 RSPRY1 GC16P057760 GC16P057766
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIFC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIFC3 gene promoter:
  • Arnt
  • LCR-F1
  • c-Myb
  • p53
  • CUTL1
  • NF-AT

Genomic Locations for KIFC3 Gene

Genomic Locations for KIFC3 Gene
104,837 bases
Minus strand
104,829 bases
Minus strand

Genomic View for KIFC3 Gene

Genes around KIFC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIFC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIFC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFC3 Gene

Proteins for KIFC3 Gene

  • Protein details for KIFC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIFC3
    Protein Accession:
    Secondary Accessions:
    • A8K6S2
    • B7Z484
    • O75299
    • Q49A29
    • Q49AQ0
    • Q59G19
    • Q8IUT3
    • Q96HW6

    Protein attributes for KIFC3 Gene

    833 amino acids
    Molecular mass:
    92775 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34234.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH41132.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH47051.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAD92527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIFC3 Gene

    Alternative splice isoforms for KIFC3 Gene


neXtProt entry for KIFC3 Gene

Post-translational modifications for KIFC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIFC3 Gene

Domains & Families for KIFC3 Gene

Gene Families for KIFC3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIFC3: view

Function for KIFC3 Gene

Molecular function for KIFC3 Gene

UniProtKB/Swiss-Prot Function:
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.
GENATLAS Biochemistry:
kinesin,heavy chain member C3,microtubule associated protein,ATP dependent superfamily,highly expressed in the retina and retinal pigment epithelium,homolog to morone saxatilus FKIF2

Phenotypes From GWAS Catalog for KIFC3 Gene

Gene Ontology (GO) - Molecular Function for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA,TAS 9782090
GO:0005515 protein binding IPI 20360068
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIFC3: view
genes like me logo Genes that share phenotypes with KIFC3: view

Animal Models for KIFC3 Gene

MGI Knock Outs for KIFC3:

Animal Model Products

Clone Products

  • Addgene plasmids for KIFC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIFC3 Gene

Localization for KIFC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC3 Gene

Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell-cell contacts. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIFC3 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 3
golgi apparatus 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA 19041755
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIFC3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIFC3 Gene

Pathways & Interactions for KIFC3 Gene

genes like me logo Genes that share pathways with KIFC3: view

Gene Ontology (GO) - Biological Process for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
GO:0007018 microtubule-based movement IBA,IEA --
GO:0007030 Golgi organization IEA --
GO:0007601 visual perception TAS 9782090
GO:0045218 zonula adherens maintenance IMP 19041755
genes like me logo Genes that share ontologies with KIFC3: view

No data available for SIGNOR curated interactions for KIFC3 Gene

Drugs & Compounds for KIFC3 Gene

No Compound Related Data Available

Transcripts for KIFC3 Gene

Unigene Clusters for KIFC3 Gene

Kinesin family member C3:
Representative Sequences:

Clone Products

  • Addgene plasmids for KIFC3

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1: - - -
SP2: - - - -
SP3: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - - - -

ExUns: 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP11: -
SP16: - -
SP17: -

Relevant External Links for KIFC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIFC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIFC3 Gene

Protein differential expression in normal tissues from HIPED for KIFC3 Gene

This gene is overexpressed in Monocytes (23.5), Peripheral blood mononuclear cells (13.1), Testis (13.0), and Adipocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIFC3 Gene

Protein tissue co-expression partners for KIFC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIFC3 Gene:


SOURCE GeneReport for Unigene cluster for KIFC3 Gene:


Evidence on tissue expression from TISSUES for KIFC3 Gene

  • Nervous system(4.7)
  • Eye(4.3)
  • Muscle(4.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with KIFC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIFC3 Gene

Orthologs for KIFC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIFC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIFC3 34 33
  • 97.42 (n)
(Canis familiaris)
Mammalia KIFC3 34 33
  • 91.36 (n)
(Bos Taurus)
Mammalia KIFC3 34 33
  • 91.31 (n)
(Rattus norvegicus)
Mammalia Kifc3 33
  • 88.78 (n)
(Mus musculus)
Mammalia Kifc3 16 34 33
  • 87.5 (n)
(Ornithorhynchus anatinus)
Mammalia KIFC3 34
  • 81 (a)
(Monodelphis domestica)
Mammalia KIFC3 34
  • 79 (a)
(Gallus gallus)
Aves KIFC3 34 33
  • 81.22 (n)
(Anolis carolinensis)
Reptilia KIFC3 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kifc3 33
  • 60.22 (n)
(Danio rerio)
Actinopterygii kifc3 34 33
  • 66.34 (n)
wufc51b05 33
fruit fly
(Drosophila melanogaster)
Insecta ncd 34 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea klp-3 35
  • 45 (a)
klp-16 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 34
  • 25 (a)
(Hordeum vulgare)
Liliopsida Hv.2916 33
(Triticum aestivum)
Liliopsida Ta.8288 33
(Oryza sativa)
Liliopsida Os.24220 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
Cin.10026 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10026 33
Species where no ortholog for KIFC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KIFC3 Gene

Gene Tree for KIFC3 (if available)
Gene Tree for KIFC3 (if available)
Evolutionary constrained regions (ECRs) for KIFC3: view image

Paralogs for KIFC3 Gene

Paralogs for KIFC3 Gene

(24) SIMAP similar genes for KIFC3 Gene using alignment to 19 proteins:

  • B7Z484_HUMAN
  • B7Z896_HUMAN
  • F5H3M2_HUMAN
  • F5H4I9_HUMAN
  • H3BV47_HUMAN
genes like me logo Genes that share paralogs with KIFC3: view

Variants for KIFC3 Gene

Sequence variations from dbSNP and Humsavar for KIFC3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000060520 -- 57,815,296(-) C/A/G/T genic_upstream_transcript_variant, intron_variant
rs1000083313 -- 57,795,635(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000128749 -- 57,861,340(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000159371 -- 57,787,440(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000178218 -- 57,842,401(-) A/C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIFC3 Gene

Variant ID Type Subtype PubMed ID
nsv1112692 CNV deletion 24896259
nsv471089 CNV loss 18288195
nsv509622 CNV insertion 20534489
nsv523237 CNV loss 19592680
nsv525464 CNV gain 19592680
nsv526855 CNV loss 19592680
nsv528250 CNV loss 19592680
nsv817732 CNV loss 17921354
nsv952038 CNV deletion 24416366

Variation tolerance for KIFC3 Gene

Residual Variation Intolerance Score: 4.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIFC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFC3 Gene

Disorders for KIFC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIFC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search KIFC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIFC3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIFC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIFC3 Gene

Publications for KIFC3 Gene

  1. Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome. (PMID: 9782090) Hoang EH … Burnside B (Genomics 1998) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. (PMID: 19041755) Meng W … Takeichi M (Cell 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for KIFC3 Gene

  • Addgene plasmids for KIFC3

Sources for KIFC3 Gene

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