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The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
KIF23 (Kinesin Family Member 23) is a Protein Coding gene. Diseases associated with KIF23 include Anemia, Congenital Dyserythropoietic, Type Iii and Congenital Dyserythropoietic Anemia. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Mitotic Telophase/Cytokinesis. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF20A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003774 | motor activity | IEA | -- |
GO:0003777 | microtubule motor activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 11782313 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA,IDA | 11782313 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005813 | centrosome | IDA | 20186884 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Golgi-to-ER retrograde transport |
.52
|
|
2 | Cell Cycle, Mitotic |
.83
|
.60
|
3 | Vesicle-mediated transport | ||
4 | MicroRNAs in cancer | ||
5 | Mitotic Roles of Polo Like Kinases |
Mitotic Roles of Polo Like Kinases
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000022 | mitotic spindle elongation | TAS | 1406973 |
GO:0000281 | mitotic cytokinesis | IMP | 15843429 |
GO:0000915 | actomyosin contractile ring assembly | IEA | -- |
GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | TAS | -- |
GO:0007018 | microtubule-based movement | IEA,TAS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: |
ExUns: | 22 | ^ | 23 |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KIF23 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KIF23 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KIF23 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | KIF23 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Kif23 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Kif23 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | KIF23 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | KIF23 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | KIF23 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kif23 30 |
|
||
Str.2307 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.11537 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | kif23 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007706 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | pav 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | zen-4 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9064 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3303 30 |
|
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710300 | Benign: not provided | 69,421,666(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
717526 | Benign: not provided | 69,423,294(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
720141 | Benign: not provided | 69,417,444(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
726646 | Benign: not provided | 69,423,285(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
727951 | Likely Benign: not provided | 69,440,364(+) | T/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
anemia, congenital dyserythropoietic, type iii |
|
|
congenital dyserythropoietic anemia |
|
|
anemia, congenital dyserythropoietic, type iv |
|
|
anemia, congenital dyserythropoietic, type ib |
|
|
anemia, congenital dyserythropoietic, type ii |
|
|