KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008] See more...

Aliases for KIF18A Gene

Aliases for KIF18A Gene

  • Kinesin Family Member 18A 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 99 2 3
  • Kinesin-Like Protein KIF18A 3 4
  • MS-KIF18A 3 4
  • PPP1R99 2 3
  • Marrow Stromal KIF18A 4
  • DKFZP434G2226 2
  • KIF18A 5

External Ids for KIF18A Gene

Previous GeneCards Identifiers for KIF18A Gene

  • GC11M027998
  • GC11M027740
  • GC11M028042

Summaries for KIF18A Gene

Entrez Gene Summary for KIF18A Gene

  • KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]

GeneCards Summary for KIF18A Gene

KIF18A (Kinesin Family Member 18A) is a Protein Coding gene. Diseases associated with KIF18A include Asbestosis and Goldberg-Shprintzen Syndrome. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include actin binding and microtubule motor activity. An important paralog of this gene is KIF18B.

UniProtKB/Swiss-Prot Summary for KIF18A Gene

  • Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.

Gene Wiki entry for KIF18A Gene

Additional gene information for KIF18A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF18A Gene

Genomics for KIF18A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIF18A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J028105 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 614.1 -0.5 -487 6.3 BRCA1 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 TFE3 KIF18A METTL15 HSALNG0083331 lnc-BDNF-7 BDNF lnc-KIF18A-2
GH11J027413 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +684.4 684379 23.6 TEAD4 PRDM10 ZNF629 RFX1 LEF1 IKZF1 ZNF692 JUND FOXA1 DDX20 LGR4 LGR4-AS1 LIN7C KIF18A lnc-BBOX1-10 lnc-CCDC34-6 CCDC34
GH11J027932 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +174.1 174079 3.8 SP1 JUND CEBPB FOS JUN USF1 RCOR1 MAX MAZ EP300 KIF18A BDNF HSALNG0083320 piR-49322-091 HSALNG0083326
GH11J028049 Enhancer 0.9 Ensembl ENCODE 4.5 +58.9 58852 2.3 ZNF629 PKNOX1 REST SP1 ZNF639 SMARCC1 JUND ZXDB ATF3 ZEB1 KIF18A piR-39858-086 MIR610 BDNF
GH11J028140 Enhancer 0.6 Ensembl ENCODE 5.3 -33.0 -32992 1.4 ZNF316 FOS JUND ZNF217 ZNF680 KIF18A ENSG00000271332 lnc-KIF18A-3 lnc-KIF18A-2 METTL15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF18A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF18A

Top Transcription factor binding sites by QIAGEN in the KIF18A gene promoter:
  • AML1a
  • Chx10
  • Lhx3a
  • LHX3b
  • Nkx2-5
  • p53
  • POU6F1 (c2)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for KIF18A Gene

Genomic Locations for KIF18A Gene
chr11:28,020,619-28,108,180
(GRCh38/hg38)
Size:
87,562 bases
Orientation:
Minus strand
chr11:28,042,163-28,129,855
(GRCh37/hg19)
Size:
87,693 bases
Orientation:
Minus strand

Genomic View for KIF18A Gene

Genes around KIF18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF18A Gene

Proteins for KIF18A Gene

  • Protein details for KIF18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI77-KI18A_HUMAN
    Recommended name:
    Kinesin-like protein KIF18A
    Protein Accession:
    Q8NI77
    Secondary Accessions:
    • Q4VPE3
    • Q86VS5
    • Q9H0F3

    Protein attributes for KIF18A Gene

    Size:
    898 amino acids
    Molecular mass:
    102281 Da
    Quaternary structure:
    • Interacts with CENPE and ESR1.

    Three dimensional structures from OCA and Proteopedia for KIF18A Gene

neXtProt entry for KIF18A Gene

Post-translational modifications for KIF18A Gene

Other Protein References for KIF18A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF18A Gene

Domains & Families for KIF18A Gene

Gene Families for KIF18A Gene

Protein Domains for KIF18A Gene

Suggested Antigen Peptide Sequences for KIF18A Gene

GenScript: Design optimal peptide antigens:
  • Marrow stromal KIF18A (KI18A_HUMAN)
  • KIF18A protein (Q4G194_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NI77

UniProtKB/Swiss-Prot:

KI18A_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF18A: view

Function for KIF18A Gene

Molecular function for KIF18A Gene

UniProtKB/Swiss-Prot Function:
Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
UniProtKB/Swiss-Prot Induction:
By estrogen.

Phenotypes From GWAS Catalog for KIF18A Gene

Gene Ontology (GO) - Molecular Function for KIF18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003777 microtubule motor activity IBA 21873635
GO:0003779 actin binding IPI 18680169
GO:0005515 protein binding IPI 15231748
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF18A: view
genes like me logo Genes that share phenotypes with KIF18A: view

Animal Models for KIF18A Gene

MGI Knock Outs for KIF18A:

Animal Model Products

CRISPR Products

miRNA for KIF18A Gene

miRTarBase miRNAs that target KIF18A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF18A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF18A Gene

Localization for KIF18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF18A Gene

Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF18A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Microtubules (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0001726 ruffle IEA,IDA 17006958
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,IDA 17006958
GO:0005737 cytoplasm IEA,IDA 17006958
genes like me logo Genes that share ontologies with KIF18A: view

Pathways & Interactions for KIF18A Gene

genes like me logo Genes that share pathways with KIF18A: view

Gene Ontology (GO) - Biological Process for KIF18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA 21873635
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007019 microtubule depolymerization IDA 17346968
GO:0007080 mitotic metaphase plate congression IEA,IDA 17346968
genes like me logo Genes that share ontologies with KIF18A: view

No data available for SIGNOR curated interactions for KIF18A Gene

Drugs & Compounds for KIF18A Gene

No Compound Related Data Available

Transcripts for KIF18A Gene

mRNA/cDNA for KIF18A Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF18A

Alternative Splicing Database (ASD) splice patterns (SP) for KIF18A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - -
SP2: - -
SP3:
SP4: - -
SP5: - -
SP6: -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF18A Gene

GeneLoc Exon Structure for
KIF18A

Expression for KIF18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF18A Gene

mRNA differential expression in normal tissues according to GTEx for KIF18A Gene

This gene is overexpressed in Testis (x11.6).

Protein differential expression in normal tissues from HIPED for KIF18A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (26.2), Monocytes (20.0), Fetal heart (11.3), and Lung (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF18A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF18A

SOURCE GeneReport for Unigene cluster for KIF18A Gene:

Hs.301052
genes like me logo Genes that share expression patterns with KIF18A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF18A Gene

Orthologs for KIF18A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF18A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIF18A 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIF18A 30 31
  • 89.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KIF18A 30 31
  • 88.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Kif18a 30 17 31
  • 81.6 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kif18a 30
  • 80.35 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia KIF18A 31
  • 72 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KIF18A 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIF18A 30 31
  • 68.94 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIF18A 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kif18a 30
  • 63.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398650 30
Zebrafish
(Danio rerio)
Actinopterygii kif18a 30 31
  • 56.07 (n)
OneToOne
zgc55995 30
Fruit Fly
(Drosophila melanogaster)
Insecta Klp67A 31
  • 32 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP3 31
  • 29 (a)
OneToMany
Species where no ortholog for KIF18A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KIF18A Gene

ENSEMBL:
Gene Tree for KIF18A (if available)
TreeFam:
Gene Tree for KIF18A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF18A: view image

Paralogs for KIF18A Gene

(8) SIMAP similar genes for KIF18A Gene using alignment to 2 proteins:

  • KI18A_HUMAN
  • Q4G194_HUMAN
genes like me logo Genes that share paralogs with KIF18A: view

Variants for KIF18A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF18A Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
720712 Benign: not provided 28,021,252(-) G/A MISSENSE_VARIANT
769798 Benign: not provided 28,023,820(-) G/A SYNONYMOUS_VARIANT
rs10458896 - p.Ile735Val
rs12272419 - p.Thr273Ala
rs34913484 - p.Pro334Ser

Additional dbSNP identifiers (rs#s) for KIF18A Gene

Structural Variations from Database of Genomic Variants (DGV) for KIF18A Gene

Variant ID Type Subtype PubMed ID
esv2744299 CNV deletion 23290073
esv3579455 CNV loss 25503493
esv3891958 CNV gain 25118596
esv9041 CNV gain 19470904
nsv1040043 CNV loss 25217958
nsv553915 CNV loss 21841781
nsv832096 CNV loss 17160897

Variation tolerance for KIF18A Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF18A Gene

Human Gene Mutation Database (HGMD)
KIF18A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF18A Gene

Disorders for KIF18A Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIF18A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
asbestosis
  • idiopathic interstitial pneumonitis - from asbestos exposure
goldberg-shprintzen syndrome
  • goshs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KIF18A

genes like me logo Genes that share disorders with KIF18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF18A Gene

Publications for KIF18A Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E. (PMID: 19625775) Huang Y … Dai W (Cell cycle (Georgetown, Tex.) 2009) 3 4
  3. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. (PMID: 18267093) Stumpff J … Wordeman L (Developmental cell 2008) 3 4
  4. New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A. (PMID: 18680169) Zusev M … Benayahu D (Journal of cellular physiology 2008) 3 4
  5. MS-KIF18A, a kinesin, is associated with estrogen receptor. (PMID: 17006958) Luboshits G … Benayahu D (Journal of cellular biochemistry 2007) 3 4

Products for KIF18A Gene

Sources for KIF18A Gene