The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010] See more...

Aliases for KIF16B Gene

Aliases for KIF16B Gene

  • Kinesin Family Member 16B 2 3 5
  • SNX23 2 3 4
  • Kinesin-Like Protein KIF16B 3 4
  • C20orf23 3 4
  • Testis Secretory Sperm-Binding Protein Li 201a 3
  • Chromosome 20 Open Reading Frame 23 2
  • Kinesin Motor Protein 3
  • Sorting Nexin 23 3
  • Sorting Nexin-23 4
  • KISC20ORF 3
  • DJ971B4.1 2
  • FLJ20135 2
  • KIAA1590 4
  • KIF16B 5

External Ids for KIF16B Gene

Previous HGNC Symbols for KIF16B Gene

  • C20orf23

Previous GeneCards Identifiers for KIF16B Gene

  • GC20M016201
  • GC20M016252

Summaries for KIF16B Gene

Entrez Gene Summary for KIF16B Gene

  • The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for KIF16B Gene

KIF16B (Kinesin Family Member 16B) is a Protein Coding gene. Diseases associated with KIF16B include Small Intestine Neuroendocrine Neoplasm. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and Rab GTPase binding. An important paralog of this gene is KIF1A.

UniProtKB/Swiss-Prot Summary for KIF16B Gene

  • Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Gene Wiki entry for KIF16B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIF16B Gene

Genomics for KIF16B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIF16B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J016571 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 649.6 -0.4 -398 4.5 SP1 HNRNPL GATAD2A PRDM10 TFE3 IKZF1 NFKBIZ RFX5 KDM1A ZNF692 KIF16B ENSG00000273998 DSTN ENSG00000275728 SNRPB2
GH20J016578 Enhancer 1 FANTOM5 Ensembl ENCODE 48.8 -7.0 -6950 3 ZNF629 FOXA1 ZBTB44 CEBPB FOXA2 TSHZ1 ZSCAN5C OSR2 PKNOX1 KLF8 ENSG00000275728 KIF16B SNRPB2 ENSG00000228809 ENSG00000273998 lnc-KIF16B-5
GH20J016526 Enhancer 1 Ensembl ENCODE 38.9 +44.7 44656 6 CEBPG CREB1 GATAD2A TFE3 NFKBIZ CTCF ZHX2 JUND FOXA1 RXRB piR-32214-389 KIF16B ENSG00000228809 SNRPB2 piR-56883-099
GH20J016606 Enhancer 0.9 Ensembl ENCODE 34.4 -34.9 -34854 3.4 GATAD2A REST RXRB SP1 ZNF341 ZSCAN5C OSR2 YY1 JUND NR2F2 lnc-SNRPB2-1 KIF16B LOC105372542 SNRPB2
GH20J016532 Enhancer 0.7 Ensembl ENCODE 42.2 +37.3 37305 7.9 SCRT2 CREB1 SCRT1 ZFHX2 SPI1 ATF4 CEBPG HLF EGR2 KIF16B SNRPB2 ENSG00000228809 piR-32214-389 piR-39858-368
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF16B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIF16B

Top Transcription factor binding sites by QIAGEN in the KIF16B gene promoter:
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • POU2F2

Genomic Locations for KIF16B Gene

Genomic Locations for KIF16B Gene
chr20:16,272,104-16,573,457
(GRCh38/hg38)
Size:
301,354 bases
Orientation:
Minus strand
chr20:16,252,749-16,554,079
(GRCh37/hg19)
Size:
301,331 bases
Orientation:
Minus strand

Genomic View for KIF16B Gene

Genes around KIF16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF16B Gene

Proteins for KIF16B Gene

  • Protein details for KIF16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L93-KI16B_HUMAN
    Recommended name:
    Kinesin-like protein KIF16B
    Protein Accession:
    Q96L93
    Secondary Accessions:
    • A6NKJ9
    • A7E2A8
    • B1AKG3
    • B1AKT7
    • C9JDN5
    • C9JI52
    • C9JSM8
    • C9JWJ7
    • Q2TBF5
    • Q5HYC0
    • Q5HYK1
    • Q5JWW3
    • Q5TFK5
    • Q86VL9
    • Q86YS5
    • Q8IYU0
    • Q9BQJ8
    • Q9BQM0
    • Q9BQM1
    • Q9BQM5
    • Q9H5U0
    • Q9HCI2
    • Q9NXN9

    Protein attributes for KIF16B Gene

    Size:
    1317 amino acids
    Molecular mass:
    152011 Da
    Quaternary structure:
    • Interacts with RAB14 (By similarity). Interacts with PTPN21.
    SequenceCaution:
    • Sequence=BAA90971.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA90971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB13416.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15530.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF16B Gene

    Alternative splice isoforms for KIF16B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF16B Gene

Post-translational modifications for KIF16B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF16B Gene

Domains & Families for KIF16B Gene

Gene Families for KIF16B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIF16B Gene

InterPro:
Blocks:
  • Forkhead-associated (FHA)
  • Phox-like
  • Kinesin, motor region
ProtoNet:

Suggested Antigen Peptide Sequences for KIF16B Gene

GenScript: Design optimal peptide antigens:
  • Sorting nexin-23 (KI16B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96L93

UniProtKB/Swiss-Prot:

KI16B_HUMAN :
  • The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF16B: view

Function for KIF16B Gene

Molecular function for KIF16B Gene

UniProtKB/Swiss-Prot Function:
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Phenotypes From GWAS Catalog for KIF16B Gene

Gene Ontology (GO) - Molecular Function for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA,IBA 21873635
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF16B: view
genes like me logo Genes that share phenotypes with KIF16B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF16B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF16B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF16B Gene

Localization for KIF16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF16B Gene

Cytoplasm, cytoskeleton. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF16B gene
Compartment Confidence
endosome 5
cytoskeleton 4
cytosol 4
mitochondrion 3
lysosome 2
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA,IDA 17641687
GO:0005769 early endosome IDA 15882625
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF16B: view

Pathways & Interactions for KIF16B Gene

genes like me logo Genes that share pathways with KIF16B: view

Gene Ontology (GO) - Biological Process for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001704 formation of primary germ layer IEA,ISS --
GO:0001919 regulation of receptor recycling IMP 15882625
GO:0006895 Golgi to endosome transport IEA,ISS --
GO:0007018 microtubule-based movement IEA,IBA 21873635
GO:0007173 epidermal growth factor receptor signaling pathway IMP 15882625
genes like me logo Genes that share ontologies with KIF16B: view

No data available for SIGNOR curated interactions for KIF16B Gene

Drugs & Compounds for KIF16B Gene

(2) Drugs for KIF16B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KIF16B: view

Transcripts for KIF16B Gene

mRNA/cDNA for KIF16B Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIF16B

Alternative Splicing Database (ASD) splice patterns (SP) for KIF16B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for KIF16B Gene

GeneLoc Exon Structure for
KIF16B

Expression for KIF16B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF16B Gene

This gene is overexpressed in Plasma (22.6), Liver (17.8), and Stomach (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF16B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIF16B

SOURCE GeneReport for Unigene cluster for KIF16B Gene:

Hs.101774

mRNA Expression by UniProt/SwissProt for KIF16B Gene:

Q96L93-KI16B_HUMAN
Tissue specificity: Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).

Evidence on tissue expression from TISSUES for KIF16B Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Liver(4.3)
  • Lung(4.3)
  • Blood(2.9)
  • Skin(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with KIF16B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF16B Gene

Orthologs for KIF16B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF16B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIF16B 31
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia KIF16B 31
  • 85 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kif16b 30
  • 84.61 (n)
Mouse
(Mus musculus)
Mammalia Kif16b 30 17 31
  • 84.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia KIF16B 31
  • 78 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia KIF16B 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIF16B 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KIF16B 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kif16b 30
  • 73.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100334507 30
  • 66.01 (n)
kif16ba 31
  • 61 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Klp98A 31
  • 33 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea klp-4 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
ManyToMany
Species where no ortholog for KIF16B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KIF16B Gene

ENSEMBL:
Gene Tree for KIF16B (if available)
TreeFam:
Gene Tree for KIF16B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIF16B: view image

Paralogs for KIF16B Gene

(9) SIMAP similar genes for KIF16B Gene using alignment to 3 proteins:

  • KI16B_HUMAN
  • H0Y534_HUMAN
  • J3QSY7_HUMAN
genes like me logo Genes that share paralogs with KIF16B: view

Variants for KIF16B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIF16B Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
711242 Benign: not provided 16,378,937(-) T/C MISSENSE_VARIANT
765003 Likely Benign: not provided 16,406,398(-) G/A SYNONYMOUS_VARIANT
777518 Benign: not provided 16,427,129(-) G/A SYNONYMOUS_VARIANT
780600 Benign: not provided 16,371,699(-) C/T MISSENSE_VARIANT
786365 Benign: not provided 16,511,518(-) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for KIF16B Gene

Structural Variations from Database of Genomic Variants (DGV) for KIF16B Gene

Variant ID Type Subtype PubMed ID
dgv1234e212 CNV loss 25503493
esv1729054 CNV insertion 17803354
esv2286171 CNV deletion 18987734
esv2763223 CNV gain 21179565
esv28081 CNV gain 19812545
esv2825 CNV loss 18987735
esv3556885 CNV deletion 23714750
esv3567909 CNV loss 25503493
esv3645404 CNV loss 21293372
esv3893318 CNV loss 25118596
nsv1057333 CNV gain 25217958
nsv1120127 OTHER inversion 24896259
nsv1129403 OTHER inversion 24896259
nsv1132898 CNV insertion 24896259
nsv179502 CNV insertion 16902084
nsv179537 CNV deletion 16902084
nsv180138 CNV deletion 16902084
nsv3305 CNV insertion 18451855
nsv523556 CNV loss 19592680
nsv833930 CNV gain 17160897
nsv833931 CNV loss 17160897

Variation tolerance for KIF16B Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF16B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF16B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF16B Gene

Disorders for KIF16B Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF16B Gene - From: DISEASES

Disorder Aliases PubMed IDs
small intestine neuroendocrine neoplasm
  • small intestine neuroendocrine tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KIF16B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KIF16B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF16B Gene

Publications for KIF16B Gene

  1. A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum. (PMID: 21139019) Walsh KM … Hoh J (Endocrine-related cancer 2011) 3 41
  2. The structural basis of novel endosome anchoring activity of KIF16B kinesin. (PMID: 17641687) Blatner NR … Cho W (The EMBO journal 2007) 3 4
  3. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet LF … Hong W (Biochimica et biophysica acta 2006) 2 3
  4. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. (PMID: 15882625) Hoepfner S … Zerial M (Cell 2005) 3 4
  5. Analysis of the kinesin superfamily: insights into structure and function. (PMID: 16084724) Miki H … Hirokawa N (Trends in cell biology 2005) 2 3

Products for KIF16B Gene

Sources for KIF16B Gene