Aliases for KIF5C Gene
External Ids for KIF5C Gene
Previous GeneCards Identifiers for KIF5C Gene
The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]
GeneCards Summary for KIF5C Gene
KIF5C (Kinesin Family Member 5C) is a Protein Coding gene. Diseases associated with KIF5C include Cortical Dysplasia, Complex, With Other Brain Malformations 2 and Mbd5 Haploinsufficiency. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Prion disease. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5B.
UniProtKB/Swiss-Prot Summary for KIF5C Gene
Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).