Aliases for KIF5A Gene
External Ids for KIF5A Gene
Previous HGNC Symbols for KIF5A Gene
Previous GeneCards Identifiers for KIF5A Gene
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]
GeneCards Summary for KIF5A Gene
KIF5A (Kinesin Family Member 5A) is a Protein Coding gene. Diseases associated with KIF5A include Spastic Paraplegia 10, Autosomal Dominant and Myoclonus, Intractable, Neonatal. Among its related pathways are Peptide hormone metabolism and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.
UniProtKB/Swiss-Prot for KIF5A Gene
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.