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The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multipl... See more...
Aliases for KIF23 Gene
Aliases for KIF23 Gene
External Ids for KIF23 Gene
- HGNC: 6392
- Entrez Gene: 9493
- Ensembl: ENSG00000137807
- OMIM: 605064
- UniProtKB: Q02241
Previous HGNC Symbols for KIF23 Gene
- KNSL5
Previous GeneCards Identifiers for KIF23 Gene
- GC15P062805
- GC15P067285
- GC15P067422
- GC15P067493
- GC15P069706
- GC15P046539
Summaries for KIF23 Gene
-
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for KIF23 Gene
KIF23 (Kinesin Family Member 23) is a Protein Coding gene. Diseases associated with KIF23 include Anemia, Congenital Dyserythropoietic, Type Iii and Congenital Dyserythropoietic Anemia. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Mitotic Telophase/Cytokinesis. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF20A.
UniProtKB/Swiss-Prot Summary for KIF23 Gene
-
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Additional gene information for KIF23 Gene
- HGNC(6392)
- Entrez Gene(9493)
- Ensembl(ENSG00000137807)
- OMIM(605064)
- UniProtKB(Q02241)
- Open Targets Platform(ENSG00000137807)
- Monarch Initiative
- Search for KIF23 at DataMed
- Search for KIF23 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF23 Gene
Genomics for KIF23 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KIF23 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KIF23 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF23
- Top Transcription factor binding sites by QIAGEN in the KIF23 gene promoter:
-
- CUTL1
- Oct-B1
- oct-B2
- oct-B3
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- POU2F2B
- POU2F2C
Genomic Locations for KIF23 Gene
Genomic Locations for KIF23 Gene
- chr15:69,414,246-69,448,427
- (GRCh38/hg38)
- Size:
- 34,182 bases
- Orientation:
- Plus strand
- chr15:69,706,585-69,740,764
- (GRCh37/hg19)
- Size:
- 34,180 bases
- Orientation:
- Plus strand
Genomic View for KIF23 Gene
Genes around KIF23 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q23 by HGNC
- 15q23 by Entrez Gene
- 15q23 by Ensembl
KIF23 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KIF23 Gene
Proteins for KIF23 Gene
-
Protein details for KIF23 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q02241-KIF23_HUMAN
- Recommended name:
- Kinesin-like protein KIF23
- Protein Accession:
- Q02241
- B4E1K0
- Q8WVP0
Protein attributes for KIF23 Gene
- Size:
- 960 amino acids
- Molecular mass:
- 110059 Da
- Quaternary structure:
-
- Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.
Protein Expression for KIF23 Gene
Post-translational modifications for KIF23 Gene
- Ubiquitinated. Deubiquitinated by USP8/UBPY.
-
Ubiquitination at Lys149, Lys384, Lys503, Lys523, Lys571, Lys577, Lys599, Lys624, Lys643, and Lys741
- NX_Q02241 (NX_Q02241-1)
- Modification sites at PhosphoSitePlus
Other Protein References for KIF23 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ KIF23 Polyclonal Antibody and Immunotag™ KIF23 Antibody
- Novus Biologicals Antibodies for KIF23
-
Abcam antibodies for KIF23
- Invitrogen Antibodies for KIF23 (AFLGC-KIF23)
-
Santa Cruz Biotechnology (SCBT) Antibodies for KIF23
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KIF23
- Origene Custom Protein Services for KIF23
No data available for DME Specific Peptides for KIF23 Gene
Domains & Families for KIF23 Gene
Gene Families for KIF23 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KIF23 Gene
- InterPro:
- Blocks:
-
- Kinesin, motor region
- ProtoNet:
Suggested Antigen Peptide Sequences for KIF23 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58416, highly similar to Kinesin-like protein KIF23 (B4E1K0_HUMAN)
- Mitotic kinesin-like protein 1 (KIF23_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q02241UniProtKB/Swiss-Prot:
KIF23_HUMAN :- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
- Family:
-
- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Function for KIF23 Gene
Molecular function for KIF23 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Phenotypes From GWAS Catalog for KIF23 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003774 | motor activity | IEA | -- |
| GO:0003777 | microtubule motor activity | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 11782313 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for KIF23 Gene
- GenomeRNAi human phenotypes for KIF23:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Strongly decreased CFP-tsO45G cell surface transport
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased cell number
- Decreased viability after Maraba virus infection
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased viability with MLN4924 (a NAE inhibitor)
- Cell division defect
- Mitotic spindle defects
- Decreased caspase 3/7 activity
- Multipolar spindles
- Decreased cell number, increased G2M DNA content, increased 8N DNA content
- Inhibition of centrosomal clustering
- Increased HPV16-GFP infection
- Two nuclei (binuclear), polylobed nuclei
- Increased cell number in G2M, increased number of polyploid cells, increased number of cells with high perimeter-to-area ratio nuclei
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KIF23 - Select products 50% OFF >
- * KIF23 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KIF23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KIF23
-
Santa Cruz Biotechnology (SCBT) CRISPR for KIF23
miRNA for KIF23 Gene
- miRTarBase miRNAs that target KIF23
-
- hsa-miR-424-5p (MIRT000657)
- hsa-miR-373-3p (MIRT002495)
- hsa-miR-106b-5p (MIRT020426)
- hsa-miR-215-5p (MIRT024496)
- hsa-miR-192-5p (MIRT026716)
- hsa-miR-16-5p (MIRT031809)
- hsa-miR-25-3p (MIRT050321)
- hsa-miR-20a-5p (MIRT440369)
- hsa-miR-5047 (MIRT506820)
- hsa-miR-1301-3p (MIRT506821)
- hsa-miR-7156-3p (MIRT506822)
- hsa-miR-4799-5p (MIRT506823)
- hsa-miR-340-5p (MIRT506824)
- hsa-miR-4524b-5p (MIRT506825)
- hsa-miR-4524a-5p (MIRT506826)
- hsa-miR-4660 (MIRT506827)
- hsa-miR-4509 (MIRT506828)
- hsa-miR-4744 (MIRT506829)
- hsa-miR-7157-5p (MIRT506830)
- hsa-miR-4310 (MIRT506831)
- hsa-miR-3163 (MIRT506832)
- hsa-miR-646 (MIRT506833)
- hsa-miR-519c-3p (MIRT506834)
- hsa-miR-519b-3p (MIRT506835)
- hsa-miR-519a-3p (MIRT506836)
- hsa-miR-3121-3p (MIRT506837)
- hsa-miR-4796-3p (MIRT506838)
- hsa-miR-548ah-5p (MIRT506839)
- hsa-miR-3609 (MIRT506840)
- hsa-miR-548ay-3p (MIRT506841)
- hsa-miR-548at-3p (MIRT506842)
- hsa-miR-548as-3p (MIRT506843)
- hsa-miR-548t-3p (MIRT506844)
- hsa-miR-548ap-3p (MIRT506845)
- hsa-miR-548aa (MIRT506846)
- hsa-miR-106a-5p (MIRT506847)
- hsa-miR-20b-5p (MIRT506848)
- hsa-miR-17-5p (MIRT506849)
- hsa-miR-526b-3p (MIRT506850)
- hsa-miR-519d-3p (MIRT506851)
- hsa-miR-93-5p (MIRT506852)
- hsa-miR-503-5p (MIRT506853)
- hsa-miR-15a-5p (MIRT506854)
- hsa-miR-195-5p (MIRT506855)
- hsa-miR-15b-5p (MIRT506856)
- hsa-miR-497-5p (MIRT506857)
- hsa-miR-6838-5p (MIRT506858)
- hsa-miR-103a-3p (MIRT506859)
- hsa-miR-107 (MIRT506860)
- hsa-miR-6874-3p (MIRT541185)
- hsa-miR-5584-3p (MIRT541186)
- hsa-miR-3168 (MIRT541187)
- hsa-miR-148b-5p (MIRT541188)
- hsa-miR-6818-5p (MIRT547732)
- hsa-miR-147a (MIRT547733)
- hsa-miR-183-3p (MIRT547734)
- hsa-miR-1257 (MIRT547735)
- hsa-miR-581 (MIRT547736)
- hsa-miR-6500-3p (MIRT547737)
- mmu-miR-5101 (MIRT582772)
- mmu-miR-340-5p (MIRT582773)
- mmu-miR-703 (MIRT582774)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KIF23
- Browse OriGene Inhibitory RNA Products For KIF23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF23
Clone Products
- Applied Biological Materials (abm): Clones for KIF23 - Select products 50% OFF >
- * KIF23 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KIF23
- Addgene plasmids for KIF23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KIF23
Cell Line Products
-
Horizon Cell Lines for KIF23
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF23 Gene
Localization for KIF23 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KIF23 Gene
- Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| plasma membrane | 2 |
| endosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
- Midbody ring (3)
- Mitotic spindle (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 11782313 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 20186884 |
Pathways & Interactions for KIF23 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Golgi-to-ER retrograde transport |
.52
|
|
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Vesicle-mediated transport | ||
| 4 | MicroRNAs in cancer | ||
| 5 | Mitotic Roles of Polo Like Kinases |
Mitotic Roles of Polo Like Kinases
-
|
|
Pathways by source for KIF23 Gene
1 BioSystems pathway for KIF23 Gene
1 KEGG pathway for KIF23 Gene
1 Qiagen pathway for KIF23 Gene
- Mitotic Roles of Polo Like Kinases
Interacting Proteins for KIF23 Gene
Selected Interacting proteins:
Q02241-KIF23_HUMAN
ENSP00000260363
for KIF23 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for KIF23
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000022 | mitotic spindle elongation | TAS | 1406973 |
| GO:0000281 | mitotic cytokinesis | IMP | 15843429 |
| GO:0000915 | actomyosin contractile ring assembly | IEA | -- |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | TAS | -- |
| GO:0007018 | microtubule-based movement | IEA,TAS | -- |
No data available for SIGNOR curated interactions for KIF23 Gene
Transcripts for KIF23 Gene
mRNA/cDNA for KIF23 Gene
- 5 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000260363 3723 nts (view in UCSC)
- ENST00000352331 3351 nts (view in UCSC)
- ENST00000395392 3357 nts (view in UCSC)
- ENST00000558303 1766 nts (view in UCSC)
- ENST00000558346 1656 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KIF23 - Select products 50% OFF >
- * KIF23 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KIF23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KIF23
-
Santa Cruz Biotechnology (SCBT) CRISPR for KIF23
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KIF23
- Browse OriGene Inhibitory RNA Products For KIF23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF23
Clone Products
- Applied Biological Materials (abm): Clones for KIF23 - Select products 50% OFF >
- * KIF23 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KIF23
- Addgene plasmids for KIF23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KIF23
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22 | ^ | 23 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: |
Relevant External Links for KIF23 Gene
- GeneLoc Exon Structure for
- KIF23
Expression for KIF23 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Bone (Muscoskeletal System)
This gene is overexpressed in Testis (32.0), Lung (18.5), and Ovary (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF23 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF23
SOURCE GeneReport for Unigene cluster for KIF23 Gene:
Hs.270845Evidence on tissue expression from TISSUES for KIF23 Gene
- Blood(3.1)
- Skin(3.1)
- Heart(3)
- Intestine(2.9)
- Lung(2.9)
- Liver(2.9)
- Kidney(2.9)
- Muscle(2.8)
- Spleen(2.8)
- Thyroid gland(2.8)
- Nervous system(2.7)
- Eye(2.7)
- Bone marrow(2.7)
- Lymph node(2.6)
- Pancreas(2.3)
- Adrenal gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF23 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- urinary
Regions:
Head and neck:
- eye
- head
- mouth
Abdomen:
- kidney
General:
- blood
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for KIF23
-
OriGene qPCR primer pairs and template standards for KIF23
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF23 Gene
Orthologs for KIF23 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KIF23 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KIF23 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KIF23 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KIF23 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Kif23 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Kif23 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | KIF23 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | KIF23 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KIF23 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kif23 30 |
|
||
| Str.2307 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11537 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | kif23 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007706 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | pav 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | zen-4 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9064 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3303 30 |
|
- Species where no ortholog for KIF23 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for KIF23 Gene
- ENSEMBL:
- Gene Tree for KIF23 (if available)
- TreeFam:
- Gene Tree for KIF23 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KIF23: view image
Paralogs for KIF23 Gene
Paralogs for KIF23 Gene
- KIF20A 5
- KIF13B 5
- KIF13A 5
- KIF5B 5
- KIF15 5
- KIF5C 5
- KIF5A 5
- KIF4A 5
- KIF4B 5
- KIF1A 5
- KIF1B 5
- KIF14 5
- KIF7 5
- KIF3C 5
- KIF16B 5
- KIF27 5
- CENPE 5
- KIF11 5
- KIF21A 5
- KIF3B 5
- KIF21B 5
- KIF1C 5
- KIF19 5
- KIF24 5
- KIF18A 5
- KIF17 5
- KIF3A 5
- KIF18B 5
- KIF22 5
- KIF9 5
- KIF26A 5
- KIF6 5
- KIF2A 5
- KIF2C 5
- KIFC2 5
- KIFC1 5
- KIF2B 5
- KIF26B 5
- KIFC3 5
- KIF25 5
- KIF12 5
(25) SIMAP similar genes for KIF23 Gene using alignment to 6 proteins:
- KIF23_HUMAN
- B4E1K0_HUMAN
- H0YKQ5_HUMAN
- H0YME6_HUMAN
- H0YMJ4_HUMAN
- H7BYN4_HUMAN
- KIF20A
- KIF20B
- KIF13B
- CENPE
- KIF18B
- KIF13A
- KIF5B-RET(NM_020975)_K23;R12
- KIF5B-RET(NM_020975)_K22;R12
- KIF5B-RET(NM_020975)_K16;R12
- KIF5B-RET(NM_020975)_K15;R12
- KIF5B-RET(NM_020630)_K24;R11
- KIF5B-RET(NM_020630)_K23;R12
- KIF5B-RET(NM_020630)_K22;R12
- KIF5B-RET(NM_020630)_K16;R12
- KIF5B-RET(NM_020630)_K15;R12
- KIF5B-ALK_K17;A20
- KIF5B-ALK
- KIF3A
- KIF1A
- KIF28P
- KIF5C
- KIFC3
- KIF6
- KIF27
- KIF5A
Pseudogenes.org Pseudogenes for KIF23 Gene
Variants for KIF23 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF23 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710300 | Benign: not provided | 69,421,666(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 717526 | Benign: not provided | 69,423,294(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 720141 | Benign: not provided | 69,417,444(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 726646 | Benign: not provided | 69,423,285(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 727951 | Likely Benign: not provided | 69,440,364(+) | T/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Residual Variation Intolerance Score:
27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.17;
61.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KIF23 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF23 Gene
Disorders for KIF23 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| anemia, congenital dyserythropoietic, type iii |
|
|
| congenital dyserythropoietic anemia |
|
|
| anemia, congenital dyserythropoietic, type iv |
|
|
| anemia, congenital dyserythropoietic, type ib |
|
|
| anemia, congenital dyserythropoietic, type ii |
|
|
Search KIF23 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KIF23
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KIF23 Gene
Publications for KIF23 Gene
- A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PMID: 1406973) Nislow C … McIntosh JR (Nature 1992) 2 3 4
- Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. (PMID: 22522702) Makyio H … Nakayama K (The EMBO journal 2012) 3 4
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41
- Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. (PMID: 19468300) Wolfe BA … Glotzer M (PLoS biology 2009) 3 4
- CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. (PMID: 19015243) Seguin L … Bertoglio J (Molecular and cellular biology 2009) 3 23
ExternalLinks
Products for KIF23 Gene
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Sources for KIF23 Gene
- (1) GeneCards
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