Aliases for KIF5B Gene
External Ids for KIF5B Gene
Previous HGNC Symbols for KIF5B Gene
Previous GeneCards Identifiers for KIF5B Gene
GeneCards Summary for KIF5B Gene
KIF5B (Kinesin Family Member 5B) is a Protein Coding gene. Diseases associated with KIF5B include Pulmonary Large Cell Neuroendocrine Carcinoma and Large Cell Neuroendocrine Carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.
UniProtKB/Swiss-Prot Summary for KIF5B Gene
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).