Aliases for KIFAP3 Gene
External Ids for KIFAP3 Gene
Previous GeneCards Identifiers for KIFAP3 Gene
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for KIFAP3 Gene
KIFAP3 (Kinesin Associated Protein 3) is a Protein Coding gene. Diseases associated with KIFAP3 include Progressive Bulbar Palsy and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Organelle biogenesis and maintenance and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include binding and kinesin binding.
UniProtKB/Swiss-Prot Summary for KIFAP3 Gene
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).