Aliases for KIF4A Gene
External Ids for KIF4A Gene
Previous GeneCards Identifiers for KIF4A Gene
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
GeneCards Summary for KIF4A Gene
KIF4A (Kinesin Family Member 4A) is a Protein Coding gene. Diseases associated with KIF4A include Mental Retardation, X-Linked 100 and Charcot-Marie-Tooth Disease, Axonal, Type 2Q. Among its related pathways are L1CAM interactions and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF4B.
UniProtKB/Swiss-Prot Summary for KIF4A Gene
Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).