This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled... See more...

Aliases for KIF27 Gene

Aliases for KIF27 Gene

  • Kinesin Family Member 27 2 3 5
  • Kinesin-Like Protein KIF27 3 4

External Ids for KIF27 Gene

Previous GeneCards Identifiers for KIF27 Gene

  • GC09M080006
  • GC09M081908
  • GC09M083681
  • GC09M085641
  • GC09M086451
  • GC09M056276
  • GC09M083836

Summaries for KIF27 Gene

Entrez Gene Summary for KIF27 Gene

  • This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

GeneCards Summary for KIF27 Gene

KIF27 (Kinesin Family Member 27) is a Protein Coding gene. Diseases associated with KIF27 include Acrocallosal Syndrome and Greig Cephalopolysyndactyly Syndrome. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF7.

UniProtKB/Swiss-Prot Summary for KIF27 Gene

Additional gene information for KIF27 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF27 Gene

Genomics for KIF27 Gene

GeneHancer (GH) Regulatory Elements for KIF27 Gene

Promoters and enhancers for KIF27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J083920 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 512.2 +0.3 323 2.5 HNRNPK ZBTB40 ZNF217 EP300 CTCF TCF12 NRF1 POLR2G SP1 PHF8 KIF27 LOC105376335 HNRNPK ENSG00000231616 MG828730-070
GH09J083922 Enhancer 0.4 ENCODE 500.7 -1.2 -1174 0.2 CTCF ZBTB33 SPI1 ZNF770 LOC105376335 KIF27 piR-50308-652 MG828730-070
GH09J082923 Enhancer 1.1 Ensembl ENCODE 25.9 +997.6 997566 2.2 EP300 ZSCAN5C ZNF639 ZNF10 ZIC2 ZNF623 ZNF423 ZNF510 TRIM28 CUX1 KIF27 piR-60146-193 lnc-FRMD3-5
GH09J083705 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.6 +214.3 214340 4.7 EP300 HNRNPK FOXK2 ZBTB40 ZNF217 CTCF TCF12 NRF1 POLR2G SP1 ENSG00000254473 LOC105376114 UBQLN1 KIF27 IDNK RF00017-7660 lnc-GKAP1-1
GH09J083620 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +298.0 297992 5.2 HNRNPK ZNF217 CTCF SIN3A POLR2G NCOR1 GTF2E2 PHF8 ZFX POLR2A IDNK ENSG00000254473 KIF27 UBQLN1 GKAP1 piR-44878-060 RF00017-7660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF27 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF27

Top Transcription factor binding sites by QIAGEN in the KIF27 gene promoter:
  • aMEF-2
  • FOXO1
  • FOXO1a
  • GATA-1
  • GATA-3
  • Ik-2
  • MEF-2A
  • Pax-6
  • SRY
  • YY1

Genomic Locations for KIF27 Gene

Genomic Locations for KIF27 Gene
chr9:83,834,099-83,921,467
(GRCh38/hg38)
Size:
87,369 bases
Orientation:
Minus strand
chr9:86,451,613-86,536,342
(GRCh37/hg19)
Size:
84,730 bases
Orientation:
Minus strand

Genomic View for KIF27 Gene

Genes around KIF27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF27 Gene

Proteins for KIF27 Gene

  • Protein details for KIF27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VH2-KIF27_HUMAN
    Recommended name:
    Kinesin-like protein KIF27
    Protein Accession:
    Q86VH2
    Secondary Accessions:
    • B2RTR8
    • Q5T6W0
    • Q86VH0
    • Q86VH1
    • Q9UF54

    Protein attributes for KIF27 Gene

    Size:
    1401 amino acids
    Molecular mass:
    160283 Da
    Quaternary structure:
    • Interacts with STK36.
    SequenceCaution:
    • Sequence=CAB63770.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF27 Gene

Post-translational modifications for KIF27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF27 Gene

Domains & Families for KIF27 Gene

Gene Families for KIF27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIF27 Gene

Suggested Antigen Peptide Sequences for KIF27 Gene

GenScript: Design optimal peptide antigens:
  • Kinesin family member 27 (E0ZS58_HUMAN)
  • Kinesin-like protein KIF27 (KIF27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86VH2

UniProtKB/Swiss-Prot:

KIF27_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
genes like me logo Genes that share domains with KIF27: view

Function for KIF27 Gene

Molecular function for KIF27 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in motile ciliogenesis.

Phenotypes From GWAS Catalog for KIF27 Gene

Gene Ontology (GO) - Molecular Function for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IBA 21873635
GO:0016887 ATPase activity IBA 21873635
genes like me logo Genes that share ontologies with KIF27: view
genes like me logo Genes that share phenotypes with KIF27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF27

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF27 Gene

Localization for KIF27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF27 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Localizes to centrioles and basal bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF27 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
extracellular 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA 21873635
GO:0005874 microtubule IBA 21873635
genes like me logo Genes that share ontologies with KIF27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF27 Gene

Pathways & Interactions for KIF27 Gene

genes like me logo Genes that share pathways with KIF27: view

Gene Ontology (GO) - Biological Process for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0007018 microtubule-based movement IBA 21873635
GO:0021591 ventricular system development IEA --
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly ISS --
genes like me logo Genes that share ontologies with KIF27: view

No data available for SIGNOR curated interactions for KIF27 Gene

Drugs & Compounds for KIF27 Gene

No Compound Related Data Available

Transcripts for KIF27 Gene

mRNA/cDNA for KIF27 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF27 Gene

No ASD Table

Relevant External Links for KIF27 Gene

GeneLoc Exon Structure for
KIF27

Expression for KIF27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF27 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for KIF27 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (46.3) and Brain (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF27 Gene



Protein tissue co-expression partners for KIF27 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF27

SOURCE GeneReport for Unigene cluster for KIF27 Gene:

Hs.697514

mRNA Expression by UniProt/SwissProt for KIF27 Gene:

Q86VH2-KIF27_HUMAN
Tissue specificity: Testis, pancreatic islet, germ cell tumors and Jurkat T-cells.

Evidence on tissue expression from TISSUES for KIF27 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with KIF27: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF27 Gene

Orthologs for KIF27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF27 31 30
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIF27 31 30
  • 90.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIF27 31 30
  • 88.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kif27 17 31 30
  • 81.31 (n)
rat
(Rattus norvegicus)
Mammalia Kif27 30
  • 80.66 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF27 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF27 31
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF27 31 30
  • 68.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF27 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif27 30
  • 61.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN8 31
  • 20 (a)
OneToMany
Species where no ortholog for KIF27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIF27 Gene

ENSEMBL:
Gene Tree for KIF27 (if available)
TreeFam:
Gene Tree for KIF27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF27: view image

Paralogs for KIF27 Gene

Pseudogenes.org Pseudogenes for KIF27 Gene

genes like me logo Genes that share paralogs with KIF27: view

Variants for KIF27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF27 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs12001918 Benign: not specified. - 83,903,881(-) T/Cp.Ile213Val MISSENSE_VARIANT,INTRON_VARIANT
rs13289566 Benign: not specified 83,889,090(-) C/T MISSENSE_VARIANT
rs295274 Benign: not specified 83,853,800(-) A/T SYNONYMOUS_VARIANT
rs55654273 Benign: not specified. - 83,859,200(-) T/Cp.Asn1036Asp MISSENSE_VARIANT,INTRON_VARIANT
rs58077086 Benign: not specified 83,850,216(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for KIF27 Gene

Structural Variations from Database of Genomic Variants (DGV) for KIF27 Gene

Variant ID Type Subtype PubMed ID
esv1179518 CNV insertion 17803354
esv2738669 CNV deletion 23290073
esv2759701 CNV gain 17122850
esv2761538 CNV gain 21179565
esv3393363 CNV duplication 20981092
esv3451136 CNV duplication 20981092
esv3620906 CNV gain 21293372
esv3620907 CNV gain 21293372
esv3620908 CNV gain 21293372
nsv1161879 OTHER complex 26073780
nsv436717 OTHER inversion 17901297
nsv438108 CNV loss 16468122
nsv442559 CNV gain 18776908
nsv469859 CNV gain 16826518
nsv6590 CNV deletion 18451855
nsv6591 CNV insertion 18451855
nsv831644 CNV gain 17160897
nsv8540 CNV gain 18304495
nsv8541 CNV gain 18304495
nsv972407 CNV duplication 23825009
nsv972767 CNV duplication 23825009
nsv982312 CNV duplication 23825009

Variation tolerance for KIF27 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.12; 93.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF27 Gene

Disorders for KIF27 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KIF27 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acrocallosal syndrome
  • acls
greig cephalopolysyndactyly syndrome
  • gcps
carpenter syndrome 1
  • crpt1
tukel syndrome
  • fibrosis of extraocular muscles, congenital, with ulnar hand anomalies
primary ciliary dyskinesia
  • pcd
- elite association - COSMIC cancer census association via MalaCards
Search KIF27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF27

genes like me logo Genes that share disorders with KIF27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF27 Gene

Publications for KIF27 Gene

  1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PMID: 12783626) Oduru S … Williams SC (BMC genomics 2003) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations. (PMID: 28378594) Sala S … Ampe C (Journal of proteome research 2017) 3 54
  4. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for KIF27 Gene

Sources for KIF27 Gene