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Aliases for KIF27 Gene

Aliases for KIF27 Gene

  • Kinesin Family Member 27 2 3 5

External Ids for KIF27 Gene

Previous GeneCards Identifiers for KIF27 Gene

  • GC09M080006
  • GC09M081908
  • GC09M083681
  • GC09M085641
  • GC09M086451
  • GC09M056276

Summaries for KIF27 Gene

Entrez Gene Summary for KIF27 Gene

  • This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

GeneCards Summary for KIF27 Gene

KIF27 (Kinesin Family Member 27) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF7.

UniProtKB/Swiss-Prot for KIF27 Gene

  • Plays an essential role in motile ciliogenesis.

Additional gene information for KIF27 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF27 Gene

Genomics for KIF27 Gene

GeneHancer (GH) Regulatory Elements for KIF27 Gene

Promoters and enhancers for KIF27 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I083920 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 240 2.1 HDGF SMAD1 ARNT ARID4B SIN3A YY1 ZNF207 DEK SP3 SP5 LOC105376335 KIF27 ENSG00000231616
GH09I083922 Enhancer 0.4 ENCODE 550.8 -1.2 -1174 0.2 CTCF ZBTB33 SPI1 LOC105376335 KIF27 C9orf64
GH09I083977 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 37 -58.6 -58590 5.5 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B IRF4 HNRNPK RMI1 KIF27 C9orf64 LOC105376116 IDNK GKAP1 ENSG00000235298
GH09I083620 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.1 +298.0 298049 5.3 HDGF FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B SP3 SP5 IDNK LOC105376114 KIF27 UBQLN1 GKAP1 GC09M083666
GH09I083705 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.6 +214.0 213984 3.9 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LOC105376114 UBQLN1 HNRNPK KIF27 IDNK GC09M083666
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIF27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF27 gene promoter:

Genomic Locations for KIF27 Gene

Genomic Locations for KIF27 Gene
84,770 bases
Minus strand

Genomic View for KIF27 Gene

Genes around KIF27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF27 Gene

Proteins for KIF27 Gene

  • Protein details for KIF27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF27
    Protein Accession:
    Secondary Accessions:
    • B2RTR8
    • Q5T6W0
    • Q86VH0
    • Q86VH1
    • Q9UF54

    Protein attributes for KIF27 Gene

    1401 amino acids
    Molecular mass:
    160283 Da
    Quaternary structure:
    • Interacts with STK36.
    • Sequence=CAB63770.1; Type=Frameshift; Positions=728; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF27 Gene


neXtProt entry for KIF27 Gene

Post-translational modifications for KIF27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF27 Gene

Domains & Families for KIF27 Gene

Gene Families for KIF27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
genes like me logo Genes that share domains with KIF27: view

Function for KIF27 Gene

Molecular function for KIF27 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in motile ciliogenesis.

Gene Ontology (GO) - Molecular Function for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with KIF27: view
genes like me logo Genes that share phenotypes with KIF27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF27

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF27 Gene

Localization for KIF27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF27 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Localizes to centrioles and basal bodies. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF27 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
genes like me logo Genes that share ontologies with KIF27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF27 Gene

Pathways & Interactions for KIF27 Gene

genes like me logo Genes that share pathways with KIF27: view

Gene Ontology (GO) - Biological Process for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly ISS --
genes like me logo Genes that share ontologies with KIF27: view

No data available for SIGNOR curated interactions for KIF27 Gene

Drugs & Compounds for KIF27 Gene

No Compound Related Data Available

Transcripts for KIF27 Gene

Unigene Clusters for KIF27 Gene

Kinesin family member 27:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF27 Gene

No ASD Table

Relevant External Links for KIF27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF27 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for KIF27 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (46.3) and Brain (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF27 Gene

Protein tissue co-expression partners for KIF27 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF27 Gene:


SOURCE GeneReport for Unigene cluster for KIF27 Gene:


mRNA Expression by UniProt/SwissProt for KIF27 Gene:

Tissue specificity: Testis, pancreatic islet, germ cell tumors and Jurkat T-cells.

Evidence on tissue expression from TISSUES for KIF27 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with KIF27: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF27 Gene

Orthologs for KIF27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIF27 33 34
  • 99.5 (n)
(Bos Taurus)
Mammalia KIF27 33 34
  • 90.18 (n)
(Canis familiaris)
Mammalia KIF27 33 34
  • 88.83 (n)
(Mus musculus)
Mammalia Kif27 33 16 34
  • 81.31 (n)
(Rattus norvegicus)
Mammalia Kif27 33
  • 80.66 (n)
(Monodelphis domestica)
Mammalia KIF27 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia KIF27 34
  • 45 (a)
(Gallus gallus)
Aves KIF27 33 34
  • 68.29 (n)
(Anolis carolinensis)
Reptilia KIF27 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif27 33
  • 61.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN8 34
  • 20 (a)
Species where no ortholog for KIF27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIF27 Gene

Gene Tree for KIF27 (if available)
Gene Tree for KIF27 (if available)

Paralogs for KIF27 Gene

Variants for KIF27 Gene

Sequence variations from dbSNP and Humsavar for KIF27 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs12001918 benign, not specified 83,903,881(-) T/C coding_sequence_variant, intron_variant, missense_variant
rs13289566 benign, not specified 83,889,090(-) C/T coding_sequence_variant, missense_variant
rs295274 benign, not specified 83,853,800(-) A/C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, synonymous_variant
rs55654273 benign, not specified 83,859,200(-) T/C coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs58077086 benign, not specified 83,850,216(-) T/C 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF27 Gene

Variant ID Type Subtype PubMed ID
esv1179518 CNV insertion 17803354
esv2738669 CNV deletion 23290073
esv2759701 CNV gain 17122850
esv2761538 CNV gain 21179565
esv3393363 CNV duplication 20981092
esv3451136 CNV duplication 20981092
esv3620906 CNV gain 21293372
esv3620907 CNV gain 21293372
esv3620908 CNV gain 21293372
nsv1161879 OTHER complex 26073780
nsv436717 OTHER inversion 17901297
nsv438108 CNV loss 16468122
nsv442559 CNV gain 18776908
nsv469859 CNV gain 16826518
nsv6590 CNV deletion 18451855
nsv6591 CNV insertion 18451855
nsv831644 CNV gain 17160897
nsv8540 CNV gain 18304495
nsv8541 CNV gain 18304495
nsv972407 CNV duplication 23825009
nsv972767 CNV duplication 23825009
nsv982312 CNV duplication 23825009

Variation tolerance for KIF27 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.12; 93.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF27 Gene

Disorders for KIF27 Gene

Additional Disease Information for KIF27

No disorders were found for KIF27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF27 Gene

Publications for KIF27 Gene

  1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PMID: 12783626) Oduru S … Williams SC (BMC genomics 2003) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 58
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for KIF27 Gene

Sources for KIF27 Gene

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