Aliases for KIF23 Gene
Aliases for KIF23 Gene
External Ids for KIF23 Gene
- HGNC: 6392
- Entrez Gene: 9493
- Ensembl: ENSG00000137807
- OMIM: 605064
- UniProtKB: Q02241
Previous HGNC Symbols for KIF23 Gene
- KNSL5
Previous GeneCards Identifiers for KIF23 Gene
- GC15P062805
- GC15P067285
- GC15P067422
- GC15P067493
- GC15P069706
- GC15P046539
Summaries for KIF23 Gene
-
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for KIF23 Gene
KIF23 (Kinesin Family Member 23) is a Protein Coding gene. Diseases associated with KIF23 include Anemia, Congenital Dyserythropoietic, Type Iii and Congenital Dyserythropoietic Anemia. Among its related pathways are Cell Cycle, Mitotic and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF20B.
UniProtKB/Swiss-Prot for KIF23 Gene
-
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Additional gene information for KIF23 Gene
- Monarch Initiative
- Search for KIF23 at DataMed
- Search for KIF23 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF23 Gene
Genomics for KIF23 Gene
GeneHancer (GH) Regulatory Elements for KIF23 Gene
Promoters and enhancers for KIF23 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH15J069412 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 650.7 | +0.4 | 405 | 4.1 | PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 POLR2B | LOC145694 KIF23 ENSG00000259265 TLE3 PAQR5 GC15M069382 | |
| GH15J069410 | Enhancer | 0.8 | ENCODE | 0.7 | -3.8 | -3759 | 0.1 | HDGF PKNOX1 SIN3A BRCA1 RAD21 RFX5 ZNF335 SCRT2 ZNF143 RCOR1 | LOC145694 KIF23 ENSG00000207395 GC15M069382 | |
| GH15J069442 | Enhancer | 0.6 | ENCODE dbSUPER | 0.3 | +28.9 | 28870 | 0.7 | PKNOX1 ZNF362 SPI1 | GC15M069428 RPLP1 KIF23 | |
| GH15J069436 | Enhancer | 0.4 | ENCODE | 0.3 | +22.9 | 22872 | 1 | NFE2 MAFK | LOC100421811 GC15M069428 KIF23 | |
| GH15J069440 | Enhancer | 0.3 | Ensembl | 0.3 | +26.1 | 26055 | 0.6 | MAFG | GC15M069428 LOC100421811 KIF23 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KIF23 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KIF23 gene promoter:
-
- oct-B3
- POU2F2C
- CUTL1
- Oct-B1
- oct-B2
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- POU2F2B
Regulatory Element Products
Genomic Locations for KIF23 Gene
Genomic Locations for KIF23 Gene
- chr15:69,414,246-69,448,427
- (GRCh38/hg38)
- Size:
- 34,182 bases
- Orientation:
- Plus strand
- chr15:69,706,585-69,740,764
- (GRCh37/hg19)
- Size:
- 34,180 bases
- Orientation:
- Plus strand
Genomic View for KIF23 Gene
Genes around KIF23 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q23 by Entrez Gene
- 15q23 by HGNC
- 15q23 by Ensembl
KIF23 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KIF23 Gene
Proteins for KIF23 Gene
-
Protein details for KIF23 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q02241-KIF23_HUMAN
- Recommended name:
- Kinesin-like protein KIF23
- Protein Accession:
- Q02241
- B4E1K0
- Q8WVP0
Protein attributes for KIF23 Gene
- Size:
- 960 amino acids
- Molecular mass:
- 110059 Da
- Quaternary structure:
-
- Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.
Protein Expression for KIF23 Gene
Post-translational modifications for KIF23 Gene
- Ubiquitinated. Deubiquitinated by USP8/UBPY.
- Ubiquitination at Lys643, Lys624, Lys599, Lys577, isoforms=2, 3571, isoforms=2, 3523, isoforms=2, 3503, isoforms=2, 3384, and isoforms=2149
- Modification sites at PhosphoSitePlus
Other Protein References for KIF23 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KIF23
-
Abcam antibodies for KIF23
- Invitrogen Antibodies for KIF23 (AFLGC-KIF23)
- GeneTex KIF23 Antibody for KIF23
-
Santa Cruz Biotechnology (SCBT) Antibodies for KIF23
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KIF23
- Origene Custom Protein Services for KIF23
- Search GeneTex for Proteins for KIF23
Assay Products
No data available for DME Specific Peptides for KIF23 Gene
Domains & Families for KIF23 Gene
Gene Families for KIF23 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KIF23 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KIF23 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q02241UniProtKB/Swiss-Prot:
KIF23_HUMAN :- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
- Family:
-
- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Function for KIF23 Gene
Molecular function for KIF23 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003774 | motor activity | IEA | -- |
| GO:0003777 | microtubule motor activity | TAS,IBA | -- |
| GO:0005515 | protein binding | IPI | 11782313 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for KIF23 Gene
- GenomeRNAi human phenotypes for KIF23:
-
- Decreased HPV16-GFP infection
- Inhibition of centrosomal clustering
- Multipolar spindles
- G0/1 arrest
- Increased G1 DNA content
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability
- no effect
- Decreased cell number
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- Decreased viability after Maraba virus infection
- Decreased caspase 3/7 activity
- Increased cell number in S
- Mitotic spindle defects
- Increased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KIF23
-
CRISPR Products
-
OriGene CRISPR knockouts for KIF23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KIF23
- genomics-online: gRNA clones - Search results for 111 available KIF23 gene related products
- Overview of 111 available KIF23 gene related products
- Applied Biological Materials CRISPR for KIF23
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KIF23
- GenScript: Design CRISPR guide RNA sequences for KIF23
miRNA for KIF23 Gene
- miRTarBase miRNAs that target KIF23
-
- hsa-mir-424-5p (MIRT000657)
- hsa-mir-373-3p (MIRT002495)
- hsa-mir-106b-5p (MIRT020426)
- hsa-mir-215-5p (MIRT024496)
- hsa-mir-192-5p (MIRT026716)
- hsa-mir-16-5p (MIRT031809)
- hsa-mir-25-3p (MIRT050321)
- hsa-mir-20a-5p (MIRT440369)
- hsa-mir-5047 (MIRT506820)
- hsa-mir-1301-3p (MIRT506821)
- hsa-mir-7156-3p (MIRT506822)
- hsa-mir-4799-5p (MIRT506823)
- hsa-mir-340-5p (MIRT506824)
- hsa-mir-4524b-5p (MIRT506825)
- hsa-mir-4524a-5p (MIRT506826)
- hsa-mir-4660 (MIRT506827)
- hsa-mir-4509 (MIRT506828)
- hsa-mir-4744 (MIRT506829)
- hsa-mir-7157-5p (MIRT506830)
- hsa-mir-4310 (MIRT506831)
- hsa-mir-3163 (MIRT506832)
- hsa-mir-646 (MIRT506833)
- hsa-mir-519c-3p (MIRT506834)
- hsa-mir-519b-3p (MIRT506835)
- hsa-mir-519a-3p (MIRT506836)
- hsa-mir-3121-3p (MIRT506837)
- hsa-mir-4796-3p (MIRT506838)
- hsa-mir-548ah-5p (MIRT506839)
- hsa-mir-3609 (MIRT506840)
- hsa-mir-548ay-3p (MIRT506841)
- hsa-mir-548at-3p (MIRT506842)
- hsa-mir-548as-3p (MIRT506843)
- hsa-mir-548t-3p (MIRT506844)
- hsa-mir-548ap-3p (MIRT506845)
- hsa-mir-548aa (MIRT506846)
- hsa-mir-106a-5p (MIRT506847)
- hsa-mir-20b-5p (MIRT506848)
- hsa-mir-17-5p (MIRT506849)
- hsa-mir-526b-3p (MIRT506850)
- hsa-mir-519d-3p (MIRT506851)
- hsa-mir-93-5p (MIRT506852)
- hsa-mir-503-5p (MIRT506853)
- hsa-mir-15a-5p (MIRT506854)
- hsa-mir-195-5p (MIRT506855)
- hsa-mir-15b-5p (MIRT506856)
- hsa-mir-497-5p (MIRT506857)
- hsa-mir-6838-5p (MIRT506858)
- hsa-mir-103a-3p (MIRT506859)
- hsa-mir-107 (MIRT506860)
- hsa-mir-6874-3p (MIRT541185)
- hsa-mir-5584-3p (MIRT541186)
- hsa-mir-3168 (MIRT541187)
- hsa-mir-148b-5p (MIRT541188)
- hsa-mir-6818-5p (MIRT547732)
- hsa-mir-147a (MIRT547733)
- hsa-mir-183-3p (MIRT547734)
- hsa-mir-1257 (MIRT547735)
- hsa-mir-581 (MIRT547736)
- hsa-mir-6500-3p (MIRT547737)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KIF23
- Browse OriGene Inhibitory RNA Products For KIF23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF23
- genomics-online: shRNA clones - Search results for 111 available KIF23 gene related products
- Overview of 111 available KIF23 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KIF23
- Addgene plasmids for KIF23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KIF23
- Applied Biological Materials Clones for KIF23
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KIF23
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF23 Gene
Localization for KIF23 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KIF23 Gene
- Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 11782313 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for KIF23 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Golgi-to-ER retrograde transport |
.52
|
|
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Vesicle-mediated transport | ||
| 4 | MicroRNAs in cancer | ||
| 5 | Mitotic Roles of Polo Like Kinases | ||
Pathways by source for KIF23 Gene
1 BioSystems pathway for KIF23 Gene
1 KEGG pathway for KIF23 Gene
1 Qiagen pathway for KIF23 Gene
Interacting Proteins for KIF23 Gene
Selected Interacting proteins:
Q02241-KIF23_HUMAN
ENSP00000260363
for KIF23 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for KIF23
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000022 | mitotic spindle elongation | TAS | 1406973 |
| GO:0000281 | mitotic cytokinesis | IMP | 15843429 |
| GO:0000910 | cytokinesis | IEA | -- |
| GO:0000915 | actomyosin contractile ring assembly | IEA | -- |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | TAS | -- |
No data available for SIGNOR curated interactions for KIF23 Gene
Transcripts for KIF23 Gene
mRNA/cDNA for KIF23 Gene
- (12) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (2388) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000260363 3723 bps (uc002asb.5)
- ENST00000643966 3446 bps
- ENST00000395392 3357 bps (uc059ktq.1)
- ENST00000352331 3351 bps (uc059ktr.1)
- ENST00000561089 2743 bps (uc059kts.1)
Unigene Clusters for KIF23 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KIF23
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KIF23
- genomics-online: gRNA clones - Search results for 111 available KIF23 gene related products
- Overview of 111 available KIF23 gene related products
- Applied Biological Materials CRISPR for KIF23
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KIF23
- GenScript: Design CRISPR guide RNA sequences for KIF23
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KIF23
- Browse OriGene Inhibitory RNA Products For KIF23
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF23
- genomics-online: shRNA clones - Search results for 111 available KIF23 gene related products
- Overview of 111 available KIF23 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KIF23
- Addgene plasmids for KIF23
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KIF23
- Applied Biological Materials Clones for KIF23
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22 | ^ | 23 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: |
Expression for KIF23 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Bone (Muscoskeletal System)
This gene is overexpressed in Testis (32.0), Lung (18.5), and Ovary (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF23 Gene
NURSA nuclear receptor signaling pathways regulating expression of KIF23 Gene:
KIF23SOURCE GeneReport for Unigene cluster for KIF23 Gene:
Hs.270845Evidence on tissue expression from TISSUES for KIF23 Gene
- Blood(2.6)
- Spleen(2.4)
- Nervous system(2.3)
- Eye(2.2)
- Heart(2.2)
- Kidney(2.2)
- Lung(2.2)
- Thyroid gland(2.2)
- Adrenal gland(2.1)
- Bone marrow(2.1)
- Liver(2.1)
- Lymph node(2.1)
- Muscle(2.1)
- Intestine(2)
- Skin(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF23 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- urinary
Regions:
Head and neck:
- eye
- head
- mouth
Abdomen:
- kidney
General:
- blood
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for KIF23
-
OriGene qPCR primer pairs and template standards for KIF23
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF23 Gene
Orthologs for KIF23 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KIF23 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KIF23 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KIF23 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KIF23 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Kif23 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Kif23 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KIF23 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KIF23 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KIF23 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kif23 33 |
|
||
| Str.2307 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11537 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kif23 34 33 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007706 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | pav 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | zen-4 34 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9064 34 |
|
OneToOne | |
| Cin.3303 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3303 33 |
|
- Species where no ortholog for KIF23 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for KIF23 Gene
- ENSEMBL:
- Gene Tree for KIF23 (if available)
- TreeFam:
- Gene Tree for KIF23 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KIF23: view image
Paralogs for KIF23 Gene
Paralogs for KIF23 Gene
(25) SIMAP similar genes for KIF23 Gene using alignment to 6 proteins:
- KIF23_HUMAN
- B4E1K0_HUMAN
- H0YKQ5_HUMAN
- H0YME6_HUMAN
- H0YMJ4_HUMAN
- H7BYN4_HUMAN
- KIF20A
- KIF20B
- KIF13B
- CENPE
- KIF18B
- KIF13A
- KIF5B-RET(NM_020975)_K23;R12
- KIF5B-RET(NM_020975)_K22;R12
- KIF5B-RET(NM_020975)_K16;R12
- KIF5B-RET(NM_020975)_K15;R12
- KIF5B-RET(NM_020630)_K24;R11
- KIF5B-RET(NM_020630)_K23;R12
- KIF5B-RET(NM_020630)_K22;R12
- KIF5B-RET(NM_020630)_K16;R12
- KIF5B-RET(NM_020630)_K15;R12
- KIF5B-ALK_K17;A20
- KIF5B-ALK
- KIF3A
- KIF1A
- KIF28P
- KIF5C
- KIFC3
- KIF6
- KIF27
- KIF5A
Pseudogenes.org Pseudogenes for KIF23 Gene
Variants for KIF23 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs748016594 | likely-pathogenic, Microcephaly | 69,426,090(+) | T/A/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant | |
| rs1000013192 | -- | 69,444,534(+) | T/A | intron_variant | |
| rs1000072330 | -- | 69,436,980(+) | C/G | intron_variant | |
| rs1000218024 | -- | 69,430,067(+) | T/C | intron_variant | |
| rs1000284116 | -- | 69,430,466(+) | A/C | intron_variant |
Residual Variation Intolerance Score:
27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.17;
61.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KIF23 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF23 Gene
Disorders for KIF23 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| anemia, congenital dyserythropoietic, type iii |
|
|
| congenital dyserythropoietic anemia |
|
|
Search KIF23 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KIF23
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KIF23 Gene
Publications for KIF23 Gene
- A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PMID: 1406973) Nislow C … McIntosh JR (Nature 1992) 2 3 4 58
- Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. (PMID: 22522702) Makyio H … Nakayama K (The EMBO journal 2012) 3 4 58
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
- Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. (PMID: 19468300) Wolfe BA … Glotzer M (PLoS biology 2009) 3 4 58
- CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. (PMID: 19015243) Seguin L … Bertoglio J (Molecular and cellular biology 2009) 3 22 58
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