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Aliases for KIF17 Gene

Aliases for KIF17 Gene

  • Kinesin Family Member 17 2 3 5
  • KIF3-Related Motor Protein 2 3 4
  • Kinesin-Like Protein KIF17 2 3
  • KIF17 Variant Protein 2 3
  • KIF3X 3 4
  • KIAA1405 4
  • KIF17B 3
  • KLP-2 3
  • OSM-3 3

External Ids for KIF17 Gene

Previous GeneCards Identifiers for KIF17 Gene

  • GC01M020560
  • GC01M020026
  • GC01M020136
  • GC01M020459
  • GC01M020735
  • GC01M020863
  • GC01M020990
  • GC01M019236

Summaries for KIF17 Gene

GeneCards Summary for KIF17 Gene

KIF17 (Kinesin Family Member 17) is a Protein Coding gene. Diseases associated with KIF17 include Sulfhemoglobinemia. Among its related pathways are Transcription_CREM signaling in testis and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF3B.

UniProtKB/Swiss-Prot for KIF17 Gene

  • Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Gene Wiki entry for KIF17 Gene

Additional gene information for KIF17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF17 Gene

Genomics for KIF17 Gene

GeneHancer (GH) Regulatory Elements for KIF17 Gene

Promoters and enhancers for KIF17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J020717 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 663.7 +0.1 56 1.1 ATF1 RB1 SIN3A BMI1 ZEB1 ZNF335 GLIS2 SCRT2 ATF7 CREM KIF17 EIF4G3 GC01P020706
GH01J020695 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 655.7 +20.2 20183 4.1 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZNF213 KIF17 EIF4G3 HP1BP3 ENSG00000235432 GC01P020706
GH01J020683 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 650.3 +32.9 32889 2.6 SP1 ZSCAN4 MAX NR2F2 EGR2 KIF17 PINK1 ENSG00000233069 SH2D5 UBXN10-AS1 EIF4G3 ENSG00000235432 DDOST
GH01J020366 Enhancer 0.5 FANTOM5 8.5 +351.3 351345 0.1 ZNF335 ZNF143 ZBTB26 EZH2 KIF17 PINK1 GC01P020350 PIR44198 LINC01141
GH01J021187 Enhancer 0.3 FANTOM5 10.9 -469.9 -469889 0.1 ZSCAN16 KIF17 MIR1256 EIF4G3 GC01M021203
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF17 gene promoter:
  • AP-4
  • p53
  • deltaCREB
  • CREB
  • LCR-F1
  • AML1a
  • ATF
  • Olf-1
  • Tal-1beta
  • ITF-2

Genomic Locations for KIF17 Gene

Genomic Locations for KIF17 Gene
chr1:20,661,643-20,718,017
(GRCh38/hg38)
Size:
56,375 bases
Orientation:
Minus strand
chr1:20,990,507-21,044,510
(GRCh37/hg19)
Size:
54,004 bases
Orientation:
Minus strand

Genomic View for KIF17 Gene

Genes around KIF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF17 Gene

Proteins for KIF17 Gene

  • Protein details for KIF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E2-KIF17_HUMAN
    Recommended name:
    Kinesin-like protein KIF17
    Protein Accession:
    Q9P2E2
    Secondary Accessions:
    • A2A3Q7
    • A2A3Q8
    • O95077
    • Q53YS6
    • Q5VWA9
    • Q6GSA8
    • Q8N411

    Protein attributes for KIF17 Gene

    Size:
    1029 amino acids
    Molecular mass:
    115068 Da
    Quaternary structure:
    • Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By similarity).
    SequenceCaution:
    • Sequence=AAD01428.1; Type=Frameshift; Positions=970, 990; Evidence={ECO:0000305}; Sequence=AAD01428.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH36871.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA92643.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAH73471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23390.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF17 Gene

Post-translational modifications for KIF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF17 Gene

No data available for DME Specific Peptides for KIF17 Gene

Domains & Families for KIF17 Gene

Gene Families for KIF17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2E2

UniProtKB/Swiss-Prot:

KIF17_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF17: view

Function for KIF17 Gene

Molecular function for KIF17 Gene

UniProtKB/Swiss-Prot Function:
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Phenotypes From GWAS Catalog for KIF17 Gene

Gene Ontology (GO) - Molecular Function for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA,IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF17: view
genes like me logo Genes that share phenotypes with KIF17: view

Animal Models for KIF17 Gene

MGI Knock Outs for KIF17:

Animal Model Products

miRNA for KIF17 Gene

miRTarBase miRNAs that target KIF17

Clone Products

  • Addgene plasmids for KIF17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF17 Gene

Localization for KIF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF17 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF17 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 3
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IBA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA,IEA --
genes like me logo Genes that share ontologies with KIF17: view

Pathways & Interactions for KIF17 Gene

genes like me logo Genes that share pathways with KIF17: view

Pathways by source for KIF17 Gene

1 GeneGo (Thomson Reuters) pathway for KIF17 Gene

Gene Ontology (GO) - Biological Process for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
GO:0007018 microtubule-based movement IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0022008 neurogenesis IBA --
genes like me logo Genes that share ontologies with KIF17: view

No data available for SIGNOR curated interactions for KIF17 Gene

Drugs & Compounds for KIF17 Gene

No Compound Related Data Available

Transcripts for KIF17 Gene

mRNA/cDNA for KIF17 Gene

Unigene Clusters for KIF17 Gene

Kinesin family member 17:
Representative Sequences:

Clone Products

  • Addgene plasmids for KIF17

Alternative Splicing Database (ASD) splice patterns (SP) for KIF17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for KIF17 Gene

GeneLoc Exon Structure for
KIF17
ECgene alternative splicing isoforms for
KIF17

Expression for KIF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF17 Gene

This gene is overexpressed in Testis (x9.8), Spleen (x4.3), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for KIF17 Gene

This gene is overexpressed in Stomach (33.3), Cervix (18.1), and Heart (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIF17 Gene



Protein tissue co-expression partners for KIF17 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF17 Gene:

KIF17

SOURCE GeneReport for Unigene cluster for KIF17 Gene:

Hs.130411

Evidence on tissue expression from TISSUES for KIF17 Gene

  • Nervous system(4.5)
  • Eye(4.4)
genes like me logo Genes that share expression patterns with KIF17: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF17 Gene

Orthologs for KIF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF17 34 33
  • 99.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIF17 34 33
  • 86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIF17 34 33
  • 83.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kif17 16 34 33
  • 82 (n)
rat
(Rattus norvegicus)
Mammalia Kif17 33
  • 81.22 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF17 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF17 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF17 34
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15538 33
zebrafish
(Danio rerio)
Actinopterygii kif17 34 33
  • 66.13 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003323 33
  • 56.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kif3C 34 33
  • 50.65 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea osm-3 34 33
  • 57.55 (n)
OneToOne
Species where no ortholog for KIF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF17 Gene

ENSEMBL:
Gene Tree for KIF17 (if available)
TreeFam:
Gene Tree for KIF17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF17: view image

Paralogs for KIF17 Gene

(10) SIMAP similar genes for KIF17 Gene using alignment to 1 proteins:

  • KIF17_HUMAN
genes like me logo Genes that share paralogs with KIF17: view

Variants for KIF17 Gene

Sequence variations from dbSNP and Humsavar for KIF17 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014120 -- 20,702,703(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000046022 -- 20,665,798(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000130630 -- 20,717,062(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000180022 -- 20,689,278(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000270889 -- 20,688,270(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF17 Gene

Variant ID Type Subtype PubMed ID
esv2667782 CNV deletion 23128226
esv3585428 CNV loss 21293372
esv3585429 CNV loss 21293372
esv3585430 CNV loss 21293372
nsv1003348 CNV gain 25217958
nsv1113087 CNV deletion 24896259
nsv520013 CNV loss 19592680
nsv522796 CNV loss 19592680
nsv545731 CNV gain 21841781
nsv834369 CNV loss 17160897

Variation tolerance for KIF17 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF17 Gene

Human Gene Mutation Database (HGMD)
KIF17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF17 Gene

Disorders for KIF17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF17 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
sulfhemoglobinemia
  • sulfemoglobinemia
- elite association - COSMIC cancer census association via MalaCards
Search KIF17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIF17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF17 Gene

Publications for KIF17 Gene

  1. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. (PMID: 14673085) Chennathukuzhi V … Hecht NB (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58

Products for KIF17 Gene

Sources for KIF17 Gene

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