Free for academic non-profit institutions. Other users need a Commercial license
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
KIF18A (Kinesin Family Member 18A) is a Protein Coding gene. Diseases associated with KIF18A include Asbestosis and Goldberg-Shprintzen Syndrome. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include actin binding and microtubule motor activity. An important paralog of this gene is KIF18B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003777 | microtubule motor activity | IBA | 21873635 |
GO:0003779 | actin binding | IPI | 18680169 |
GO:0005515 | protein binding | IPI | 15231748 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000776 | kinetochore | IEA | -- |
GO:0001726 | ruffle | IEA,IDA | 17006958 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IBA,IDA | 17006958 |
GO:0005737 | cytoplasm | IEA,IDA | 17006958 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Golgi-to-ER retrograde transport |
.52
|
|
2 | Cell Cycle, Mitotic |
.83
|
.60
|
3 | Mitotic Metaphase and Anaphase |
.94
|
|
4 | Mitotic Prometaphase | ||
5 | Vesicle-mediated transport |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000070 | mitotic sister chromatid segregation | IBA | 21873635 |
GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | TAS | -- |
GO:0007018 | microtubule-based movement | TAS | -- |
GO:0007019 | microtubule depolymerization | IDA | 17346968 |
GO:0007080 | mitotic metaphase plate congression | IEA,IDA | 17346968 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - |
ExUns: | 18 |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: | |
SP6: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KIF18A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KIF18A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KIF18A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Kif18a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Kif18a 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | KIF18A 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | KIF18A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | KIF18A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | KIF18A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kif18a 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398650 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | kif18a 30 31 |
|
OneToOne | |
zgc55995 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Klp67A 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | KIP3 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
720712 | Benign: not provided | 28,021,252(-) | G/A | MISSENSE_VARIANT | |
769798 | Benign: not provided | 28,023,820(-) | G/A | SYNONYMOUS_VARIANT | |
rs10458896 | - | p.Ile735Val | |||
rs12272419 | - | p.Thr273Ala | |||
rs34913484 | - | p.Pro334Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2744299 | CNV | deletion | 23290073 |
esv3579455 | CNV | loss | 25503493 |
esv3891958 | CNV | gain | 25118596 |
esv9041 | CNV | gain | 19470904 |
nsv1040043 | CNV | loss | 25217958 |
nsv553915 | CNV | loss | 21841781 |
nsv832096 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
asbestosis |
|
|
goldberg-shprintzen syndrome |
|
|