Aliases for KIF3A Gene

Aliases for KIF3A Gene

  • Kinesin Family Member 3A 2 3 5
  • Microtubule Plus End-Directed Kinesin Motor 3A 3 4
  • Kinesin-Like Protein KIF3A 3 4
  • Kinesin Family Protein 3A 2 3
  • KLP-20 2 3
  • FLA10 2 3
  • KIF3A 5
  • KIF3 4

External Ids for KIF3A Gene

Previous GeneCards Identifiers for KIF3A Gene

  • GC05M131554
  • GC05M132479
  • GC05M132064
  • GC05M132107
  • GC05M132059
  • GC05M127220

Summaries for KIF3A Gene

GeneCards Summary for KIF3A Gene

KIF3A (Kinesin Family Member 3A) is a Protein Coding gene. Diseases associated with KIF3A include Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease and Usher Syndrome, Type I. Among its related pathways are Organelle biogenesis and maintenance and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule binding. An important paralog of this gene is KIF3B.

UniProtKB/Swiss-Prot Summary for KIF3A Gene

  • Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.

Gene Wiki entry for KIF3A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF3A Gene

Genomics for KIF3A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIF3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF3A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF3A

Top Transcription factor binding sites by QIAGEN in the KIF3A gene promoter:
  • AhR
  • aMEF-2
  • AREB6
  • COMP1
  • HEN1
  • MEF-2A
  • Sox5
  • SRF
  • SRF (504 AA)
  • TBP

Genomic Locations for KIF3A Gene

Genomic Locations for KIF3A Gene
chr5:132,688,808-132,737,638
(GRCh38/hg38)
Size:
48,831 bases
Orientation:
Minus strand
chr5:132,028,320-132,073,330
(GRCh37/hg19)
Size:
45,011 bases
Orientation:
Minus strand

Genomic View for KIF3A Gene

Genes around KIF3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3A Gene

Proteins for KIF3A Gene

  • Protein details for KIF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y496-KIF3A_HUMAN
    Recommended name:
    Kinesin-like protein KIF3A
    Protein Accession:
    Q9Y496
    Secondary Accessions:
    • A8MSW9
    • Q59EN1
    • Q86XE9
    • Q9Y6V4

    Protein attributes for KIF3A Gene

    Size:
    699 amino acids
    Molecular mass:
    80041 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3B (By similarity). Interacts with PIFO (PubMed:20643351). Interacts with CLN3 (PubMed:22261744). Interacts with DCTN1 (By similarity). Interacts with FLCN (PubMed:27072130).
    SequenceCaution:
    • Sequence=AAC04475.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD93017.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for KIF3A Gene

Post-translational modifications for KIF3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF3A Gene

Domains & Families for KIF3A Gene

Gene Families for KIF3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIF3A Gene

Suggested Antigen Peptide Sequences for KIF3A Gene

GenScript: Design optimal peptide antigens:
  • Kinesin family member 3A, isoform CRA_a (D3DQ90_HUMAN)
  • Microtubule plus end-directed kinesin motor 3A (KIF3A_HUMAN)
  • Kinesin-like protein KIF3Abeta (Q2UVF2_HUMAN)
  • KIF3A protein (Q8IWH8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y496

UniProtKB/Swiss-Prot:

KIF3A_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3A: view

Function for KIF3A Gene

Molecular function for KIF3A Gene

UniProtKB/Swiss-Prot Function:
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
GENATLAS Biochemistry:
kinesin heavy chain member 3-like,mouse Kif3 homolog,putative microtubule associated motor protein,ATP dependent superfamily,N type,involved in anterograde transport of membranous organelles,distinct from synaptic vesicles

Phenotypes From GWAS Catalog for KIF3A Gene

Gene Ontology (GO) - Molecular Function for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 16298999
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF3A: view
genes like me logo Genes that share phenotypes with KIF3A: view

Animal Models for KIF3A Gene

MGI Knock Outs for KIF3A:

Animal Model Products

CRISPR Products

miRNA for KIF3A Gene

miRTarBase miRNAs that target KIF3A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF3A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3A Gene

Localization for KIF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3A Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the subdistal appendage region of the centriole. {ECO:0000269 PubMed:23386061}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF3A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 4
plasma membrane 3
endosome 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 16298999
GO:0005814 centriole IEA,IDA 23386061
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KIF3A: view

Pathways & Interactions for KIF3A Gene

genes like me logo Genes that share pathways with KIF3A: view

SIGNOR curated interactions for KIF3A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development IEA --
GO:0001947 heart looping IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006996 organelle organization TAS 1447303
genes like me logo Genes that share ontologies with KIF3A: view

Drugs & Compounds for KIF3A Gene

No Compound Related Data Available

Transcripts for KIF3A Gene

mRNA/cDNA for KIF3A Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF3A

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3A Gene

No ASD Table

Relevant External Links for KIF3A Gene

GeneLoc Exon Structure for
KIF3A

Expression for KIF3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF3A Gene

mRNA differential expression in normal tissues according to GTEx for KIF3A Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.4) and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for KIF3A Gene

This gene is overexpressed in Brain (19.7), Testis (8.0), Fetal Brain (8.0), and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF3A Gene



Protein tissue co-expression partners for KIF3A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF3A

SOURCE GeneReport for Unigene cluster for KIF3A Gene:

Hs.43670

Evidence on tissue expression from TISSUES for KIF3A Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Kidney(2.9)
  • Lung(2.3)
  • Heart(2.2)
  • Skin(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with KIF3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF3A Gene

Orthologs for KIF3A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIF3A 30 31
  • 99.14 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIF3A 30 31
  • 95.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KIF3A 30 31
  • 95.14 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KIF3A 31
  • 93 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kif3a 30
  • 87.32 (n)
Mouse
(Mus musculus)
Mammalia Kif3a 30 17 31
  • 86.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KIF3A 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIF3A 30 31
  • 81.69 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIF3A 31
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kif3a 30
  • 79.26 (n)
Str.3700 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.625 30
Zebrafish
(Danio rerio)
Actinopterygii KIF3A (1 of 2) 31
  • 92 (a)
OneToMany
kif3a 30 31
  • 77.14 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Klp64D 30 31 32
  • 59.13 (n)
OneToOne
Klp68D 32
  • 44 (a)
Kif3C 32
  • 39 (a)
nod 32
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002427 30
  • 57.15 (n)
Worm
(Caenorhabditis elegans)
Secernentea klp-20 30 31
  • 57.71 (n)
OneToOne
klp-11 32
  • 47 (a)
osm-3 32
  • 39 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 66 (a)
OneToOne
Species where no ortholog for KIF3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KIF3A Gene

ENSEMBL:
Gene Tree for KIF3A (if available)
TreeFam:
Gene Tree for KIF3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF3A: view image

Paralogs for KIF3A Gene

Pseudogenes.org Pseudogenes for KIF3A Gene

genes like me logo Genes that share paralogs with KIF3A: view

Variants for KIF3A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF3A Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs17854353 - p.Lys172Ile

Additional dbSNP identifiers (rs#s) for KIF3A Gene

Structural Variations from Database of Genomic Variants (DGV) for KIF3A Gene

Variant ID Type Subtype PubMed ID
dgv1646e212 CNV loss 25503493
esv3570417 CNV loss 25503493
nsv1114729 CNV deletion 24896259
nsv521072 CNV loss 19592680
nsv529021 CNV loss 19592680
nsv950393 CNV duplication 24416366

Variation tolerance for KIF3A Gene

Residual Variation Intolerance Score: 8.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.01; 93.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF3A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3A Gene

Disorders for KIF3A Gene

MalaCards: The human disease database

(24) MalaCards diseases for KIF3A Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search KIF3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF3A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KIF3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF3A Gene

Publications for KIF3A Gene

  1. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. (PMID: 23386061) Kodani A … Reiter JF (The EMBO journal 2013) 3 4
  2. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. (PMID: 22261744) Uusi-Rauva K … Jalanko A (Cellular and molecular life sciences : CMLS 2012) 3 4
  3. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PMID: 22197932) Paternoster L … EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (Nature genetics 2011) 3 41
  4. Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PMID: 20643351) Kinzel D … Lickert H (Developmental cell 2010) 3 4
  5. Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. (PMID: 20485362) Ridruechai C … Tokunaga K (Genes and immunity 2010) 3 41

Products for KIF3A Gene

  • Signalway Proteins for KIF3A

Sources for KIF3A Gene