Aliases for KIF2C Gene
External Ids for KIF2C Gene
Previous HGNC Symbols for KIF2C Gene
Previous GeneCards Identifiers for KIF2C Gene
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for KIF2C Gene
KIF2C (Kinesin Family Member 2C) is a Protein Coding gene. Diseases associated with KIF2C include Myocardial Infarction. Among its related pathways are Mitotic Metaphase and Anaphase and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2A.
UniProtKB/Swiss-Prot Summary for KIF2C Gene
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).