This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. [provided by RefSeq, Jul 2016] See more...

Aliases for KIF4B Gene

Aliases for KIF4B Gene

  • Kinesin Family Member 4B 2 3 5
  • Chromosome-Associated Kinesin KIF4B 3 4
  • Chromokinesin-B 3 4

External Ids for KIF4B Gene

Previous GeneCards Identifiers for KIF4B Gene

  • GC05U990137
  • GC05P154374
  • GC05P154393
  • GC05P149535

Summaries for KIF4B Gene

Entrez Gene Summary for KIF4B Gene

  • This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. [provided by RefSeq, Jul 2016]

GeneCards Summary for KIF4B Gene

KIF4B (Kinesin Family Member 4B) is a Protein Coding gene. Among its related pathways are Endocytic Trafficking of EGFR and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF4A.

UniProtKB/Swiss-Prot Summary for KIF4B Gene

  • Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).

Additional gene information for KIF4B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF4B Gene

Genomics for KIF4B Gene

GeneHancer (GH) Regulatory Elements for KIF4B Gene

Promoters and enhancers for KIF4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J155013 Promoter 0.4 Ensembl 500.7 +0.2 201 0.6 NRF1 KIF4B RF00017-5034
GH05J154936 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 -73.9 -73899 6.4 HNRNPK ZBTB40 ZNF217 EP300 TCF12 SIN3A MYC NRF1 POLR2G USF1 GEMIN5 MRPL22 SAP30L-AS1 KIF4B CNOT8
GH05J155049 Enhancer 0.7 Ensembl ENCODE 11.3 +36.2 36201 1.8 CTCF TEAD4 SMC3 WT1 ZBTB17 POLR2A FOXP2 FEZF1 GLIS1 RAD21 KIF4B RF00017-5034
GH05J155084 Enhancer 0.8 Ensembl ENCODE 10.6 +73.1 73092 3.7 ZNF217 ZSCAN5C RFX1 CTBP1 ESRRA GATA3 PKNOX1 DPF2 ATF2 ESR1 ENSG00000287963 RF01045-124 KIF4B CNOT8
GH05J154970 Enhancer 0.7 Ensembl 11 -42.9 -42899 0.8 FOXA2 SAP130 ZNF205 MXD4 FOXP1 FOS SMAD4 ZGPAT MAX FOSL2 KIF4B piR-33730-078 RF00017-5033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF4B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF4B

Top Transcription factor binding sites by QIAGEN in the KIF4B gene promoter:
  • Brachyury
  • C/EBPalpha
  • GATA-1
  • GATA-2
  • GATA-3
  • HNF-3beta
  • Meis-1
  • MyoD
  • NF-1
  • NF-1/L

Genomic Locations for KIF4B Gene

Genomic Locations for KIF4B Gene
chr5:155,013,700-155,018,141
(GRCh38/hg38)
Size:
4,442 bases
Orientation:
Plus strand
chr5:154,393,260-154,397,685
(GRCh37/hg19)
Size:
4,426 bases
Orientation:
Plus strand

Genomic View for KIF4B Gene

Genes around KIF4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF4B Gene

Proteins for KIF4B Gene

  • Protein details for KIF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VIQ3-KIF4B_HUMAN
    Recommended name:
    Chromosome-associated kinesin KIF4B
    Protein Accession:
    Q2VIQ3

    Protein attributes for KIF4B Gene

    Size:
    1234 amino acids
    Molecular mass:
    140035 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIF4B Gene

Post-translational modifications for KIF4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF4B Gene

Domains & Families for KIF4B Gene

Gene Families for KIF4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF4B Gene

GenScript: Design optimal peptide antigens:
  • Chromokinesin-B (KIF4B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2VIQ3

UniProtKB/Swiss-Prot:

KIF4B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
genes like me logo Genes that share domains with KIF4B: view

Function for KIF4B Gene

Molecular function for KIF4B Gene

UniProtKB/Swiss-Prot Function:
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).

Phenotypes From GWAS Catalog for KIF4B Gene

Gene Ontology (GO) - Molecular Function for KIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003777 microtubule motor activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IBA 21873635
GO:0016887 ATPase activity IBA 21873635
genes like me logo Genes that share ontologies with KIF4B: view
genes like me logo Genes that share phenotypes with KIF4B: view

Animal Model Products

CRISPR Products

miRNA for KIF4B Gene

miRTarBase miRNAs that target KIF4B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF4B Gene

Localization for KIF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF4B Gene

Nucleus matrix. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF4B gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF4B: view

Pathways & Interactions for KIF4B Gene

genes like me logo Genes that share pathways with KIF4B: view

Gene Ontology (GO) - Biological Process for KIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007052 mitotic spindle organization IBA 21873635
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with KIF4B: view

No data available for SIGNOR curated interactions for KIF4B Gene

Drugs & Compounds for KIF4B Gene

No Compound Related Data Available

Transcripts for KIF4B Gene

mRNA/cDNA for KIF4B Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF4B Gene

No ASD Table

Relevant External Links for KIF4B Gene

GeneLoc Exon Structure for
KIF4B

Expression for KIF4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF4B Gene

mRNA differential expression in normal tissues according to GTEx for KIF4B Gene

This gene is overexpressed in Testis (x40.5).

Protein differential expression in normal tissues from HIPED for KIF4B Gene

This gene is overexpressed in Platelet (60.4) and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIF4B Gene



Protein tissue co-expression partners for KIF4B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF4B

SOURCE GeneReport for Unigene cluster for KIF4B Gene:

Hs.567824

mRNA Expression by UniProt/SwissProt for KIF4B Gene:

Q2VIQ3-KIF4B_HUMAN
Tissue specificity: Specifically expressed in testis.

Evidence on tissue expression from TISSUES for KIF4B Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with KIF4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF4B Gene

Orthologs for KIF4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF4B 30
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kif4 31
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIF4A 31
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 65 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3509 30
zebrafish
(Danio rerio)
Actinopterygii KIF4A 31
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp3A 31
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-19 31
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons FRA1 30
  • 47.53 (n)
rice
(Oryza sativa)
Liliopsida Os09g0114500 30
  • 49.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for KIF4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF4B Gene

ENSEMBL:
Gene Tree for KIF4B (if available)
TreeFam:
Gene Tree for KIF4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF4B: view image

Paralogs for KIF4B Gene

(1) SIMAP similar genes for KIF4B Gene using alignment to 1 proteins:

  • KIF4B_HUMAN

Pseudogenes.org Pseudogenes for KIF4B Gene

genes like me logo Genes that share paralogs with KIF4B: view

Variants for KIF4B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF4B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs10056252 - p.Tyr684Cys
rs17116709 - p.Glu494Gln
rs17116710 - p.Arg680His
rs6580126 - p.Arg580Leu

Additional dbSNP identifiers (rs#s) for KIF4B Gene

Structural Variations from Database of Genomic Variants (DGV) for KIF4B Gene

Variant ID Type Subtype PubMed ID
esv21446 CNV gain 19812545

Variation tolerance for KIF4B Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.51; 96.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF4B Gene

Human Gene Mutation Database (HGMD)
KIF4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF4B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF4B Gene

Disorders for KIF4B Gene

Additional Disease Information for KIF4B

No disorders were found for KIF4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF4B Gene

Publications for KIF4B Gene

  1. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques AC … Kaessmann H (PLoS biology 2005) 3 4 54
  2. Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. (PMID: 10978527) Oh S … Kim W (Biochimica et biophysica acta 2000) 3 4 54
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for KIF4B Gene

Sources for KIF4B Gene