Aliases for KIF2C Gene
External Ids for KIF2C Gene
Previous HGNC Symbols for KIF2C Gene
Previous GeneCards Identifiers for KIF2C Gene
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for KIF2C Gene
KIF2C (Kinesin Family Member 2C) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2A.
UniProtKB/Swiss-Prot for KIF2C Gene
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).