Aliases for KIF3C Gene

Aliases for KIF3C Gene

  • Kinesin Family Member 3C 2 3 5
  • Kinesin-Like Protein KIF3C 3 4
  • KIF3C Variant Protein 3
  • KIF3C 5

External Ids for KIF3C Gene

Previous GeneCards Identifiers for KIF3C Gene

  • GC02M026070
  • GC02M026242
  • GC02M026124
  • GC02M026061
  • GC02M026002
  • GC02M026149
  • GC02M025888

Summaries for KIF3C Gene

GeneCards Summary for KIF3C Gene

KIF3C (Kinesin Family Member 3C) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF3B.

UniProtKB/Swiss-Prot Summary for KIF3C Gene

  • Microtubule-based anterograde translocator for membranous organelles.

Gene Wiki entry for KIF3C Gene

Additional gene information for KIF3C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF3C Gene

Genomics for KIF3C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIF3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J025981 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 605.7 +0.5 549 2.8 HNRNPL TEAD4 PRDM10 TFE3 SIX5 IKZF1 PRDM1 ZNF143 ZIC2 PKNOX1 KIF3C piR-61945-269 ASXL2
GH02J025876 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 19.3 +104.9 104948 4 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST TFE3 RFX1 SIX5 ASXL2 KIF3C DNMT3A DTNB ENSG00000218682
GH02J026342 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.1 -363.0 -363021 6.3 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 REST TFE3 ADGRF3 SELENOI lnc-HADHA-4 lnc-HADHA-5 CAD TMEM214 ENSG00000272148 KIF3C GAREM2 ATRAID
GH02J026784 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.6 -803.7 -803652 3.2 SP1 HNRNPL CREB1 GATAD2A ZBTB33 ZNF629 TFE3 RFX1 NFKBIZ KDM1A CENPA NONHSAG027291.2 ATRAID GTF3C2 EIF2B4 ASXL2 GPN1 ENSG00000234072 NRBP1 TMEM214
GH02J025951 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.2 +31.5 31506 0.6 GATAD2A CTCF JUND ZNF143 RXRB REST RAD21 IRF2 ZNF501 TRIM22 piR-61945-269 KIF3C RAB10 RNU6-942P ASXL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF3C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF3C

Top Transcription factor binding sites by QIAGEN in the KIF3C gene promoter:
  • AhR
  • c-Myc
  • Egr-1
  • Max
  • Max1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KIF3C Gene

Genomic Locations for KIF3C Gene
chr2:25,926,598-25,982,749
(GRCh38/hg38)
Size:
56,152 bases
Orientation:
Minus strand
chr2:26,149,455-26,205,618
(GRCh37/hg19)
Size:
56,164 bases
Orientation:
Minus strand

Genomic View for KIF3C Gene

Genes around KIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3C Gene

Proteins for KIF3C Gene

  • Protein details for KIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14782-KIF3C_HUMAN
    Recommended name:
    Kinesin-like protein KIF3C
    Protein Accession:
    O14782
    Secondary Accessions:
    • O43544
    • Q4ZG18
    • Q53SX5
    • Q562F7

    Protein attributes for KIF3C Gene

    Size:
    793 amino acids
    Molecular mass:
    89426 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3C.

    Three dimensional structures from OCA and Proteopedia for KIF3C Gene

neXtProt entry for KIF3C Gene

Post-translational modifications for KIF3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF3C Gene

No data available for DME Specific Peptides for KIF3C Gene

Domains & Families for KIF3C Gene

Gene Families for KIF3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIF3C Gene

InterPro:
Blocks:
  • Kinesin, motor region
ProtoNet:

Suggested Antigen Peptide Sequences for KIF3C Gene

GenScript: Design optimal peptide antigens:
  • Kinesin family member 3C, isoform CRA_b (A2RU78_HUMAN)
  • KIF3C protein (B7ZM25_HUMAN)
  • Kinesin-like protein KIF3C (KIF3C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14782

UniProtKB/Swiss-Prot:

KIF3C_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3C: view

Function for KIF3C Gene

Molecular function for KIF3C Gene

UniProtKB/Swiss-Prot Function:
Microtubule-based anterograde translocator for membranous organelles.
GENATLAS Biochemistry:
kinesin heavy chain member 3C,microtubule associated motor protein,ATP dependent superfamily,anterograde heterodimerizing motor,one transcript specifically expressed in brain,other ubiquitous

Phenotypes From GWAS Catalog for KIF3C Gene

Gene Ontology (GO) - Molecular Function for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity TAS 9480755
GO:0003777 microtubule motor activity IBA 21873635
GO:0005515 protein binding IPI 17043677
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF3C: view
genes like me logo Genes that share phenotypes with KIF3C: view

Animal Models for KIF3C Gene

MGI Knock Outs for KIF3C:

Animal Model Products

CRISPR Products

miRNA for KIF3C Gene

miRTarBase miRNAs that target KIF3C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF3C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3C Gene

Localization for KIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF3C gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex TAS,IBA 21873635
GO:0005874 microtubule IBA 21873635
genes like me logo Genes that share ontologies with KIF3C: view

Pathways & Interactions for KIF3C Gene

genes like me logo Genes that share pathways with KIF3C: view

Gene Ontology (GO) - Biological Process for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0035735 intraciliary transport involved in cilium assembly TAS --
GO:0072384 organelle transport along microtubule IEA --
genes like me logo Genes that share ontologies with KIF3C: view

No data available for SIGNOR curated interactions for KIF3C Gene

Drugs & Compounds for KIF3C Gene

No Compound Related Data Available

Transcripts for KIF3C Gene

mRNA/cDNA for KIF3C Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF3C

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for KIF3C Gene

GeneLoc Exon Structure for
KIF3C

Expression for KIF3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF3C Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Anterior cingulate cortex (BA24) (x5.5).

Protein differential expression in normal tissues from HIPED for KIF3C Gene

This gene is overexpressed in Brain (38.1), Cervix (9.9), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF3C Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF3C

SOURCE GeneReport for Unigene cluster for KIF3C Gene:

Hs.21611

Evidence on tissue expression from TISSUES for KIF3C Gene

  • Nervous system(4.7)
  • Eye(2.7)
genes like me logo Genes that share expression patterns with KIF3C: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF3C Gene

Orthologs for KIF3C Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIF3C 30 31
  • 99.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIF3C 30 31
  • 92.81 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KIF3C 31
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia KIF3C 30 31
  • 91.28 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KIF3C 31
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kif3c 30
  • 89.79 (n)
Mouse
(Mus musculus)
Mammalia Kif3c 30 17 31
  • 89.49 (n)
OneToOne
Chicken
(Gallus gallus)
Aves KIF3C 30 31
  • 80.59 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kif3c 30
  • 73.7 (n)
Zebrafish
(Danio rerio)
Actinopterygii CABZ01076801.1 31
  • 75 (a)
OneToMany
kif3cb 30 31
  • 63.58 (n)
OneToMany
Dr.29546 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2897 30
Fruit Fly
(Drosophila melanogaster)
Insecta Klp68D 31 32
  • 41 (a)
OneToMany
Kif3C 32
  • 34 (a)
Worm
(Caenorhabditis elegans)
Secernentea osm-3 32
  • 37 (a)
klp-11 31 32
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToMany
Species where no ortholog for KIF3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KIF3C Gene

ENSEMBL:
Gene Tree for KIF3C (if available)
TreeFam:
Gene Tree for KIF3C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF3C: view image

Paralogs for KIF3C Gene

(14) SIMAP similar genes for KIF3C Gene using alignment to 6 proteins:

  • KIF3C_HUMAN
  • A2RU78_HUMAN
  • B7ZM25_HUMAN
  • F8WAR6_HUMAN
  • F8WER6_HUMAN
  • I6L9B9_HUMAN
genes like me logo Genes that share paralogs with KIF3C: view

Variants for KIF3C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF3C Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1465878 - p.Gln370Arg
rs772693472 - p.Arg571Gln

Additional dbSNP identifiers (rs#s) for KIF3C Gene

Structural Variations from Database of Genomic Variants (DGV) for KIF3C Gene

Variant ID Type Subtype PubMed ID
esv2659098 CNV deletion 23128226
esv33316 CNV loss 17666407
esv3554066 CNV deletion 23714750
nsv1123305 CNV deletion 24896259
nsv215114 CNV deletion 16902084

Variation tolerance for KIF3C Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF3C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3C Gene

Disorders for KIF3C Gene

Additional Disease Information for KIF3C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for KIF3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF3C Gene

Publications for KIF3C Gene

  1. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. (PMID: 9480755) Sardella M … Cabibbo A (Genomics 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C. (PMID: 9446808) Telford EA … Bonthron DT (Biochemical and biophysical research communications 1998) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. (PMID: 30948266) Lee SH … Mayr C (Molecular cell 2019) 3

Products for KIF3C Gene

Sources for KIF3C Gene