External Ids for KIF26B Gene
Previous GeneCards Identifiers for KIF26B Gene
The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
GeneCards Summary for KIF26B Gene
KIF26B (Kinesin Family Member 26B) is a Protein Coding gene. Diseases associated with KIF26B include Pontocerebellar Hypoplasia. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF26A.
UniProtKB/Swiss-Prot Summary for KIF26B Gene
Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).