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Aliases for KIF3B Gene

Aliases for KIF3B Gene

  • Kinesin Family Member 3B 2 3 5
  • Microtubule Plus End-Directed Kinesin Motor 3B 3 4
  • HH0048 3 4
  • Kinesin-Like Protein KIF3B 3
  • KIAA0359 4
  • KLP-11 3
  • FLA8 3

External Ids for KIF3B Gene

Previous GeneCards Identifiers for KIF3B Gene

  • GC20P030653
  • GC20P031564
  • GC20P031610
  • GC20P030329
  • GC20P030865
  • GC20P027653

Summaries for KIF3B Gene

Entrez Gene Summary for KIF3B Gene

  • The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF3B Gene

KIF3B (Kinesin Family Member 3B) is a Protein Coding gene. Diseases associated with KIF3B include Tuberculous Peritonitis. Among its related pathways are Organelle biogenesis and maintenance and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF3C.

UniProtKB/Swiss-Prot for KIF3B Gene

  • Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).

Gene Wiki entry for KIF3B Gene

Additional gene information for KIF3B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3B Gene

Genomics for KIF3B Gene

GeneHancer (GH) Regulatory Elements for KIF3B Gene

Promoters and enhancers for KIF3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I032277 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 302 1.9 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 ZNF213 E2F8 KIF3B TSPY26P HCK GC20P032313 PIR40791
GH20I032006 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 -269.9 -269942 2.1 PKNOX1 ATF1 KLF17 SIN3A ETS1 ZNF23 GLIS2 ATF7 CREM REST RNA5SP481 KIF3B CCM2L COX4I2 GC20P031999
GH20I032461 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.4 +196.7 196679 24.7 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 NOL4L ENSG00000236772 ENSG00000233293 C20orf203 POFUT1 KIF3B EFCAB8 GC20M032477
GH20I032496 Enhancer 0.8 Ensembl ENCODE dbSUPER 5.8 +220.5 220484 2.7 GLIS1 NR2F2 CHD2 ENSG00000236772 KIF3B LOC101929698 GC20M032477 NOL4L
GH20I032456 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +179.7 179693 2.6 PKNOX1 KLF17 ZNF76 SIN3A BMI1 RAD21 ZNF335 GLIS2 ZNF366 ZNF143 ASXL1 PLAGL2 KIF3B ENSG00000236772 GC20M032477 NOL4L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIF3B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF3B gene promoter:

Genomic Locations for KIF3B Gene

Genomic Locations for KIF3B Gene
chr20:32,277,651-32,335,011
(GRCh38/hg38)
Size:
57,361 bases
Orientation:
Plus strand
chr20:30,865,454-30,922,814
(GRCh37/hg19)

Genomic View for KIF3B Gene

Genes around KIF3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3B Gene

Proteins for KIF3B Gene

  • Protein details for KIF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15066-KIF3B_HUMAN
    Recommended name:
    Kinesin-like protein KIF3B
    Protein Accession:
    O15066
    Secondary Accessions:
    • B2RMP4
    • B4DSR5
    • E1P5M5

    Protein attributes for KIF3B Gene

    Size:
    747 amino acids
    Molecular mass:
    85125 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 (By similarity). Interacts with the SMC3 subunit of the cohesin complex.
    SequenceCaution:
    • Sequence=BAA20815.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF3B Gene

    Alternative splice isoforms for KIF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF3B Gene

Post-translational modifications for KIF3B Gene

No Post-translational modifications

Other Protein References for KIF3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF3B Gene

Domains & Families for KIF3B Gene

Gene Families for KIF3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF3B Gene

Graphical View of Domain Structure for InterPro Entry

O15066

UniProtKB/Swiss-Prot:

KIF3B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3B: view

Function for KIF3B Gene

Molecular function for KIF3B Gene

GENATLAS Biochemistry:
kinesin family 3 member B,cDNA sequence,expressed in brain,>100kDa,homolog to murine kinesin KIF3B
UniProtKB/Swiss-Prot Function:
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).

Phenotypes From GWAS Catalog for KIF3B Gene

Gene Ontology (GO) - Molecular Function for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity TAS 9865700
GO:0005515 protein binding IPI 16298999
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed TAS 7559760
genes like me logo Genes that share ontologies with KIF3B: view
genes like me logo Genes that share phenotypes with KIF3B: view

Animal Models for KIF3B Gene

MGI Knock Outs for KIF3B:

Clone Products

  • Addgene plasmids for KIF3B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3B Gene

Localization for KIF3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3B Gene

Cytoplasm, cytoskeleton. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF3B gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 4
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoli (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA,NAS 16298999
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF3B: view

Pathways & Interactions for KIF3B Gene

genes like me logo Genes that share pathways with KIF3B: view

Gene Ontology (GO) - Biological Process for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007052 mitotic spindle organization TAS 16298999
GO:0007100 mitotic centrosome separation TAS 16298999
GO:0007368 determination of left/right symmetry TAS 9865700
genes like me logo Genes that share ontologies with KIF3B: view

No data available for SIGNOR curated interactions for KIF3B Gene

Drugs & Compounds for KIF3B Gene

(3) Drugs for KIF3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GSK-923295 Investigational Pharma CENP-E inhibitor,small-molecule, Kinesin protein inhibitors 0
MPI-0479605 Pharma Mps1 inhibitor,selective and ATP competitive 0
SB743921 Pharma Potent KSP inhibitor 0

(3) ApexBio Compounds for KIF3B Gene

Compound Action Cas Number
GSK-923295 CENP-E inhibitor,small-molecule 1088965-37-0
MPI-0479605 Mps1 inhibitor,selective and ATP competitive 1246529-32-7
SB743921 Potent KSP inhibitor 940929-33-9
genes like me logo Genes that share compounds with KIF3B: view

Drug Products

Transcripts for KIF3B Gene

mRNA/cDNA for KIF3B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(303) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF3B Gene

Kinesin family member 3B:
Representative Sequences:

Clone Products

  • Addgene plasmids for KIF3B

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3B Gene

No ASD Table

Relevant External Links for KIF3B Gene

GeneLoc Exon Structure for
KIF3B
ECgene alternative splicing isoforms for
KIF3B

Expression for KIF3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF3B Gene

This gene is overexpressed in Brain (29.3) and Fetal Brain (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF3B Gene



Protein tissue co-expression partners for KIF3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIF3B Gene:

KIF3B

SOURCE GeneReport for Unigene cluster for KIF3B Gene:

Hs.369670

Evidence on tissue expression from TISSUES for KIF3B Gene

  • Nervous system(4.8)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with KIF3B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF3B Gene

Orthologs for KIF3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF3B 33 34
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF3B 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF3B 33 34
  • 94.29 (n)
cow
(Bos Taurus)
Mammalia KIF3B 33 34
  • 91.21 (n)
rat
(Rattus norvegicus)
Mammalia Kif3b 33
  • 90.54 (n)
mouse
(Mus musculus)
Mammalia Kif3b 33 16 34
  • 90.14 (n)
chicken
(Gallus gallus)
Aves KIF3B 33 34
  • 80.29 (n)
lizard
(Anolis carolinensis)
Reptilia KIF3B 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3b 33
  • 75.27 (n)
Str.16554 33
zebrafish
(Danio rerio)
Actinopterygii kif3b 33 34
  • 72.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta Klp64D 35
  • 75 (a)
Klp68D 35 33 34
  • 56.67 (n)
Kif3C 35
  • 37 (a)
nod 35
  • 35 (a)
Kif19A 35
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010396 33
  • 57.04 (n)
worm
(Caenorhabditis elegans)
Secernentea klp-11 35 33 34
  • 58.35 (n)
osm-3 35
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP2 36
corn
(Zea mays)
Liliopsida Zm.13329 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 65 (a)
OneToMany
Species where no ortholog for KIF3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3B Gene

ENSEMBL:
Gene Tree for KIF3B (if available)
TreeFam:
Gene Tree for KIF3B (if available)

Paralogs for KIF3B Gene

Paralogs for KIF3B Gene

(12) SIMAP similar genes for KIF3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF3B: view

Variants for KIF3B Gene

Sequence variations from dbSNP and Humsavar for KIF3B Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000111811 -- 32,328,939(+) G/A intron_variant
rs1000133284 -- 32,279,755(+) T/C intron_variant
rs1000201323 -- 32,279,162(+) A/G intron_variant
rs1000213510 -- 32,325,223(+) C/G intron_variant
rs1000318471 -- 32,321,585(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF3B Gene

Variant ID Type Subtype PubMed ID
nsv956201 CNV deletion 24416366
nsv833954 CNV loss 17160897
nsv509764 CNV insertion 20534489
nsv179526 CNV deletion 16902084
nsv178620 CNV deletion 16902084
nsv1150511 CNV deletion 26484159
nsv1120393 CNV tandem duplication 24896259
esv3645663 CNV loss 21293372
esv3556998 CNV deletion 23714750
esv3059 CNV loss 18987735
esv2722342 CNV deletion 23290073
esv2670812 CNV deletion 23128226
esv2493207 CNV deletion 19546169
esv2404832 CNV deletion 18987734
esv1431260 CNV deletion 17803354
esv1361811 CNV insertion 17803354
esv1301631 CNV insertion 17803354
esv1171233 CNV insertion 17803354
esv1131334 CNV insertion 17803354
esv1121934 CNV insertion 17803354
dgv22e197 CNV deletion 19546169
dgv2239n106 CNV deletion 24896259

Variation tolerance for KIF3B Gene

Residual Variation Intolerance Score: 4.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3B Gene

Disorders for KIF3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
tuberculous peritonitis
  • peritonitis tuberculous
- elite association - COSMIC cancer census association via MalaCards
Search KIF3B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF3B

genes like me logo Genes that share disorders with KIF3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF3B Gene

Publications for KIF3B Gene

  1. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. (PMID: 9506951) Shimizu K … Takai Y (The Journal of biological chemistry 1998) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  3. Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. (PMID: 19635168) Aoki T … Satoh T (BMC cell biology 2009) 3 22 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. (PMID: 10548469) Whitehead JL … Burnside B (Experimental eye research 1999) 3 22 58

Products for KIF3B Gene

  • Addgene plasmids for KIF3B

Sources for KIF3B Gene

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