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Aliases for KIF26A Gene

Aliases for KIF26A Gene

  • Kinesin Family Member 26A 2 3 5
  • KIAA1236 4

External Ids for KIF26A Gene

Previous GeneCards Identifiers for KIF26A Gene

  • GC14P098420
  • GC14P102595
  • GC14P103674
  • GC14P104605
  • GC14P084784

Summaries for KIF26A Gene

GeneCards Summary for KIF26A Gene

KIF26A (Kinesin Family Member 26A) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF26B.

UniProtKB/Swiss-Prot for KIF26A Gene

  • Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).

Additional gene information for KIF26A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF26A Gene

Genomics for KIF26A Gene

GeneHancer (GH) Regulatory Elements for KIF26A Gene

Promoters and enhancers for KIF26A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I104137 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.5 -451 2 CLOCK SIN3A ZNF2 ZNF48 GLIS2 ZNF143 KLF7 SP3 REST ZNF592 ENSG00000258748 GC14P104139 KIF26A LOC105370708 ENSG00000260285 CLBA1 LINC00638 ASPG
GH14I104139 Enhancer 0.8 ENCODE dbSUPER 550.8 +0.8 836 0.2 KLF1 SP3 SP2 KLF17 ZFHX2 PATZ1 EGR2 EZH2 ENSG00000258748 GC14P104139 KIF26A LOC105370708
GH14I104140 Enhancer 0.4 ENCODE dbSUPER 550.8 +1.2 1236 0.2 GC14P104139 KIF26A LOC105370708
GH14I104158 Enhancer 0.9 ENCODE 12.6 +20.3 20336 0.2 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ATF7 NCOA1 REST KIF26A C14orf180 KLC1 GC14P104161 GC14M104153
GH14I104222 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +85.9 85902 4.3 MEIS2 CTCF ESRRA KLF1 PKNOX1 ZNF223 KLF17 ZIC2 E2F1 ZFHX2 C14orf144 LOC105370693 KIF26A PPP1R13B TMEM179 GC14P104161 LOC105370694
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIF26A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF26A gene promoter:

Genomic Locations for KIF26A Gene

Genomic Locations for KIF26A Gene
chr14:104,138,723-104,180,898
(GRCh38/hg38)
Size:
42,176 bases
Orientation:
Plus strand
chr14:104,605,060-104,647,235
(GRCh37/hg19)

Genomic View for KIF26A Gene

Genes around KIF26A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF26A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF26A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF26A Gene

Proteins for KIF26A Gene

  • Protein details for KIF26A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULI4-KI26A_HUMAN
    Recommended name:
    Kinesin-like protein KIF26A
    Protein Accession:
    Q9ULI4
    Secondary Accessions:
    • Q8TAZ7
    • Q96GK3
    • Q9UFL3

    Protein attributes for KIF26A Gene

    Size:
    1882 amino acids
    Molecular mass:
    194590 Da
    Quaternary structure:
    • Interacts with GRB2 (via SH2 domain).
    SequenceCaution:
    • Sequence=AAH09415.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KIF26A Gene

Post-translational modifications for KIF26A Gene

No Post-translational modifications

Other Protein References for KIF26A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF26A Gene

Domains & Families for KIF26A Gene

Gene Families for KIF26A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF26A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULI4

UniProtKB/Swiss-Prot:

KI26A_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
genes like me logo Genes that share domains with KIF26A: view

Function for KIF26A Gene

Molecular function for KIF26A Gene

UniProtKB/Swiss-Prot Function:
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).

Phenotypes From GWAS Catalog for KIF26A Gene

Gene Ontology (GO) - Molecular Function for KIF26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 NOT microtubule motor activity IEA,ISS --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA,ISS --
GO:0016887 NOT ATPase activity ISS --
genes like me logo Genes that share ontologies with KIF26A: view
genes like me logo Genes that share phenotypes with KIF26A: view

Animal Models for KIF26A Gene

MGI Knock Outs for KIF26A:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF26A Gene

Localization for KIF26A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF26A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF26A gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF26A: view

Pathways & Interactions for KIF26A Gene

genes like me logo Genes that share pathways with KIF26A: view

Gene Ontology (GO) - Biological Process for KIF26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001560 regulation of cell growth by extracellular stimulus IEA,ISS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement IEA,TAS --
GO:0009968 negative regulation of signal transduction ISS,IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with KIF26A: view

No data available for SIGNOR curated interactions for KIF26A Gene

Drugs & Compounds for KIF26A Gene

No Compound Related Data Available

Transcripts for KIF26A Gene

mRNA/cDNA for KIF26A Gene

Unigene Clusters for KIF26A Gene

Kinesin family member 26A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF26A Gene

No ASD Table

Relevant External Links for KIF26A Gene

GeneLoc Exon Structure for
KIF26A
ECgene alternative splicing isoforms for
KIF26A

Expression for KIF26A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF26A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF26A Gene

This gene is overexpressed in Pancreas (57.4) and Bone marrow mesenchymal stem cell (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF26A Gene



Protein tissue co-expression partners for KIF26A Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF26A Gene:

KIF26A

SOURCE GeneReport for Unigene cluster for KIF26A Gene:

Hs.134970

Evidence on tissue expression from TISSUES for KIF26A Gene

  • Nervous system(4.1)
  • Muscle(4)
genes like me logo Genes that share expression patterns with KIF26A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF26A Gene

Orthologs for KIF26A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF26A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF26A 33 34
  • 98.1 (n)
cow
(Bos Taurus)
Mammalia KIF26A 33 34
  • 83.67 (n)
dog
(Canis familiaris)
Mammalia KIF26A 33 34
  • 83.37 (n)
mouse
(Mus musculus)
Mammalia Kif26a 33 16 34
  • 79.02 (n)
rat
(Rattus norvegicus)
Mammalia Kif26a 33
  • 78.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF26A 34
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF26A 34
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF26A 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF26A 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kif26ab 34
  • 45 (a)
OneToMany
kif26aa 34
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14535 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-8 34
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY1 34
  • 21 (a)
OneToMany
Species where no ortholog for KIF26A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF26A Gene

ENSEMBL:
Gene Tree for KIF26A (if available)
TreeFam:
Gene Tree for KIF26A (if available)

Paralogs for KIF26A Gene

Paralogs for KIF26A Gene

(1) SIMAP similar genes for KIF26A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF26A: view

Variants for KIF26A Gene

Sequence variations from dbSNP and Humsavar for KIF26A Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000005181 -- 104,165,439(+) C/T intron_variant
rs1000051232 -- 104,160,951(+) C/T intron_variant
rs1000101761 -- 104,161,191(+) G/A intron_variant
rs1000105928 -- 104,155,896(+) C/T intron_variant
rs1000213623 -- 104,149,212(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF26A Gene

Variant ID Type Subtype PubMed ID
nsv952264 CNV deletion 24416366
nsv832884 CNV loss 17160897
nsv827072 CNV gain 20364138
nsv566030 CNV gain 21841781
nsv566029 CNV loss 21841781
nsv519605 CNV loss 19592680
nsv509553 CNV insertion 20534489
nsv470674 CNV loss 18288195
nsv1115469 CNV duplication 24896259
nsv1108922 CNV deletion 24896259
nsv1054574 CNV loss 25217958
nsv1050479 CNV gain 25217958
esv6361 CNV loss 19470904
esv3635618 CNV gain 21293372
esv3397925 CNV duplication 20981092
esv2749190 CNV deletion 23290073
esv2670922 CNV deletion 23128226
esv2490382 CNV insertion 19546169
esv1239775 CNV insertion 17803354

Variation tolerance for KIF26A Gene

Gene Damage Index Score: 5.54; 72.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF26A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF26A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF26A Gene

Disorders for KIF26A Gene

Additional Disease Information for KIF26A

No disorders were found for KIF26A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF26A Gene

Publications for KIF26A Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H … Hirokawa N (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3 58

Products for KIF26A Gene

Sources for KIF26A Gene

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