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Aliases for KIAA2026 Gene

Aliases for KIAA2026 Gene

  • KIAA2026 2 3

External Ids for KIAA2026 Gene

Previous GeneCards Identifiers for KIAA2026 Gene

  • GC09M005900
  • GC09M005909
  • GC09M005874
  • GC09M005919

Summaries for KIAA2026 Gene

GeneCards Summary for KIAA2026 Gene

KIAA2026 (KIAA2026) is a Protein Coding gene.

Additional gene information for KIAA2026 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA2026 Gene

Genomics for KIAA2026 Gene

GeneHancer (GH) Regulatory Elements for KIAA2026 Gene

Promoters and enhancers for KIAA2026 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I006006 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 536 3.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A YY1 ZNF213 ZNF207 KLF13 SP3 KIAA2026 MIR4665 UHRF2 RIC1 AK4P4 PDSS1P1 ERMP1
GH09I006679 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -673.7 -673721 4.8 HDGF FOXA2 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 IRF4 LOC105375968 AK4P4 UHRF2 KIAA2026 ENSG00000225489 GLDC KDM4C GC09P006678
GH09I005800 Enhancer 0.6 ENCODE 10.3 +207.3 207298 1.9 SMAD1 NFIA NFIB CEBPB EP300 RFX5 JUND LCORL GATA3 NFIC SNRPEP2 UHRF2 ERMP1 MLANA KIAA2026 RIC1 PIR31344
GH09I005623 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.4 +381.0 381035 7.5 PKNOX1 SMAD1 ARID4B SIN3A IRF4 POLR2B ZNF766 ZNF207 ZNF143 SP3 RIC1 LOC105375967 PLGRKT KIAA2026 CD274 RANBP6 GC09P005625
GH09I006024 Enhancer 0.8 Ensembl ENCODE 5.2 -15.7 -15722 0.4 CTCF ZBTB11 DPF2 RAD21 ZNF217 GATA3 IKZF1 SCRT2 PRDM10 CUX1 KIAA2026 RANBP6 ENSG00000228739
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIAA2026 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIAA2026 gene promoter:

Genomic Locations for KIAA2026 Gene

Genomic Locations for KIAA2026 Gene
chr9:5,859,595-6,008,479
(GRCh38/hg38)
Size:
148,885 bases
Orientation:
Minus strand
chr9:5,881,596-6,008,003
(GRCh37/hg19)

Genomic View for KIAA2026 Gene

Genes around KIAA2026 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA2026 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA2026 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA2026 Gene

Proteins for KIAA2026 Gene

  • Protein details for KIAA2026 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYC2-K2026_HUMAN
    Recommended name:
    Uncharacterized protein KIAA2026
    Protein Accession:
    Q5HYC2
    Secondary Accessions:
    • A8MTP2
    • B9EGW7
    • Q4VXA2
    • Q8IVE5

    Protein attributes for KIAA2026 Gene

    Size:
    2103 amino acids
    Molecular mass:
    228087 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI36847.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI45993.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI95313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA2026 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA2026 Gene

Post-translational modifications for KIAA2026 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KIAA2026 Gene

Domains & Families for KIAA2026 Gene

Gene Families for KIAA2026 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA2026 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA2026: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA2026 Gene

Function for KIAA2026 Gene

Phenotypes From GWAS Catalog for KIAA2026 Gene

genes like me logo Genes that share phenotypes with KIAA2026: view

Animal Model Products

miRNA for KIAA2026 Gene

miRTarBase miRNAs that target KIAA2026

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA2026 Gene

Localization for KIAA2026 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA2026 gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA2026 Gene

Pathways & Interactions for KIAA2026 Gene

SuperPathways for KIAA2026 Gene

No Data Available

Interacting Proteins for KIAA2026 Gene

Gene Ontology (GO) - Biological Process for KIAA2026 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA2026 Gene

Drugs & Compounds for KIAA2026 Gene

No Compound Related Data Available

Transcripts for KIAA2026 Gene

Unigene Clusters for KIAA2026 Gene

KIAA2026:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA2026 Gene

No ASD Table

Relevant External Links for KIAA2026 Gene

GeneLoc Exon Structure for
KIAA2026
ECgene alternative splicing isoforms for
KIAA2026

Expression for KIAA2026 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA2026 Gene

Protein differential expression in normal tissues from HIPED for KIAA2026 Gene

This gene is overexpressed in Esophagus (27.1), Plasma (12.1), Kidney (6.7), and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA2026 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA2026 Gene:

KIAA2026

SOURCE GeneReport for Unigene cluster for KIAA2026 Gene:

Hs.535060
genes like me logo Genes that share expression patterns with KIAA2026: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA2026 Gene

Orthologs for KIAA2026 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA2026 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA2026 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia KIAA2026 33 34
  • 90.81 (n)
cow
(Bos Taurus)
Mammalia KIAA2026 33 34
  • 90.55 (n)
mouse
(Mus musculus)
Mammalia 9930021J03Rik 33 16 34
  • 86.05 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311595 33
  • 84.76 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA2026 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA2026 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA2026 33 34
  • 69.7 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA2026 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa2026 33
  • 58.99 (n)
Str.20397 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18719 33
zebrafish
(Danio rerio)
Actinopterygii KIAA2026 (2 of 2) 34
  • 42 (a)
OneToMany
CABZ01088061.1 34
  • 17 (a)
OneToMany
Species where no ortholog for KIAA2026 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA2026 Gene

ENSEMBL:
Gene Tree for KIAA2026 (if available)
TreeFam:
Gene Tree for KIAA2026 (if available)

Paralogs for KIAA2026 Gene

No data available for Paralogs for KIAA2026 Gene

Variants for KIAA2026 Gene

Sequence variations from dbSNP and Humsavar for KIAA2026 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000001896 -- 6,009,235(-) C/T upstream_transcript_variant
rs1000006235 -- 5,888,399(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000054310 -- 5,899,100(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000056087 -- 5,874,376(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000068489 -- 6,002,453(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA2026 Gene

Variant ID Type Subtype PubMed ID
nsv613204 CNV loss 21841781
nsv1029665 CNV gain 25217958
nsv1015450 CNV loss 25217958

Variation tolerance for KIAA2026 Gene

Gene Damage Index Score: 4.83; 67.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA2026 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA2026

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA2026 Gene

Disorders for KIAA2026 Gene

Additional Disease Information for KIAA2026

No disorders were found for KIAA2026 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA2026 Gene

Publications for KIAA2026 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. (PMID: 24211586) Uhler JP … Gustafsson CM (Biochemical and biophysical research communications 2014) 3 58
  3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar FJ … Moffat J (Molecular systems biology 2013) 3 58
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3 58
  5. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk JB … O'Connor GT (BMC medical genetics 2007) 44 58

Products for KIAA2026 Gene

Sources for KIAA2026 Gene

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