Aliases for KIF25 Gene
External Ids for KIF25 Gene
Previous HGNC Symbols for KIF25 Gene
Previous GeneCards Identifiers for KIF25 Gene
The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]
GeneCards Summary for KIF25 Gene
KIF25 (Kinesin Family Member 25) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC3.
UniProtKB/Swiss-Prot for KIF25 Gene
Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).