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Aliases for KIFC1 Gene

Aliases for KIFC1 Gene

  • Kinesin Family Member C1 2 3 5
  • Kinesin-Related Protein HSET 3 4
  • Kinesin-Like Protein 2 3 4
  • Kinesin-Like 2 2 3
  • KNSL2 3 4
  • HSET 3 4
  • Kinesin-Like Protein KIFC1 3

External Ids for KIFC1 Gene

Previous HGNC Symbols for KIFC1 Gene

  • KNSL2

Previous GeneCards Identifiers for KIFC1 Gene

  • GC06P033355
  • GC06P033406
  • GC06P033466
  • GC06P033101

Summaries for KIFC1 Gene

GeneCards Summary for KIFC1 Gene

KIFC1 (Kinesin Family Member C1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC3.

UniProtKB/Swiss-Prot for KIFC1 Gene

  • Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

Gene Wiki entry for KIFC1 Gene

Additional gene information for KIFC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC1 Gene

Genomics for KIFC1 Gene

GeneHancer (GH) Regulatory Elements for KIFC1 Gene

Promoters and enhancers for KIFC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I033390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.1 1121 4.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 KIFC1 DAXX BRD2 LEMD2 RXRB RGL2 WDR46 VPS52 RPS18 HLA-DOB
GH06I033423 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +35.5 35461 6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 DAXX LEMD2 BRD2 WDR46 RXRB VPS52 RGL2 SYNGAP1 KIFC1 RPS10
GH06I034223 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.1 +832.9 832913 2.7 HDGF SMAD1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 IRF4 POLR2B RPS10 VPS52 TAF11 DAXX LEMD2 WDR46 ITPR3 RGL2 KIFC1 HCG25
GH06I033341 Enhancer 1.5 FANTOM5 Ensembl ENCODE 20.7 -47.6 -47552 4 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZNF213 E2F8 ZNF207 ZNF143 REST DAXX WDR46 TAPBP BRD2 LEMD2 RGL2 PHF1 KIFC1 HCG25 B3GALT4
GH06I033311 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -73.3 -73338 13 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 DAXX TAPBP ZBTB22 VPS52 RING1 PHF1 HCG25 WDR46 PFDN6 B3GALT4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIFC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIFC1 gene promoter:

Genomic Locations for KIFC1 Gene

Genomic Locations for KIFC1 Gene
18,703 bases
Plus strand

Genomic View for KIFC1 Gene

Genes around KIFC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIFC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFC1 Gene

Proteins for KIFC1 Gene

  • Protein details for KIFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIFC1
    Protein Accession:
    Secondary Accessions:
    • O60887
    • Q14834
    • Q4KMP0
    • Q5SU09
    • Q6GMS7
    • Q6P4A5
    • Q9UQP7

    Protein attributes for KIFC1 Gene

    673 amino acids
    Molecular mass:
    73748 Da
    Quaternary structure:
    • Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).
    • HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.
    • Sequence=AAH00712.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63567.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH73878.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98438.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03509.1; Type=Frameshift; Positions=223, 256; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIFC1 Gene

neXtProt entry for KIFC1 Gene

Post-translational modifications for KIFC1 Gene

  • Ubiquitination at isoforms=308, isoforms=511, isoforms=619, and isoforms=659
  • Modification sites at PhosphoSitePlus

Other Protein References for KIFC1 Gene

No data available for DME Specific Peptides for KIFC1 Gene

Domains & Families for KIFC1 Gene

Gene Families for KIFC1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIFC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
genes like me logo Genes that share domains with KIFC1: view

Function for KIFC1 Gene

Molecular function for KIFC1 Gene

UniProtKB/Swiss-Prot Function:
Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

Phenotypes From GWAS Catalog for KIFC1 Gene

Gene Ontology (GO) - Molecular Function for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity NAS,IEA 8276466
GO:0005524 ATP binding IEA,NAS 8276466
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIFC1: view
genes like me logo Genes that share phenotypes with KIFC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIFC1 Gene

Localization for KIFC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC1 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Early endosome. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. {ECO:0000250 UniProtKB:Q9QWT9}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIFC1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
endosome 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with KIFC1: view

Pathways & Interactions for KIFC1 Gene

genes like me logo Genes that share pathways with KIFC1: view

Gene Ontology (GO) - Biological Process for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation NAS 8276466
GO:0007018 microtubule-based movement IBA,IEA --
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IMP 15843429
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with KIFC1: view

No data available for SIGNOR curated interactions for KIFC1 Gene

Drugs & Compounds for KIFC1 Gene

(1) Drugs for KIFC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0
genes like me logo Genes that share compounds with KIFC1: view

Transcripts for KIFC1 Gene

Unigene Clusters for KIFC1 Gene

Kinesin family member C1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC1 Gene

No ASD Table

Relevant External Links for KIFC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIFC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIFC1 Gene

This gene is overexpressed in Testis (x4.6) and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for KIFC1 Gene

This gene is overexpressed in Breast (47.7), Testis (9.6), and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIFC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIFC1 Gene:


SOURCE GeneReport for Unigene cluster for KIFC1 Gene:


Evidence on tissue expression from TISSUES for KIFC1 Gene

  • Kidney(4.1)
  • Muscle(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KIFC1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIFC1 Gene

Orthologs for KIFC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIFC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIFC1 33 34
  • 99.6 (n)
(Bos Taurus)
Mammalia KIFC1 33 34
  • 86.67 (n)
(Canis familiaris)
Mammalia KIFC1 33 34
  • 86.31 (n)
(Rattus norvegicus)
Mammalia Kifc1 33
  • 81.21 (n)
(Mus musculus)
Mammalia Kifc1 33 34
  • 80.97 (n)
Kifc5b 16 34
  • 78 (a)
(Monodelphis domestica)
Mammalia KIFC1 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia KIFC1 34
  • 31 (a)
(Gallus gallus)
Aves KIFC1 33
  • 59.11 (n)
-- 34
  • 54 (a)
-- 34
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
-- 34
  • 39 (a)
-- 34
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kifc1 33
  • 53.54 (n)
(Danio rerio)
Actinopterygii kifc1 33 34
  • 53.58 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta ncd 33
  • 48.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002248 33
  • 47.7 (n)
(Caenorhabditis elegans)
Secernentea klp-17 34
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 34
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATK5 33
  • 51.06 (n)
(Oryza sativa)
Liliopsida Os04g0629700 33
  • 49.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04581 33
  • 50.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11354 34
  • 47 (a)
Species where no ortholog for KIFC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIFC1 Gene

Gene Tree for KIFC1 (if available)
Gene Tree for KIFC1 (if available)

Paralogs for KIFC1 Gene

Variants for KIFC1 Gene

Sequence variations from dbSNP and Humsavar for KIFC1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs752059822 benign, not specified 33,409,704(+) TCT/T/TCTCT/TCTCTCT/TCTCTCTCT/TCTCTGTCT 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000079989 -- 33,391,730(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000229944 -- 33,401,248(+) C/A intron_variant
rs1000420976 -- 33,408,691(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000449187 -- 33,395,466(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIFC1 Gene

Variant ID Type Subtype PubMed ID
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv830635 CNV loss 17160897
nsv830637 CNV loss 17160897
nsv969387 CNV duplication 23825009

Variation tolerance for KIFC1 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIFC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFC1 Gene

Disorders for KIFC1 Gene

Additional Disease Information for KIFC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KIFC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIFC1 Gene

Publications for KIFC1 Gene

  1. Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region. (PMID: 8276466) Ando A … Abe K (Immunogenetics 1994) 2 3 4 22 58
  2. Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS). (PMID: 10369922) Janitz K … Volz A (Immunogenetics 1999) 3 4 22 58
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  4. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PMID: 15843429) Zhu C … Jiang W (Molecular biology of the cell 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for KIFC1 Gene

  • Addgene plasmids for KIFC1

Sources for KIFC1 Gene

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