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Aliases for KIF3C Gene

Aliases for KIF3C Gene

  • Kinesin Family Member 3C 2 3 5
  • Kinesin-Like Protein KIF3C 3
  • KIF3C Variant Protein 3

External Ids for KIF3C Gene

Previous GeneCards Identifiers for KIF3C Gene

  • GC02M026070
  • GC02M026242
  • GC02M026124
  • GC02M026061
  • GC02M026002
  • GC02M026149
  • GC02M025888

Summaries for KIF3C Gene

GeneCards Summary for KIF3C Gene

KIF3C (Kinesin Family Member 3C) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF3B.

UniProtKB/Swiss-Prot for KIF3C Gene

  • Microtubule-based anterograde translocator for membranous organelles.

Gene Wiki entry for KIF3C Gene

Additional gene information for KIF3C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3C Gene

Genomics for KIF3C Gene

GeneHancer (GH) Regulatory Elements for KIF3C Gene

Promoters and enhancers for KIF3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J025981 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 655.8 +0.4 383 2.3 PKNOX1 ATF1 ARID4B SIN3A ETS1 POLR2B GLIS2 ZNF143 ATF7 SP3 KIF3C NDUFB4P4
GH02J025876 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.3 +104.4 104397 2.9 HDGF PKNOX1 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ASXL2 KIF3C DTNB GC02M025821
GH02J026342 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 -363.0 -363021 6.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ADGRF3 SELENOI CAD ASXL2 TMEM214 GTF3C2-AS1 ENSG00000272148 AGBL5 KIF3C GAREM2
GH02J026011 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -29.8 -29807 3 PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 YY1 FOS RAB10 RNU6-942P KIF3C SLC35F6 GAREM2 TRMT112P6 GC02P025994 GC02M025991
GH02J025951 Enhancer 1.1 ENCODE dbSUPER 17.2 +31.5 31532 0.2 PKNOX1 ARID4B ZNF2 ZNF48 YY1 ARID2 ZNF143 RUNX3 DEK SP5 KIF3C RAB10 RNU6-942P NDUFB4P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF3C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF3C gene promoter:
  • Pax-4a
  • AhR
  • NRSF form 2
  • NRSF form 1
  • Max1
  • PPAR-gamma2
  • PPAR-gamma1
  • Egr-1
  • Max
  • c-Myc

Genomic Locations for KIF3C Gene

Genomic Locations for KIF3C Gene
chr2:25,926,586-25,982,749
(GRCh38/hg38)
Size:
56,164 bases
Orientation:
Minus strand
chr2:26,149,455-26,205,618
(GRCh37/hg19)
Size:
56,164 bases
Orientation:
Minus strand

Genomic View for KIF3C Gene

Genes around KIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3C Gene

Proteins for KIF3C Gene

  • Protein details for KIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14782-KIF3C_HUMAN
    Recommended name:
    Kinesin-like protein KIF3C
    Protein Accession:
    O14782
    Secondary Accessions:
    • O43544
    • Q4ZG18
    • Q53SX5
    • Q562F7

    Protein attributes for KIF3C Gene

    Size:
    793 amino acids
    Molecular mass:
    89426 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3C.

    Three dimensional structures from OCA and Proteopedia for KIF3C Gene

neXtProt entry for KIF3C Gene

Post-translational modifications for KIF3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF3C Gene

Antibody Products

  • Abcam antibodies for KIF3C
  • Boster Bio Antibodies for KIF3C
  • Santa Cruz Biotechnology (SCBT) Antibodies for KIF3C

No data available for DME Specific Peptides for KIF3C Gene

Domains & Families for KIF3C Gene

Gene Families for KIF3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIF3C Gene

Suggested Antigen Peptide Sequences for KIF3C Gene

Graphical View of Domain Structure for InterPro Entry

O14782

UniProtKB/Swiss-Prot:

KIF3C_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3C: view

Function for KIF3C Gene

Molecular function for KIF3C Gene

UniProtKB/Swiss-Prot Function:
Microtubule-based anterograde translocator for membranous organelles.
GENATLAS Biochemistry:
kinesin heavy chain member 3C,microtubule associated motor protein,ATP dependent superfamily,anterograde heterodimerizing motor,one transcript specifically expressed in brain,other ubiquitous

Phenotypes From GWAS Catalog for KIF3C Gene

Gene Ontology (GO) - Molecular Function for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 9480755
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF3C: view
genes like me logo Genes that share phenotypes with KIF3C: view

Animal Models for KIF3C Gene

MGI Knock Outs for KIF3C:

Animal Model Products

CRISPR Products

miRNA for KIF3C Gene

miRTarBase miRNAs that target KIF3C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF3C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3C Gene

Localization for KIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF3C gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex TAS 9480755
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF3C: view

Pathways & Interactions for KIF3C Gene

genes like me logo Genes that share pathways with KIF3C: view

Gene Ontology (GO) - Biological Process for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0030705 cytoskeleton-dependent intracellular transport IBA --
GO:0035735 intraciliary transport involved in cilium assembly TAS --
genes like me logo Genes that share ontologies with KIF3C: view

No data available for SIGNOR curated interactions for KIF3C Gene

Drugs & Compounds for KIF3C Gene

No Compound Related Data Available

Transcripts for KIF3C Gene

mRNA/cDNA for KIF3C Gene

Unigene Clusters for KIF3C Gene

Kinesin family member 3C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF3C

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for KIF3C Gene

GeneLoc Exon Structure for
KIF3C
ECgene alternative splicing isoforms for
KIF3C

Expression for KIF3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF3C Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Anterior cingulate cortex (BA24) (x5.5).

Protein differential expression in normal tissues from HIPED for KIF3C Gene

This gene is overexpressed in Brain (38.1), Cervix (9.9), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF3C Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF3C Gene:

KIF3C

SOURCE GeneReport for Unigene cluster for KIF3C Gene:

Hs.21611

Evidence on tissue expression from TISSUES for KIF3C Gene

  • Nervous system(4.6)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with KIF3C: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF3C Gene

Orthologs for KIF3C Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF3C 34 33
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIF3C 34 33
  • 92.81 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF3C 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF3C 34 33
  • 91.28 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF3C 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3c 33
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Kif3c 16 34 33
  • 89.49 (n)
chicken
(Gallus gallus)
Aves KIF3C 34 33
  • 80.59 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3c 33
  • 73.7 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01076801.1 34
  • 75 (a)
OneToMany
kif3cb 34 33
  • 63.58 (n)
OneToMany
Dr.29546 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2897 33
fruit fly
(Drosophila melanogaster)
Insecta Klp68D 34 35
  • 41 (a)
OneToMany
Kif3C 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea osm-3 35
  • 37 (a)
klp-11 34 35
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for KIF3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3C Gene

ENSEMBL:
Gene Tree for KIF3C (if available)
TreeFam:
Gene Tree for KIF3C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF3C: view image

Paralogs for KIF3C Gene

(14) SIMAP similar genes for KIF3C Gene using alignment to 6 proteins:

  • KIF3C_HUMAN
  • A2RU78_HUMAN
  • B7ZM25_HUMAN
  • F8WAR6_HUMAN
  • F8WER6_HUMAN
  • I6L9B9_HUMAN
genes like me logo Genes that share paralogs with KIF3C: view

Variants for KIF3C Gene

Sequence variations from dbSNP and Humsavar for KIF3C Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000021171 -- 25,984,036(-) T/C upstream_transcript_variant
rs1000053052 -- 25,952,998(-) G/A intron_variant
rs1000115549 -- 25,961,019(-) T/C intron_variant
rs1000125946 -- 25,952,793(-) G/C intron_variant
rs1000169939 -- 25,975,431(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF3C Gene

Variant ID Type Subtype PubMed ID
esv2659098 CNV deletion 23128226
esv33316 CNV loss 17666407
esv3554066 CNV deletion 23714750
nsv1123305 CNV deletion 24896259
nsv215114 CNV deletion 16902084

Variation tolerance for KIF3C Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF3C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3C Gene

Disorders for KIF3C Gene

Additional Disease Information for KIF3C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KIF3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF3C Gene

Publications for KIF3C Gene

  1. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. (PMID: 9480755) Sardella M … Cabibbo A (Genomics 1998) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C. (PMID: 9446808) Telford EA … Bonthron DT (Biochemical and biophysical research communications 1998) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for KIF3C Gene

Sources for KIF3C Gene

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