Aliases for KIF19 Gene

Aliases for KIF19 Gene

  • Kinesin Family Member 19 2 3 5
  • Kinesin-Like Protein KIF19 3 4
  • KIF19A 2 3
  • FLJ37300 2
  • KIF19 5

External Ids for KIF19 Gene

Previous GeneCards Identifiers for KIF19 Gene

  • GC17P069834
  • GC17P072321

Summaries for KIF19 Gene

GeneCards Summary for KIF19 Gene

KIF19 (Kinesin Family Member 19) is a Protein Coding gene. Diseases associated with KIF19 include Orofaciodigital Syndrome I. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF26B.

UniProtKB/Swiss-Prot Summary for KIF19 Gene

  • Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF19 Gene

Genomics for KIF19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIF19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074324 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 250.7 -0.1 -109 0.6 SIN3A SMARCA5 HNRNPL EZH2 TCF12 BACH1 KDM1A HSALNG0118642 KIF19 LOC105371891 DNAI2
GH17J074326 Promoter 0.4 Ensembl 256 +0.5 491 0.2 NR2F2 KIF19 HSALNG0118642 LOC107985078 BTBD17
GH17J074813 Enhancer 0.5 FANTOM5 dbSUPER 4.7 +487.0 487020 0.4 ZIC2 GRIN2C FADS6 CD300E KIF19 KCTD2 RAB37 lnc-NAT9-2 lnc-SLC9A3R1-4 TMEM104
GH17J074192 Enhancer 1 FANTOM5 ENCODE 1.9 -132.7 -132699 1.4 CEBPA ZNF217 THAP11 MBD2 FOXA2 SAP130 RXRA HES1 CTBP1 SMARCA5 HSALNG0118632 KIF19 HSALNG0118631 RPL38 SDK2
GH17J074807 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 1.8 +482.4 482391 2.4 SPI1 RCOR1 CHD2 ZFHX2 lnc-NAT9-2 GRIN2C RAB37 FADS6 NAT9 TMEM104 CD300E KCTD2 KIF19 lnc-SLC9A3R1-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF19

Top Transcription factor binding sites by QIAGEN in the KIF19 gene promoter:
  • AML1a
  • AP-1
  • Bach2
  • c-Fos
  • c-Jun
  • FosB
  • FOXD1
  • Fra-1
  • Pax-5
  • RREB-1

Genomic Locations for KIF19 Gene

Latest Assembly
29,611 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
29,595 bases
Plus strand

(GRCh37/hg19 by Ensembl)
29,611 bases
Plus strand

Genomic View for KIF19 Gene

Genes around KIF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF19 Gene

Proteins for KIF19 Gene

  • Protein details for KIF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF19
    Protein Accession:
    Secondary Accessions:
    • A6NLG2
    • B7ZKR1
    • Q52M87
    • Q8N1X8
    • Q8TAB6

    Protein attributes for KIF19 Gene

    998 amino acids
    Molecular mass:
    111332 Da
    Quaternary structure:
    No Data Available
    • [Isoform 2]: Due to intron retention.
    • [Isoform 3]: Due to intron retention.

    Alternative splice isoforms for KIF19 Gene


neXtProt entry for KIF19 Gene

Post-translational modifications for KIF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF19 Gene

Domains & Families for KIF19 Gene

Gene Families for KIF19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF19 Gene

GenScript: Design optimal peptide antigens:
  • Kinesin-like protein KIF19 (KIF19_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF19: view

Function for KIF19 Gene

Molecular function for KIF19 Gene

UniProtKB/Swiss-Prot Function:
Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.

Phenotypes From GWAS Catalog for KIF19 Gene

Gene Ontology (GO) - Molecular Function for KIF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IBA 21873635
genes like me logo Genes that share ontologies with KIF19: view
genes like me logo Genes that share phenotypes with KIF19: view

Animal Models for KIF19 Gene

MGI Knock Outs for KIF19:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KIF19 Gene

Localization for KIF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF19 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Localizes to cilia tips. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF19 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Centrosome (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA 21873635
GO:0005874 microtubule IBA 21873635
GO:0005929 cilium ISS --
genes like me logo Genes that share ontologies with KIF19: view

Pathways & Interactions for KIF19 Gene

genes like me logo Genes that share pathways with KIF19: view

Gene Ontology (GO) - Biological Process for KIF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA 21873635
GO:0060404 axonemal microtubule depolymerization IEA,ISS --
GO:0070462 plus-end specific microtubule depolymerization IEA,ISS --
genes like me logo Genes that share ontologies with KIF19: view

No data available for SIGNOR curated interactions for KIF19 Gene

Drugs & Compounds for KIF19 Gene

No Compound Related Data Available

Transcripts for KIF19 Gene

mRNA/cDNA for KIF19 Gene

12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF19

Alternative Splicing Database (ASD) splice patterns (SP) for KIF19 Gene

No ASD Table

Relevant External Links for KIF19 Gene

GeneLoc Exon Structure for

Expression for KIF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF19 Gene

mRNA differential expression in normal tissues according to GTEx for KIF19 Gene

This gene is overexpressed in Nerve - Tibial (x17.0) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for KIF19 Gene

This gene is overexpressed in Cervix (57.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIF19 Gene

Protein tissue co-expression partners for KIF19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF19

SOURCE GeneReport for Unigene cluster for KIF19 Gene:


Evidence on tissue expression from TISSUES for KIF19 Gene

  • Nervous system(4.6)
  • Liver(4)
genes like me logo Genes that share expression patterns with KIF19: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF19 Gene

Orthologs for KIF19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIF19 30
  • 94.95 (n)
-- 31
  • 21 (a)
(Canis familiaris)
Mammalia KIF19 30 31
  • 90.2 (n)
(Mus musculus)
Mammalia Kif19a 30 17 31
  • 86.76 (n)
(Rattus norvegicus)
Mammalia Kif19 30
  • 84.71 (n)
(Bos Taurus)
Mammalia KIF19 30 31
  • 84.45 (n)
(Monodelphis domestica)
Mammalia KIF19 31
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia KIF19 31
  • 62 (a)
(Gallus gallus)
Aves KIF19 31
  • 61 (a)
(Anolis carolinensis)
Reptilia KIF19 31
  • 65 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kif19 30
  • 76.18 (n)
(Danio rerio)
Actinopterygii kif19 30 31
  • 64.35 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Kif19A 30 31
  • 53.34 (n)
(Caenorhabditis elegans)
Secernentea klp-13 30 31
  • 48.03 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP3 31
  • 26 (a)
Species where no ortholog for KIF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KIF19 Gene

Gene Tree for KIF19 (if available)
Gene Tree for KIF19 (if available)
Evolutionary constrained regions (ECRs) for KIF19: view image

Paralogs for KIF19 Gene

(8) SIMAP similar genes for KIF19 Gene using alignment to 2 proteins:

  • F8VW50_HUMAN
genes like me logo Genes that share paralogs with KIF19: view

Variants for KIF19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF19 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs34016821 Likely Benign: not provided 74,344,842(+) G/A
NM_153209.4(KIF19):c.664G>A (p.Ala222Thr)
rs532366391 Benign: not provided 74,344,293(+) AG/A
NM_153209.4(KIF19):c.532del (p.Gly177_Val178insTer)
rs78437913 Benign: not provided 74,349,251(+) G/A
NM_153209.4(KIF19):c.1115G>A (p.Arg372Gln)
rs2271535 - p.Arg807His
rs2382644 - p.Arg471Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KIF19 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KIF19 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5770n54 CNV loss 21841781
dgv5771n54 CNV loss 21841781
dgv5772n54 CNV loss 21841781
dgv5773n54 CNV loss 21841781
esv2657435 CNV deletion 23128226
esv2660286 CNV deletion 23128226
esv2716214 CNV deletion 23290073
esv2716215 CNV deletion 23290073
esv2716216 CNV deletion 23290073
esv2716217 CNV deletion 23290073
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv29259 CNV loss 19812545
esv33995 CNV loss 17666407
esv3554769 CNV deletion 23714750
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641237 CNV gain 21293372
esv3641239 CNV loss 21293372
esv3641240 CNV loss 21293372
nsv509673 CNV insertion 20534489
nsv517569 CNV gain+loss 19592680
nsv576005 CNV loss 21841781
nsv576020 CNV loss 21841781
nsv833538 CNV gain 17160897
nsv833539 CNV loss 17160897

Variation tolerance for KIF19 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.46; 95.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF19 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF19 Gene

Disorders for KIF19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF19 Gene - From: COP

Disorder Aliases PubMed IDs
orofaciodigital syndrome i
  • ofd1
- elite association - COSMIC cancer census association via MalaCards
Search KIF19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF19

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KIF19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF19 Gene

Publications for KIF19 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H … Hirokawa N (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3

Products for KIF19 Gene

Sources for KIF19 Gene