Aliases for KIF20A Gene

Aliases for KIF20A Gene

  • Kinesin Family Member 20A 2 3 5
  • RAB6 Interacting, Kinesin-Like (Rabkinesin6) 2 3
  • Rab6-Interacting Kinesin-Like Protein 3 4
  • Mitotic Kinesin-Like Protein 2 3 4
  • Kinesin-Like Protein KIF20A 3 4
  • Rabkinesin-6 3 4
  • RAB6KIFL 3 4
  • GG10_2 3 4
  • MKLP2 3 4
  • MKlp2 4

External Ids for KIF20A Gene

Previous HGNC Symbols for KIF20A Gene

  • RAB6KIFL

Previous GeneCards Identifiers for KIF20A Gene

  • GC05P137545
  • GC05P137591
  • GC05P137542
  • GC05P132705

Summaries for KIF20A Gene

GeneCards Summary for KIF20A Gene

KIF20A (Kinesin Family Member 20A) is a Protein Coding gene. Diseases associated with KIF20A include Familial Isolated Restrictive Cardiomyopathy and Charcot-Marie-Tooth Disease, Type 4C. Among its related pathways are Class I MHC mediated antigen processing and presentation and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ATPase activity. An important paralog of this gene is KIF23.

UniProtKB/Swiss-Prot Summary for KIF20A Gene

  • Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Gene Wiki entry for KIF20A Gene

Additional gene information for KIF20A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF20A Gene

Genomics for KIF20A Gene

GeneHancer (GH) Regulatory Elements for KIF20A Gene

Promoters and enhancers for KIF20A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF20A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF20A

Top Transcription factor binding sites by QIAGEN in the KIF20A gene promoter:
  • c-Ets-1
  • C/EBPbeta
  • CBF(2)
  • CBF-A
  • Ik-1
  • Lmo2
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • RelA

Genomic Locations for KIF20A Gene

Genomic Locations for KIF20A Gene
chr5:138,178,719-138,187,723
(GRCh38/hg38)
Size:
9,005 bases
Orientation:
Plus strand
chr5:137,514,408-137,523,404
(GRCh37/hg19)
Size:
8,997 bases
Orientation:
Plus strand

Genomic View for KIF20A Gene

Genes around KIF20A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF20A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF20A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF20A Gene

Proteins for KIF20A Gene

  • Protein details for KIF20A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95235-KI20A_HUMAN
    Recommended name:
    Kinesin-like protein KIF20A
    Protein Accession:
    O95235
    Secondary Accessions:
    • B4DL79
    • D3DQB6

    Protein attributes for KIF20A Gene

    Size:
    890 amino acids
    Molecular mass:
    100278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF20A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF20A Gene

Post-translational modifications for KIF20A Gene

  • Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
  • Ubiquitination at Lys108, Lys150, Lys175, Lys215, Lys242, and Lys425
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF20A Gene

Antibody Products

  • Abcam antibodies for KIF20A
  • Santa Cruz Biotechnology (SCBT) Antibodies for KIF20A

No data available for DME Specific Peptides for KIF20A Gene

Domains & Families for KIF20A Gene

Gene Families for KIF20A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIF20A Gene

Suggested Antigen Peptide Sequences for KIF20A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55710, highly similar to Kinesin family member 20A (B4DL79_HUMAN)
  • Rabkinesin-6 (KI20A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95235

UniProtKB/Swiss-Prot:

KI20A_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF20A: view

Function for KIF20A Gene

Molecular function for KIF20A Gene

UniProtKB/Swiss-Prot Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Phenotypes From GWAS Catalog for KIF20A Gene

Gene Ontology (GO) - Molecular Function for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with KIF20A: view
genes like me logo Genes that share phenotypes with KIF20A: view

Animal Models for KIF20A Gene

MGI Knock Outs for KIF20A:
  • Kif20a Kif20a<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF20A

CRISPR Products

miRNA for KIF20A Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF20A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF20A Gene

Localization for KIF20A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF20A Gene

Golgi apparatus. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF20A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
extracellular 4
golgi apparatus 4
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cleavage furrow (3)
  • Cytokinetic bridge (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle IDA,IEA 12939256
genes like me logo Genes that share ontologies with KIF20A: view

Pathways & Interactions for KIF20A Gene

genes like me logo Genes that share pathways with KIF20A: view

Gene Ontology (GO) - Biological Process for KIF20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP,IEA 15843429
GO:0001578 microtubule bundle formation IDA 12939256
GO:0007018 microtubule-based movement IEA,IBA 21873635
GO:0015031 protein transport IEA --
GO:0032465 regulation of cytokinesis IDA 12939256
genes like me logo Genes that share ontologies with KIF20A: view

No data available for SIGNOR curated interactions for KIF20A Gene

Drugs & Compounds for KIF20A Gene

(7) Drugs for KIF20A Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chenodeoxycholic acid Approved Pharma Antagonist, Full agonist, Agonist 41
Guanosine triphosphate Experimental Pharma 0
Cathartics Pharma 708
Gastrointestinal Agents Pharma 10480
Immunologic Factors Pharma 30591
genes like me logo Genes that share compounds with KIF20A: view

Transcripts for KIF20A Gene

mRNA/cDNA for KIF20A Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF20A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF20A Gene

No ASD Table

Relevant External Links for KIF20A Gene

GeneLoc Exon Structure for
KIF20A

Expression for KIF20A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF20A Gene

mRNA differential expression in normal tissues according to GTEx for KIF20A Gene

This gene is overexpressed in Testis (x5.1) and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for KIF20A Gene

This gene is overexpressed in Salivary gland (42.3), Testis (13.7), and Fetal heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF20A Gene



Protein tissue co-expression partners for KIF20A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF20A

SOURCE GeneReport for Unigene cluster for KIF20A Gene:

Hs.718626

Evidence on tissue expression from TISSUES for KIF20A Gene

  • Heart(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KIF20A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF20A Gene

Orthologs for KIF20A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF20A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF20A 31 30
  • 99.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIF20A 31 30
  • 90.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIF20A 31
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif20a 30
  • 85.74 (n)
mouse
(Mus musculus)
Mammalia Kif20a 17 31 30
  • 85.23 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF20A 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 10 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KIF20A 31 30
  • 69.68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF20A 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif20a 30
  • 63.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6107 30
zebrafish
(Danio rerio)
Actinopterygii LOC325449 30
  • 55.81 (n)
kif20a 31
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sub 31
  • 27 (a)
OneToMany
Species where no ortholog for KIF20A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF20A Gene

ENSEMBL:
Gene Tree for KIF20A (if available)
TreeFam:
Gene Tree for KIF20A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF20A: view image

Paralogs for KIF20A Gene

(6) SIMAP similar genes for KIF20A Gene using alignment to 5 proteins:

  • KI20A_HUMAN
  • B4DL79_HUMAN
  • D6R9E4_HUMAN
  • D6RBN1_HUMAN
  • H0YAC9_HUMAN
genes like me logo Genes that share paralogs with KIF20A: view

Variants for KIF20A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF20A Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
708339 Benign: not provided 138,181,443(+) G/A MISSENSE_VARIANT
715400 Benign: not provided 138,186,028(+) C/T SYNONYMOUS_VARIANT
739680 Likely Benign: not provided 138,182,959(+) C/T SYNONYMOUS_VARIANT
776591 Likely Benign: not provided 138,179,811(+) C/T MISSENSE_VARIANT
rs3172747 - p.Pro839Leu

Additional dbSNP identifiers (rs#s) for KIF20A Gene

Variation tolerance for KIF20A Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF20A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF20A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIF20A Gene

Disorders for KIF20A Gene

MalaCards: The human disease database

(5) MalaCards diseases for KIF20A Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
familial isolated restrictive cardiomyopathy
  • familial or idiopathic restrictive cardiomyopathy
charcot-marie-tooth disease, type 4c
  • cmt4c
microcephaly, autosomal dominant
  • autosomal dominant microcephaly
ehrlich tumor carcinoma
  • ehrlich's tumor
charcot-marie-tooth disease
  • peroneal muscular atrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KIF20A

genes like me logo Genes that share disorders with KIF20A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF20A Gene

Publications for KIF20A Gene

  1. cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene. (PMID: 10806357) Lai F … Le Beau MM (Gene 2000) 2 3 4 23 54
  2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets AJ … Pannekoek H (Blood 1999) 3 4 23 54
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C. (PMID: 12469216) Nagura M … Hayashi Y (International journal of molecular medicine 2003) 3 23 54

Products for KIF20A Gene

Sources for KIF20A Gene