Aliases for KIFAP3 Gene
External Ids for KIFAP3 Gene
Previous GeneCards Identifiers for KIFAP3 Gene
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for KIFAP3 Gene
KIFAP3 (Kinesin Associated Protein 3) is a Protein Coding gene. Diseases associated with KIFAP3 include Progressive Bulbar Palsy and Amyotrophic Lateral Sclerosis 1. Among its related pathways are G-protein signaling_RhoA regulation pathway and Translocation of GLUT4 to the plasma membrane. Gene Ontology (GO) annotations related to this gene include binding and kinesin binding.
UniProtKB/Swiss-Prot Summary for KIFAP3 Gene
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).