The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malforma... See more...

Aliases for KIF5C Gene

Aliases for KIF5C Gene

  • Kinesin Family Member 5C 2 3 5
  • Kinesin Heavy Chain Neuron-Specific 2 3 4
  • Kinesin Heavy Chain Isoform 5C 3 4
  • NKHC2 3 4
  • Kinesin Heavy Chain 3
  • KIAA0531 4
  • CDCBM2 3
  • NKHC-2 3
  • KIF5C 5
  • KINN 3
  • NKHC 3

External Ids for KIF5C Gene

Previous GeneCards Identifiers for KIF5C Gene

  • GC02M148723
  • GC02M149409
  • GC02P149805
  • GC02P149996
  • GC02P149466
  • GC02P149349
  • GC02P149632
  • GC02P141630

Summaries for KIF5C Gene

Entrez Gene Summary for KIF5C Gene

  • The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]

GeneCards Summary for KIF5C Gene

KIF5C (Kinesin Family Member 5C) is a Protein Coding gene. Diseases associated with KIF5C include Cortical Dysplasia, Complex, With Other Brain Malformations 2 and Mbd5 Haploinsufficiency. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Prion disease. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5B.

UniProtKB/Swiss-Prot Summary for KIF5C Gene

  • Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).

Gene Wiki entry for KIF5C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF5C Gene

Genomics for KIF5C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIF5C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J148875 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 267.2 +0.7 692 3 ZNF600 SIX5 JUND ZNF580 ATF2 CEBPA POLR2A ETS1 ZNF341 SIN3A KIF5C piR-31637-002 KIF5C-AS1 LYPD6B
GH02J148947 Promoter 0.3 EPDnew 250.2 +72.6 72629 0.1 KIF5C KIF5C-AS1 LOC101928553 HSALNG0019513 LYPD6B
GH02J148926 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +51.8 51767 1.6 TRIM22 CTCF ARNT RAD21 SMC3 GABPB1 SPI1 ZNF24 ZBTB33 RBM39 ENSG00000286167 KIF5C-AS1 lnc-MMADHC-6 USP8P2 KIF5C RPS20P13 LYPD6B LOC101928553 FJ770973
GH02J148812 Enhancer 1 Ensembl ENCODE 10.9 -61.0 -61026 4.4 BCLAF1 SP1 ZNF580 POLR2A BCL11A TRIM22 CTCF SIN3A IRF4 YY1 HSALNG0019508 HSALNG0019509 KIF5C-AS1 RPS20P13 USP8P2 KIF5C EPC2
GH02J149068 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +194.5 194474 3.4 ZNF217 CEBPB FEZF1 MAX EP300 MBD2 ELF1 CTBP1 CUX1 TAL1 TXNP5 lnc-MMADHC-5 LYPD6B KIF5C lnc-LYPD6B-1 LOC105373678 LYPD6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF5C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF5C

Top Transcription factor binding sites by QIAGEN in the KIF5C gene promoter:
  • AREB6
  • CUTL1
  • FOXF2
  • GATA-1
  • Gfi-1
  • GR-alpha
  • GR-beta
  • NF-1
  • NF-kappaB1
  • YY1

Genomic Locations for KIF5C Gene

Latest Assembly
chr2:148,875,227-149,026,759
(GRCh38/hg38)
Size:
151,533 bases
Orientation:
Plus strand

Previous Assembly
chr2:149,632,796-149,883,273
(GRCh37/hg19 by Entrez Gene)
Size:
250,478 bases
Orientation:
Plus strand

chr2:149,632,819-149,883,273
(GRCh37/hg19 by Ensembl)
Size:
250,455 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr2(ALT_REF_LOCI_1):3,214-96,131 (+)

Genomic View for KIF5C Gene

Genes around KIF5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF5C Gene

Proteins for KIF5C Gene

  • Protein details for KIF5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60282-KIF5C_HUMAN
    Recommended name:
    Kinesin heavy chain isoform 5C
    Protein Accession:
    O60282
    Secondary Accessions:
    • O95079
    • Q2YDC5

    Protein attributes for KIF5C Gene

    Size:
    957 amino acids
    Molecular mass:
    109495 Da
    Quaternary structure:
    • Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3 (By similarity). Interacts with TRAK1 (PubMed:15644324). Interacts with ZFYVE27 (By similarity).
    SequenceCaution:
    • Sequence=BAA25457.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF5C Gene

Post-translational modifications for KIF5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF5C Gene

Domains & Families for KIF5C Gene

Gene Families for KIF5C Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIF5C Gene

InterPro:
Blocks:
  • Kinesin, motor region

Suggested Antigen Peptide Sequences for KIF5C Gene

GenScript: Design optimal peptide antigens:
  • KIF5C protein (A1L179_HUMAN)
  • Kinesin heavy chain neuron-specific 2 (KIF5C_HUMAN)
  • KIF5C protein (Q6PJC4_HUMAN)
  • KIF5C protein (Q6PKD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60282

UniProtKB/Swiss-Prot:

KIF5C_HUMAN :
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
Domain:
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
genes like me logo Genes that share domains with KIF5C: view

Function for KIF5C Gene

Molecular function for KIF5C Gene

UniProtKB/Swiss-Prot Function:
Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).

Phenotypes From GWAS Catalog for KIF5C Gene

Gene Ontology (GO) - Molecular Function for KIF5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003777 microtubule motor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 15644324
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with KIF5C: view
genes like me logo Genes that share phenotypes with KIF5C: view

Human Phenotype Ontology for KIF5C Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KIF5C Gene

MGI Knock Outs for KIF5C:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF5C

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KIF5C Gene

Localization for KIF5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF5C Gene

Cytoplasm, cytoskeleton. Cell projection, dendrite. Note=Abundant in distal regions of dendrites. {ECO:0000269 PubMed:24812067}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF5C gene
Compartment Confidence
cytoskeleton 4
cytosol 4
plasma membrane 3
nucleus 3
mitochondrion 2
peroxisome 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KIF5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex TAS,IBA 21873635
GO:0005874 microtubule IBA 21873635
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with KIF5C: view

Pathways & Interactions for KIF5C Gene

genes like me logo Genes that share pathways with KIF5C: view

Pathways by source for KIF5C Gene

1 GeneGo (Thomson Reuters) pathway for KIF5C Gene
  • Cytoskeleton remodeling Neurofilaments

SIGNOR curated interactions for KIF5C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for KIF5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS 9782088
GO:0007018 microtubule-based movement IEA,IBA 21873635
GO:0007411 axon guidance IBA 21873635
GO:0008045 motor neuron axon guidance IEA --
GO:0030705 cytoskeleton-dependent intracellular transport IBA 21873635
genes like me logo Genes that share ontologies with KIF5C: view

Drugs & Compounds for KIF5C Gene

No Compound Related Data Available

Transcripts for KIF5C Gene

mRNA/cDNA for KIF5C Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
37 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF5C

Alternative Splicing Database (ASD) splice patterns (SP) for KIF5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KIF5C Gene

GeneLoc Exon Structure for
KIF5C

Expression for KIF5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF5C Gene

This gene is overexpressed in Brain - Amygdala (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.1), Brain - Cortex (x5.0), Brain - Frontal Cortex (BA9) (x4.7), Brain - Hippocampus (x4.6), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for KIF5C Gene

This gene is overexpressed in Fetal Brain (26.7), Frontal cortex (9.2), Brain (8.2), Ovary (6.8), and Spinal cord (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF5C Gene



Protein tissue co-expression partners for KIF5C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF5C

SOURCE GeneReport for Unigene cluster for KIF5C Gene:

Hs.435557

mRNA Expression by UniProt/SwissProt for KIF5C Gene:

O60282-KIF5C_HUMAN
Tissue specificity: Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.

Evidence on tissue expression from TISSUES for KIF5C Gene

  • Nervous system(5)
  • Lung(2.5)
  • Kidney(2.5)
  • Eye(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF5C Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • head
  • skull
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • spinal cord
genes like me logo Genes that share expression patterns with KIF5C: view

Primer products for research

Orthologs for KIF5C Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF5C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIF5C 29 30
  • 99.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KIF5C 29 30
  • 93.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIF5C 29 30
  • 92.76 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KIF5C 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kif5c 29
  • 90.12 (n)
Mouse
(Mus musculus)
Mammalia Kif5c 29 16 30
  • 89.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 31 (a)
OneToMany
Chicken
(Gallus gallus)
Aves KIF5C 29 30
  • 84.41 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIF5C 30
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kif5c 29
  • 78.33 (n)
Str.12975 29
Zebrafish
(Danio rerio)
Actinopterygii kif5c 29 30
  • 73.99 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Khc 30
  • 61 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea unc-116 30
  • 54 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 63 (a)
OneToMany
Species where no ortholog for KIF5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KIF5C Gene

ENSEMBL:
Gene Tree for KIF5C (if available)
TreeFam:
Gene Tree for KIF5C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF5C: view image
Alliance of Genome Resources:
Additional Orthologs for KIF5C

Paralogs for KIF5C Gene

genes like me logo Genes that share paralogs with KIF5C: view

Variants for KIF5C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF5C Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
871538 Likely Benign: not provided 148,978,948(+) G/A
NM_004522.3(KIF5C):c.1320G>A (p.Gln440=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
871539 Uncertain Significance: not provided 149,010,315(+) A/G
NM_004522.3(KIF5C):c.2731A>G (p.Lys911Glu)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
930842 Uncertain Significance: Cortical dysplasia, complex, with other brain malformations 2 148,983,775(+) G/A
NM_004522.3(KIF5C):c.1716+9G>A
INTRON
977878 Likely Benign: Cortical dysplasia, complex, with other brain malformations 2 149,010,244(+) A/G
NM_004522.3(KIF5C):c.2660A>G (p.Lys887Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1057523537 Likely Benign: not specified 148,941,598(+) G/C
NM_004522.3(KIF5C):c.397-12G>C
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KIF5C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KIF5C Gene

Variant ID Type Subtype PubMed ID
esv2664279 CNV deletion 23128226
esv2751831 CNV gain 17911159
esv3592853 CNV loss 21293372
nsv2963 CNV insertion 18451855
nsv473264 CNV novel sequence insertion 20440878
nsv473956 CNV novel sequence insertion 20440878
nsv475150 CNV novel sequence insertion 20440878
nsv479307 CNV novel sequence insertion 20440878
nsv479767 CNV novel sequence insertion 20440878
nsv479910 CNV novel sequence insertion 20440878
nsv480410 CNV novel sequence insertion 20440878
nsv480451 CNV novel sequence insertion 20440878
nsv480911 CNV novel sequence insertion 20440878
nsv508874 CNV insertion 20534489
nsv834407 CNV loss 17160897
nsv834408 CNV gain 17160897
nsv955264 CNV deletion 24416366
nsv979133 CNV duplication 23825009

Variation tolerance for KIF5C Gene

Gene Damage Index Score: 2.02; 37.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF5C Gene

Human Gene Mutation Database (HGMD)
KIF5C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF5C
Leiden Open Variation Database (LOVD)
KIF5C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF5C Gene

Disorders for KIF5C Gene

MalaCards: The human disease database

(13) MalaCards diseases for KIF5C Gene - From: OMI, CVR, GTR, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search KIF5C in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KIF5C_HUMAN
  • Cortical dysplasia, complex, with other brain malformations 2 (CDCBM2) [MIM:615282]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include intrauterine growth retardation, fetal akinesia, seizures, microcephaly, lack of psychomotor development, and arthrogryposis. Brain imaging shows malformations of cortical development, including polymicrogyria, gyral simplification, and thin corpus callosum. {ECO:0000269 PubMed:23033978, ECO:0000269 PubMed:23603762, ECO:0000269 PubMed:24812067, ECO:0000269 PubMed:29048727}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for KIF5C

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KIF5C: view

No data available for Genatlas for KIF5C Gene

Publications for KIF5C Gene

  1. Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development. (PMID: 29048727) Michels S … Mirzaa GM (American journal of medical genetics. Part A 2017) 3 4
  2. Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function. (PMID: 24812067) Willemsen MH … Kleefstra T (Journal of medical genetics 2014) 3 4
  3. Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. (PMID: 23603762) Poirier K … Chelly J (Nature genetics 2013) 4 72
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K … Stephenson FA (The Journal of biological chemistry 2005) 3 4

Products for KIF5C Gene

Sources for KIF5C Gene