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Aliases for KIF13B Gene

Aliases for KIF13B Gene

  • Kinesin Family Member 13B 2 3 5
  • Kinesin-Like Protein GAKIN 3 4
  • GAKIN 3 4
  • Guanylate Kinase Associated Kinesin 3
  • Kinesin-Like Protein KIF13B 3
  • Kinesin 13B 3
  • KIAA0639 4

External Ids for KIF13B Gene

Previous GeneCards Identifiers for KIF13B Gene

  • GC08M029510
  • GC08M028745
  • GC08M028946
  • GC08M028980
  • GC08M027469
  • GC08M028924

Summaries for KIF13B Gene

GeneCards Summary for KIF13B Gene

KIF13B (Kinesin Family Member 13B) is a Protein Coding gene. Diseases associated with KIF13B include Spastic Paraplegia 37, Autosomal Dominant and Spastic Paraplegia 11, Autosomal Recessive. Among its related pathways are Golgi-to-ER retrograde transport and Arf6 signaling events. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule motor activity. An important paralog of this gene is KIF13A.

UniProtKB/Swiss-Prot for KIF13B Gene

  • Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

Additional gene information for KIF13B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF13B Gene

Genomics for KIF13B Gene

GeneHancer (GH) Regulatory Elements for KIF13B Gene

Promoters and enhancers for KIF13B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J029257 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.5 2460 6.5 HDGF PKNOX1 ATF1 FOXA2 SIN3A ZNF48 YY1 ETS1 ZNF143 ATF7 KIF13B HMGB1P23
GH08J029224 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 32 +37.2 37246 2.6 HDGF ATF1 PKNOX1 FOXA2 ARNT IRF4 BRCA1 TCF12 ZNF766 GATA2 KIF13B ENSG00000254129 HMGB1P23
GH08J028888 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 +373.1 373122 4 FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF263 SP3 MEF2D GLIS1 RCOR2 INTS9 HMBOX1 KIF13B ENSG00000254129 RPL36AP32
GH08J029228 Enhancer 1.3 Ensembl ENCODE dbSUPER 21.1 +32.9 32927 3.7 PKNOX1 FOXA2 SMAD1 SIN3A IRF4 TCF12 ATF7 RUNX3 RXRA SMARCA4 KIF13B ENSG00000254129 HMGB1P23
GH08J029085 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.1 +177.2 177153 2 PKNOX1 FEZF1 GTF3C2 ZNF366 REST ZNF398 ZEB2 TSHZ1 ZNF843 ZNF217 KIF13B ZNF395 INTS9 ENSG00000259366 ENSG00000254129 ENSG00000259607
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIF13B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF13B gene promoter:
  • Meis-1b
  • CUTL1
  • HSF1 (long)
  • HSF1short
  • Meis-1
  • Meis-1a
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha

Genomic Locations for KIF13B Gene

Genomic Locations for KIF13B Gene
196,027 bases
Minus strand
195,847 bases
Minus strand

Genomic View for KIF13B Gene

Genes around KIF13B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF13B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF13B Gene

Proteins for KIF13B Gene

  • Protein details for KIF13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF13B
    Protein Accession:
    Secondary Accessions:
    • B4DGY5
    • B5MC45
    • F8VPJ2
    • O75134
    • Q9BYJ6

    Protein attributes for KIF13B Gene

    1826 amino acids
    Molecular mass:
    202789 Da
    Quaternary structure:
    • Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3.
    • Sequence=BAA31614.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF13B Gene

    Alternative splice isoforms for KIF13B Gene


neXtProt entry for KIF13B Gene

Post-translational modifications for KIF13B Gene

  • Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF13B Gene

Domains & Families for KIF13B Gene

Gene Families for KIF13B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF13B: view

Function for KIF13B Gene

Molecular function for KIF13B Gene

UniProtKB/Swiss-Prot Function:
Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

Phenotypes From GWAS Catalog for KIF13B Gene

Gene Ontology (GO) - Molecular Function for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA,NAS 10859302
GO:0005515 protein binding IEA,IPI 10859302
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF13B: view
genes like me logo Genes that share phenotypes with KIF13B: view

Animal Models for KIF13B Gene

MGI Knock Outs for KIF13B:

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF13B

miRNA for KIF13B Gene

miRTarBase miRNAs that target KIF13B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF13B Gene

Localization for KIF13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF13B Gene

Cytoplasm, cytoskeleton. Cell projection, axon. Note=accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF13B gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10859302
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF13B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF13B Gene

Pathways & Interactions for KIF13B Gene

genes like me logo Genes that share pathways with KIF13B: view

Gene Ontology (GO) - Biological Process for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting TAS 10859302
GO:0007018 microtubule-based movement TAS,IEA 10859302
GO:0007165 signal transduction NAS 10859302
GO:0030705 cytoskeleton-dependent intracellular transport IBA --
GO:0042110 T cell activation NAS 12496241
genes like me logo Genes that share ontologies with KIF13B: view

No data available for SIGNOR curated interactions for KIF13B Gene

Drugs & Compounds for KIF13B Gene

No Compound Related Data Available

Transcripts for KIF13B Gene

Unigene Clusters for KIF13B Gene

Kinesin family member 13B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF13B Gene

No ASD Table

Relevant External Links for KIF13B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF13B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF13B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF13B Gene

This gene is overexpressed in Nasal epithelium (10.6), Islet of Langerhans (7.1), and Salivary gland (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF13B Gene

Protein tissue co-expression partners for KIF13B Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF13B Gene:


SOURCE GeneReport for Unigene cluster for KIF13B Gene:


mRNA Expression by UniProt/SwissProt for KIF13B Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for KIF13B Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with KIF13B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF13B Gene

Orthologs for KIF13B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF13B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIF13B 34 33
  • 99.45 (n)
(Monodelphis domestica)
Mammalia KIF13B 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia KIF13B 34
  • 88 (a)
(Canis familiaris)
Mammalia KIF13B 34 33
  • 87.02 (n)
(Bos Taurus)
Mammalia KIF13B 34 33
  • 84.64 (n)
(Mus musculus)
Mammalia Kif13b 16 34 33
  • 83.35 (n)
(Rattus norvegicus)
Mammalia Kif13b 33
  • 82.48 (n)
(Gallus gallus)
Aves KIF13B 34 33
  • 75.5 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 91 (a)
-- 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif13b 33
  • 71.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24569 33
(Danio rerio)
Actinopterygii kif13bb 34
  • 72 (a)
kif13ba 34 33
  • 67.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta Khc-73 34 35 33
  • 56.21 (n)
Kif19A 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea klp-6 35
  • 43 (a)
klp-4 35
  • 42 (a)
Species where no ortholog for KIF13B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF13B Gene

Gene Tree for KIF13B (if available)
Gene Tree for KIF13B (if available)
Evolutionary constrained regions (ECRs) for KIF13B: view image

Paralogs for KIF13B Gene

Variants for KIF13B Gene

Sequence variations from dbSNP and Humsavar for KIF13B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000009903 -- 29,092,094(-) A/C intron_variant
rs1000027562 -- 29,160,555(-) T/C intron_variant
rs1000050115 -- 29,179,505(-) A/G intron_variant
rs1000054540 -- 29,145,545(-) C/T intron_variant
rs1000068270 -- 29,211,015(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF13B Gene

Variant ID Type Subtype PubMed ID
esv2501473 CNV deletion 19546169
esv2736816 CNV deletion 23290073
esv3572658 CNV loss 25503493
esv3572659 CNV loss 25503493
esv3616758 CNV loss 21293372
esv3616759 CNV loss 21293372
esv5693 CNV gain 19470904
nsv1030463 CNV loss 25217958
nsv528871 CNV loss 19592680
nsv610869 CNV loss 21841781
nsv831276 CNV gain 17160897
nsv951120 CNV deletion 24416366

Variation tolerance for KIF13B Gene

Residual Variation Intolerance Score: 2.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF13B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF13B Gene

Disorders for KIF13B Gene

MalaCards: The human disease database

(4) MalaCards diseases for KIF13B Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KIF13B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIF13B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF13B Gene

Publications for KIF13B Gene

  1. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PMID: 10859302) Hanada T … Chishti AH (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. (PMID: 16864656) Horiguchi K … Chishti AH (The Journal of cell biology 2006) 2 3 22 58
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58

Products for KIF13B Gene

Sources for KIF13B Gene

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