The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multipl... See more...

Aliases for KIF23 Gene

Aliases for KIF23 Gene

  • Kinesin Family Member 23 2 3 5
  • MKLP1 2 3 4
  • Kinesin-Like 5 (Mitotic Kinesin-Like Protein 1) 2 3
  • Kinesin-Like Protein KIF23 3 4
  • MKLP-1 2 3
  • KNSL5 3 4
  • Mitotic Kinesin-Like Protein 1 4
  • Kinesin-Like Protein 5 4
  • KIF23 5
  • CHO1 3

External Ids for KIF23 Gene

Previous HGNC Symbols for KIF23 Gene

  • KNSL5

Previous GeneCards Identifiers for KIF23 Gene

  • GC15P062805
  • GC15P067285
  • GC15P067422
  • GC15P067493
  • GC15P069706
  • GC15P046539

Summaries for KIF23 Gene

Entrez Gene Summary for KIF23 Gene

  • The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CIViC Summary for KIF23 Gene

GeneCards Summary for KIF23 Gene

KIF23 (Kinesin Family Member 23) is a Protein Coding gene. Diseases associated with KIF23 include Anemia, Congenital Dyserythropoietic, Type Iii and Congenital Dyserythropoietic Anemia. Among its related pathways are Cell Cycle, Mitotic and Aurora B signaling. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF16B.

UniProtKB/Swiss-Prot Summary for KIF23 Gene

  • Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Gene Wiki entry for KIF23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF23 Gene

Genomics for KIF23 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIF23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J069412 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.4 355 4.4 SP1 MYC ZNF600 JUND ATF2 BRCA1 POLR2A ZIC2 MXD4 CEBPB KIF23 KIF23-AS1 PAQR5 RPLP1
GH15J069298 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 6.1 -114.6 -114646 2.8 ZNF10 ZIC2 BHLHE40 ZNF341 MAX SP2 USF2 ZSCAN5A ZBTB48 ZNF189 PAQR5 ENSG00000261634 HSALNG0106844 HSALNG0106848 PAQR5-DT KIF23 ANP32A ENSG00000259504 SNORA77-001
GH15J069410 Enhancer 0.9 Ensembl ENCODE 0.7 -3.5 -3520 0.9 ZNF654 JUND ATF2 BRCA1 CEBPB CTCF MAX CTBP1 RAD21 RFX5 ENSG00000207395 KIF23 KIF23-AS1 PAQR5
GH15J069394 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 0.4 -20.1 -20145 2.2 ZNF654 MYC ZNF600 MXD4 CTCF REST TRIM22 BHLHE40 TBP MNT ENSG00000259645 hsa-miR-5095-164 KIF23 KIF23-AS1 PAQR5
GH15J069411 Enhancer 0.4 Ensembl 0.7 -4.1 -4145 0.2 ATF2 SIN3A CTCF ZNF335 ENSG00000207395 KIF23 KIF23-AS1 PAQR5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF23 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF23

Top Transcription factor binding sites by QIAGEN in the KIF23 gene promoter:
  • CUTL1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for KIF23 Gene

Latest Assembly
chr15:69,414,246-69,448,427
(GRCh38/hg38)
Size:
34,182 bases
Orientation:
Plus strand

Previous Assembly
chr15:69,706,688-69,740,766
(GRCh37/hg19 by Entrez Gene)
Size:
34,079 bases
Orientation:
Plus strand

chr15:69,706,585-69,740,764
(GRCh37/hg19 by Ensembl)
Size:
34,180 bases
Orientation:
Plus strand

Genomic View for KIF23 Gene

Genes around KIF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF23 Gene

Proteins for KIF23 Gene

  • Protein details for KIF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02241-KIF23_HUMAN
    Recommended name:
    Kinesin-like protein KIF23
    Protein Accession:
    Q02241
    Secondary Accessions:
    • B4E1K0
    • Q8WVP0

    Protein attributes for KIF23 Gene

    Size:
    960 amino acids
    Molecular mass:
    110059 Da
    Quaternary structure:
    • Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.

    Three dimensional structures from OCA and Proteopedia for KIF23 Gene

    Alternative splice isoforms for KIF23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF23 Gene

Post-translational modifications for KIF23 Gene

  • Ubiquitinated. Deubiquitinated by USP8/UBPY.
  • Ubiquitination at Lys149, Lys384, Lys503, Lys523, Lys571, Lys577, Lys599, Lys624, Lys643, and Lys741
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIF23 Gene

Domains & Families for KIF23 Gene

Gene Families for KIF23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIF23 Gene

Suggested Antigen Peptide Sequences for KIF23 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58416, highly similar to Kinesin-like protein KIF23 (B4E1K0_HUMAN)
  • Mitotic kinesin-like protein 1 (KIF23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02241

UniProtKB/Swiss-Prot:

KIF23_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF23: view

Function for KIF23 Gene

Molecular function for KIF23 Gene

UniProtKB/Swiss-Prot Function:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Phenotypes From GWAS Catalog for KIF23 Gene

Gene Ontology (GO) - Molecular Function for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 11782313
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF23: view
genes like me logo Genes that share phenotypes with KIF23: view

Human Phenotype Ontology for KIF23 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for KIF23 Gene

miRTarBase miRNAs that target KIF23

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF23

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF23 Gene

Localization for KIF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF23 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF23 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
endosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Midbody ring (3)
  • Mitotic spindle (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 11782313
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20186884
GO:0005819 spindle TAS,IDA 15197175
genes like me logo Genes that share ontologies with KIF23: view

Pathways & Interactions for KIF23 Gene

genes like me logo Genes that share pathways with KIF23: view

Pathways by source for KIF23 Gene

1 KEGG pathway for KIF23 Gene
1 Qiagen pathway for KIF23 Gene
  • Mitotic Roles of Polo Like Kinases

Gene Ontology (GO) - Biological Process for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000022 mitotic spindle elongation TAS 1406973
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0000915 actomyosin contractile ring assembly IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement IEA,TAS --
genes like me logo Genes that share ontologies with KIF23: view

No data available for SIGNOR curated interactions for KIF23 Gene

Drugs & Compounds for KIF23 Gene

No Compound Related Data Available

Transcripts for KIF23 Gene

mRNA/cDNA for KIF23 Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF23

Alternative Splicing Database (ASD) splice patterns (SP) for KIF23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF23 Gene

GeneLoc Exon Structure for
KIF23

Expression for KIF23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF23 Gene

This gene is overexpressed in Testis (32.0), Lung (18.5), and Ovary (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF23 Gene



Protein tissue co-expression partners for KIF23 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF23

SOURCE GeneReport for Unigene cluster for KIF23 Gene:

Hs.270845

Evidence on tissue expression from TISSUES for KIF23 Gene

  • Blood(3)
  • Skin(3)
  • Heart(2.9)
  • Intestine(2.8)
  • Lung(2.8)
  • Liver(2.8)
  • Kidney(2.8)
  • Spleen(2.7)
  • Muscle(2.7)
  • Thyroid gland(2.7)
  • Eye(2.7)
  • Bone marrow(2.6)
  • Nervous system(2.6)
  • Lymph node(2.6)
  • Pancreas(2.3)
  • Adrenal gland(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF23 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • urinary
Regions:
Head and neck:
  • eye
  • head
  • mouth
Abdomen:
  • kidney
General:
  • blood
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with KIF23: view

Primer products for research

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF23 Gene

Orthologs for KIF23 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF23 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIF23 29 30
  • 99.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KIF23 29 30
  • 92.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIF23 29 30
  • 89.54 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KIF23 30
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kif23 29
  • 87.8 (n)
Mouse
(Mus musculus)
Mammalia Kif23 29 16 30
  • 86.94 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KIF23 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIF23 29 30
  • 76.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIF23 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kif23 29
  • 72.84 (n)
Str.2307 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.11537 29
Zebrafish
(Danio rerio)
Actinopterygii kif23 29 30
  • 68.26 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007706 29
  • 50.86 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta pav 29 30
  • 49.76 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea zen-4 29 30
  • 48.28 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9064 30
  • 43 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3303 29
Species where no ortholog for KIF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KIF23 Gene

ENSEMBL:
Gene Tree for KIF23 (if available)
TreeFam:
Gene Tree for KIF23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF23: view image
Alliance of Genome Resources:
Additional Orthologs for KIF23

Paralogs for KIF23 Gene

Pseudogenes.org Pseudogenes for KIF23 Gene

genes like me logo Genes that share paralogs with KIF23: view

Variants for KIF23 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF23 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs112860684 Benign: not provided 69,416,069(+) G/A
NM_138555.4(KIF23):c.81+6G>A
INTRON
rs137922672 Likely Benign: not provided 69,421,710(+) G/C
NM_138555.4(KIF23):c.274G>C (p.Val92Leu)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs150290143 Benign: not provided 69,421,666(+) A/G
NM_138555.4(KIF23):c.230A>G (p.Gln77Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs150307169 Benign: not provided 69,435,722(+) G/A
NM_138555.4(KIF23):c.1223G>A (p.Arg408Gln)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1595972244 Likely Benign: not provided 69,416,009(+) C/T
NM_138555.4(KIF23):c.27C>T (p.Pro9=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KIF23 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KIF23 Gene

Variant ID Type Subtype PubMed ID
esv2760037 CNV loss 17122850
nsv1585 CNV insertion 18451855
nsv520964 CNV gain 19592680

Variation tolerance for KIF23 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF23 Gene

Human Gene Mutation Database (HGMD)
KIF23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF23
Leiden Open Variation Database (LOVD)
KIF23

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF23 Gene

Disorders for KIF23 Gene

MalaCards: The human disease database

(8) MalaCards diseases for KIF23 Gene - From: CVR, ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search KIF23 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF23

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KIF23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF23 Gene

Publications for KIF23 Gene

  1. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PMID: 1406973) Nislow C … McIntosh JR (Nature 1992) 2 3 4
  2. Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23. (PMID: 23570799) Liljeholm M … Golovleva I (Blood 2013) 3 72
  3. Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. (PMID: 22522702) Makyio H … Nakayama K (The EMBO journal 2012) 3 4
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 40
  5. Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. (PMID: 19468300) Wolfe BA … Glotzer M (PLoS biology 2009) 3 4

Products for KIF23 Gene

Sources for KIF23 Gene