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Aliases for KIF25 Gene

Aliases for KIF25 Gene

  • Kinesin Family Member 25 2 3 5
  • Kinesin-Like Protein 3 3 4
  • Kinesin-Like 3 2 3
  • KNSL3 3 4
  • Kinesin-Like Protein KIF25 3

External Ids for KIF25 Gene

Previous HGNC Symbols for KIF25 Gene

  • KNSL3

Previous GeneCards Identifiers for KIF25 Gene

  • GC06P168140
  • GC06P168176
  • GC06P168177
  • GC06P168237
  • GC06P168161
  • GC06P168418
  • GC06P165847

Summaries for KIF25 Gene

Entrez Gene Summary for KIF25 Gene

  • The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF25 Gene

KIF25 (Kinesin Family Member 25) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC3.

UniProtKB/Swiss-Prot for KIF25 Gene

  • Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).

Additional gene information for KIF25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF25 Gene

Genomics for KIF25 Gene

GeneHancer (GH) Regulatory Elements for KIF25 Gene

Promoters and enhancers for KIF25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J167997 Enhancer 0.4 ENCODE 650.7 +0.8 765 0.2 USF1 CHD2 KIF25-AS1 KIF25
GH06J167996 Enhancer 0.2 ENCODE 657.9 +0.3 257 0.3 KIF25-AS1 KIF25
GH06J168030 Enhancer 0.8 Ensembl ENCODE 18.5 +35.9 35926 3 ZNF189 ZNF398 ZBTB40 TEAD3 FOSL1 CREB1 PRDM10 FOS PRDM4 WT1 KIF25-AS1 KIF25 FRMD1 LOC105378135
GH06J167931 Enhancer 1.1 Ensembl ENCODE 10.8 -63.0 -62954 3.4 FOXA2 MLX ARID4B DMAP1 YY1 ATF7 NFKBIZ RXRA MIER2 REST KIF25 KIF25-AS1 AFDN HGC6.3 PIR39756
GH06J167963 Enhancer 0.9 ENCODE 11.5 -31.5 -31522 3.2 FOXA2 MLX ARID4B ZNF48 YY1 SLC30A9 NFKBIZ RXRA REST PPARG KIF25-AS1 KIF25 FRMD1 AFDN HGC6.3 PIR39756
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KIF25 Gene

Genomic Locations for KIF25 Gene
chr6:167,996,241-168,045,089
(GRCh38/hg38)
Size:
48,849 bases
Orientation:
Plus strand
chr6:168,396,921-168,445,769
(GRCh37/hg19)
Size:
48,849 bases
Orientation:
Plus strand

Genomic View for KIF25 Gene

Genes around KIF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF25 Gene

Proteins for KIF25 Gene

  • Protein details for KIF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIL4-KIF25_HUMAN
    Recommended name:
    Kinesin-like protein KIF25
    Protein Accession:
    Q9UIL4
    Secondary Accessions:
    • A8K0C3
    • O94775
    • Q5SZU9

    Protein attributes for KIF25 Gene

    Size:
    384 amino acids
    Molecular mass:
    40686 Da
    Quaternary structure:
    • Homotetramer.

    Alternative splice isoforms for KIF25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF25 Gene

Post-translational modifications for KIF25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF25 Gene

No data available for DME Specific Peptides for KIF25 Gene

Domains & Families for KIF25 Gene

Gene Families for KIF25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF25 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIL4

UniProtKB/Swiss-Prot:

KIF25_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF25: view

Function for KIF25 Gene

Molecular function for KIF25 Gene

UniProtKB/Swiss-Prot Function:
Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).

Phenotypes From GWAS Catalog for KIF25 Gene

Gene Ontology (GO) - Molecular Function for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed ISS --
genes like me logo Genes that share ontologies with KIF25: view
genes like me logo Genes that share phenotypes with KIF25: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF25 Gene

Localization for KIF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF25 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF25 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex TAS 9925916
genes like me logo Genes that share ontologies with KIF25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF25 Gene

Pathways & Interactions for KIF25 Gene

genes like me logo Genes that share pathways with KIF25: view

Gene Ontology (GO) - Biological Process for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation TAS 9925916
GO:0006996 organelle organization TAS 9925916
GO:0007018 microtubule-based movement IBA --
GO:0010507 negative regulation of autophagy IMP 22354037
GO:0046603 negative regulation of mitotic centrosome separation IDA 28263957
genes like me logo Genes that share ontologies with KIF25: view

No data available for SIGNOR curated interactions for KIF25 Gene

Drugs & Compounds for KIF25 Gene

No Compound Related Data Available

Transcripts for KIF25 Gene

mRNA/cDNA for KIF25 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF25 Gene

Kinesin family member 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF25 Gene

No ASD Table

Relevant External Links for KIF25 Gene

GeneLoc Exon Structure for
KIF25
ECgene alternative splicing isoforms for
KIF25

Expression for KIF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF25 Gene

mRNA differential expression in normal tissues according to GTEx for KIF25 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5) and Brain - Cerebellar Hemisphere (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of KIF25 Gene:

KIF25

SOURCE GeneReport for Unigene cluster for KIF25 Gene:

Hs.150013

Evidence on tissue expression from TISSUES for KIF25 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KIF25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF25 Gene

Orthologs for KIF25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF25 33
  • 97.74 (n)
cow
(Bos Taurus)
Mammalia KIF25 34 33
  • 68.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIF25 34 33
  • 67.64 (n)
OneToOne
chicken
(Gallus gallus)
Aves KIF25 34 33
  • 61.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF25 34
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-195e3.4 33
  • 57.39 (n)
KIF25 34
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ncd 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-15 34
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToOne
Species where no ortholog for KIF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF25 Gene

ENSEMBL:
Gene Tree for KIF25 (if available)
TreeFam:
Gene Tree for KIF25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF25: view image

Paralogs for KIF25 Gene

Paralogs for KIF25 Gene

(1) SIMAP similar genes for KIF25 Gene using alignment to 2 proteins:

  • KIF25_HUMAN
  • H0YAK6_HUMAN
genes like me logo Genes that share paralogs with KIF25: view

Variants for KIF25 Gene

Sequence variations from dbSNP and Humsavar for KIF25 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000026375 -- 168,040,419(+) A/G intron_variant
rs1000075927 -- 168,045,228(+) G/T downstream_transcript_variant
rs1000160743 -- 168,035,252(+) C/T intron_variant
rs1000233341 -- 168,030,192(+) G/A intron_variant
rs1000359225 -- 168,035,706(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF25 Gene

Variant ID Type Subtype PubMed ID
dgv11062n54 CNV gain 21841781
dgv11063n54 CNV gain 21841781
dgv11064n54 CNV gain 21841781
dgv1853e212 CNV gain 25503493
dgv217e55 CNV gain 17911159
dgv218e55 CNV gain 17911159
dgv27e196 CNV duplication 17116639
dgv6199n100 CNV gain 25217958
dgv61n64 CNV gain 17921354
dgv791n27 CNV gain 19166990
esv23528 CNV gain+loss 19812545
esv2422263 CNV duplication 17116639
esv2422479 CNV duplication 17116639
esv2446593 CNV insertion 19546169
esv2733270 CNV deletion 23290073
esv2733271 CNV deletion 23290073
esv2733272 CNV deletion 23290073
esv2759493 CNV gain 17122850
esv2761051 CNV gain 21179565
esv2763949 CNV gain 21179565
esv32818 CNV gain 17666407
esv3611678 CNV gain 21293372
esv3611679 CNV gain 21293372
esv3611681 CNV loss 21293372
esv3611682 CNV loss 21293372
nsv1030168 CNV gain 25217958
nsv1031275 CNV gain 25217958
nsv442020 CNV gain 18776908
nsv509173 CNV insertion 20534489
nsv515568 CNV gain+loss 19592680
nsv605445 CNV gain 21841781
nsv8004 CNV gain 18304495
nsv823930 CNV gain 20364138
nsv830865 CNV gain 17160897
nsv830866 CNV gain 17160897

Variation tolerance for KIF25 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF25 Gene

Disorders for KIF25 Gene

Additional Disease Information for KIF25

No disorders were found for KIF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF25 Gene

Publications for KIF25 Gene

  1. Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein. (PMID: 9925916) Okamoto S … Nakamura Y (Cytogenetics and cell genetics 1998) 3 4 22 58
  2. The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation. (PMID: 28263957) Decarreau J … Wordeman L (Nature cell biology 2017) 3 4 58
  3. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight NC … Tooze SA (The EMBO journal 2012) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization. (PMID: 9925910) Erdel M … Weiskirchen R (Cytogenetics and cell genetics 1998) 2 3 58

Products for KIF25 Gene

Sources for KIF25 Gene

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