Aliases for KIF18A Gene
External Ids for KIF18A Gene
Previous GeneCards Identifiers for KIF18A Gene
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
GeneCards Summary for KIF18A Gene
KIF18A (Kinesin Family Member 18A) is a Protein Coding gene. Diseases associated with KIF18A include Asbestosis and Goldberg-Shprintzen Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding and microtubule motor activity. An important paralog of this gene is KIF18B.
UniProtKB/Swiss-Prot for KIF18A Gene
Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.