This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] See more...

Aliases for KIF2C Gene

Aliases for KIF2C Gene

  • Kinesin Family Member 2C 2 3 5
  • Mitotic Centromere-Associated Kinesin 3 4
  • Kinesin-Like Protein KIF2C 3 4
  • Kinesin-Like Protein 6 3 4
  • KNSL6 3 4
  • MCAK 3 4
  • Kinesin-Like 6 (Mitotic Centromere-Associated Kinesin) 2
  • Testis Tissue Sperm-Binding Protein Li 68n 3
  • CT139 3

External Ids for KIF2C Gene

Previous HGNC Symbols for KIF2C Gene

  • KNSL6

Previous GeneCards Identifiers for KIF2C Gene

  • GC01P044205
  • GC01P044635
  • GC01P044618
  • GC01P044874
  • GC01P044978
  • GC01P045208
  • GC01P043319

Summaries for KIF2C Gene

Entrez Gene Summary for KIF2C Gene

  • This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for KIF2C Gene

KIF2C (Kinesin Family Member 2C) is a Protein Coding gene. Diseases associated with KIF2C include Myocardial Infarction. Among its related pathways are Mitotic Metaphase and Anaphase and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2A.

UniProtKB/Swiss-Prot Summary for KIF2C Gene

  • In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).

Gene Wiki entry for KIF2C Gene

Additional gene information for KIF2C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF2C Gene

Genomics for KIF2C Gene

GeneHancer (GH) Regulatory Elements for KIF2C Gene

Promoters and enhancers for KIF2C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF2C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF2C

Top Transcription factor binding sites by QIAGEN in the KIF2C gene promoter:
  • AML1a
  • ATF-2
  • C/EBPalpha
  • E2F
  • E2F-1
  • Egr-4
  • ER-alpha
  • Spz1
  • TBP
  • YY1

Genomic Locations for KIF2C Gene

Genomic Locations for KIF2C Gene
chr1:44,739,712-44,767,767
(GRCh38/hg38)
Size:
28,056 bases
Orientation:
Plus strand
chr1:45,205,490-45,233,439
(GRCh37/hg19)
Size:
27,950 bases
Orientation:
Plus strand

Genomic View for KIF2C Gene

Genes around KIF2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2C Gene

Proteins for KIF2C Gene

  • Protein details for KIF2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99661-KIF2C_HUMAN
    Recommended name:
    Kinesin-like protein KIF2C
    Protein Accession:
    Q99661
    Secondary Accessions:
    • B3ITR9
    • Q5JR88
    • Q6ICU1
    • Q96C18
    • Q96HB8
    • Q9BWV8

    Protein attributes for KIF2C Gene

    Size:
    725 amino acids
    Molecular mass:
    81313 Da
    Quaternary structure:
    • Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.

    Three dimensional structures from OCA and Proteopedia for KIF2C Gene

    Alternative splice isoforms for KIF2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF2C Gene

Post-translational modifications for KIF2C Gene

  • Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
  • Ubiquitinated.
  • Ubiquitination at Lys38, Lys365, and Lys518
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIF2C Gene

Domains & Families for KIF2C Gene

Gene Families for KIF2C Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIF2C Gene

Suggested Antigen Peptide Sequences for KIF2C Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54088, highly similar to Kinesin-like protein KIF2C (B7Z6Q6_HUMAN)
  • cDNA FLJ53680, highly similar to Kinesin-like protein KIF2C (B7Z7M6_HUMAN)
  • Mitotic centromere-associated kinesin (KIF2C_HUMAN)
  • Kinesin family member 2C (Q5JR96_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99661

UniProtKB/Swiss-Prot:

KIF2C_HUMAN :
  • The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
Domain:
  • The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
genes like me logo Genes that share domains with KIF2C: view

Function for KIF2C Gene

Molecular function for KIF2C Gene

UniProtKB/Swiss-Prot Function:
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).

Phenotypes From GWAS Catalog for KIF2C Gene

Gene Ontology (GO) - Molecular Function for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IBA,IEA 21873635
GO:0005515 protein binding IPI 11092768
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with KIF2C: view
genes like me logo Genes that share phenotypes with KIF2C: view

Animal Models for KIF2C Gene

MGI Knock Outs for KIF2C:
  • Kif2c Kif2c<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF2C

CRISPR Products

miRNA for KIF2C Gene

miRTarBase miRNAs that target KIF2C

Clone Products

  • Addgene plasmids for KIF2C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF2C Gene

Localization for KIF2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2C Gene

Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2. {ECO:0000250 UniProtKB:P70096, ECO:0000269 PubMed:17485487, ECO:0000269 PubMed:21820309}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF2C gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Nucleoplasm (3)
  • Midbody (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA,IDA 14960279
GO:0000776 colocalizes_with kinetochore IEA,IDA 14960279
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with KIF2C: view

Pathways & Interactions for KIF2C Gene

genes like me logo Genes that share pathways with KIF2C: view

Pathways by source for KIF2C Gene

1 Qiagen pathway for KIF2C Gene
  • Reelin Pathway (Cajal-Retzius cells)

SIGNOR curated interactions for KIF2C Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement IEA,TAS --
GO:0007019 microtubule depolymerization TAS,IMP 26323690
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
genes like me logo Genes that share ontologies with KIF2C: view

Drugs & Compounds for KIF2C Gene

(6) Drugs for KIF2C Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
GSK-923295 Investigational Pharma CENP-E inhibitor,small-molecule, Kinesin protein inhibitors 0
MPI-0479605 Pharma Mps1 inhibitor,selective and ATP competitive 0
SB743921 Pharma Potent KSP inhibitor 0

(3) ApexBio Compounds for KIF2C Gene

Compound Action Cas Number
GSK-923295 CENP-E inhibitor,small-molecule 1088965-37-0
MPI-0479605 Mps1 inhibitor,selective and ATP competitive 1246529-32-7
SB743921 Potent KSP inhibitor 940929-33-9
genes like me logo Genes that share compounds with KIF2C: view

Drug Products

Transcripts for KIF2C Gene

mRNA/cDNA for KIF2C Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KIF2C

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - -
SP3:
SP4:
SP5: - -

ExUns: 21b ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for KIF2C Gene

GeneLoc Exon Structure for
KIF2C

Expression for KIF2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF2C Gene

mRNA differential expression in normal tissues according to GTEx for KIF2C Gene

This gene is overexpressed in Testis (x21.4).

Protein differential expression in normal tissues from HIPED for KIF2C Gene

This gene is overexpressed in Breast (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF2C Gene



Protein tissue co-expression partners for KIF2C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF2C

SOURCE GeneReport for Unigene cluster for KIF2C Gene:

Hs.720061

mRNA Expression by UniProt/SwissProt for KIF2C Gene:

Q99661-KIF2C_HUMAN
Tissue specificity: Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.

Evidence on tissue expression from TISSUES for KIF2C Gene

  • Blood(4.2)
  • Kidney(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with KIF2C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF2C Gene

Orthologs for KIF2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF2C 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIF2C 31 30
  • 91.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIF2C 31 30
  • 91.24 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kif2c 17 31 30
  • 87.2 (n)
rat
(Rattus norvegicus)
Mammalia Kif2c 30
  • 86.5 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF2C 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF2C 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF2C 31
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF2C 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif2c 30
  • 66 (n)
Str.4037 30
African clawed frog
(Xenopus laevis)
Amphibia kif2c-prov 30
zebrafish
(Danio rerio)
Actinopterygii kif2c 31
  • 51 (a)
OneToOne
Dr.13963 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5588 30
fruit fly
(Drosophila melanogaster)
Insecta Klp59C 31
  • 46 (a)
ManyToMany
Klp10A 31
  • 41 (a)
ManyToMany
Klp59D 31
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 31 30
  • 52.53 (n)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3329 30
wheat
(Triticum aestivum)
Liliopsida Ta.4571 30
corn
(Zea mays)
Liliopsida Zm.7332 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToMany
Species where no ortholog for KIF2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KIF2C Gene

ENSEMBL:
Gene Tree for KIF2C (if available)
TreeFam:
Gene Tree for KIF2C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF2C: view image

Paralogs for KIF2C Gene

(16) SIMAP similar genes for KIF2C Gene using alignment to 6 proteins:

  • KIF2C_HUMAN
  • B7Z6Q6_HUMAN
  • B7Z7M6_HUMAN
  • H0Y5Z9_HUMAN
  • Q5JR89_HUMAN
  • Q5JR91_HUMAN

Pseudogenes.org Pseudogenes for KIF2C Gene

genes like me logo Genes that share paralogs with KIF2C: view

Variants for KIF2C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF2C Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs4342887 - p.Ile449Leu

Additional dbSNP identifiers (rs#s) for KIF2C Gene

Structural Variations from Database of Genomic Variants (DGV) for KIF2C Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV loss 19166990
nsv476842 CNV novel sequence insertion 20440878
nsv546145 CNV loss 21841781
nsv998871 CNV loss 25217958

Variation tolerance for KIF2C Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.21; 81.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF2C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF2C Gene

Disorders for KIF2C Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF2C Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search KIF2C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF2C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIF2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF2C Gene

Publications for KIF2C Gene

  1. Cloning and expression of human mitotic centromere-associated kinesin gene. (PMID: 9434124) Kim IG … Kim YH (Biochimica et biophysica acta 1997) 2 3 4 23 54
  2. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K … Yao X (EMBO reports 2009) 3 4 23 54
  3. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. (PMID: 19060894) Bakhoum SF … Compton DA (Nature cell biology 2009) 3 4 23 54
  4. Aurora B regulates MCAK at the mitotic centromere. (PMID: 14960279) Andrews PD … Swedlow JR (Developmental cell 2004) 3 4 23 54
  5. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. (PMID: 23891108) Shrestha RL … Draviam VM (Current biology : CB 2013) 3 4 54

Products for KIF2C Gene