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Aliases for KIAA2013 Gene

Aliases for KIAA2013 Gene

  • KIAA2013 2 3
  • Uncharacterized Protein KIAA2013 3
  • RP5-1077B9.1 3

External Ids for KIAA2013 Gene

Previous GeneCards Identifiers for KIAA2013 Gene

  • GC01M011908
  • GC01M011782
  • GC01M011902
  • GC01M011971
  • GC01M011135

Summaries for KIAA2013 Gene

GeneCards Summary for KIAA2013 Gene

KIAA2013 (KIAA2013) is a Protein Coding gene.

Additional gene information for KIAA2013 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA2013 Gene

Genomics for KIAA2013 Gene

GeneHancer (GH) Regulatory Elements for KIAA2013 Gene

Promoters and enhancers for KIAA2013 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I011924 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.3 -269 4.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 KIAA2013 MFN2 CLCN6 FBXO44 PLOD1 NPPA-AS1
GH01I011978 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 -56.3 -56304 8.6 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MFN2 ENSG00000226849 EXOSC10 MIIP TNFRSF1B PLOD1 CLCN6 TARDBP KIAA2013 RNU5E-1
GH01I011879 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.4 +44.4 44418 4.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A POLR2B ZNF766 SP5 REST PLOD1 KIAA2013 NPPB RNU5E-4P RNU5E-1 NPPA-AS1 LOC102724659 C1orf167 LOC390997 ENSG00000226849
GH01I012018 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 -93.4 -93442 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF143 FOS MIIP UBIAD1 TNFRSF8 RNU6-777P RPL23AP89 PLOD1 KIAA2013 LINC01647 NPPA-AS1 ENSG00000202461
GH01I011907 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 7.3 +17.6 17631 3.1 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 RNU5E-1 RNU5E-4P TARDBP UBIAD1 ENSG00000226849 CLCN6 VPS13D SNORA59A MFN2 EXOSC10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIAA2013 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIAA2013 gene promoter:

Genomic Locations for KIAA2013 Gene

Genomic Locations for KIAA2013 Gene
chr1:11,919,588-11,926,428
(GRCh38/hg38)
Size:
6,841 bases
Orientation:
Minus strand
chr1:11,979,645-11,986,485
(GRCh37/hg19)

Genomic View for KIAA2013 Gene

Genes around KIAA2013 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA2013 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA2013 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA2013 Gene

Proteins for KIAA2013 Gene

  • Protein details for KIAA2013 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS2-K2013_HUMAN
    Recommended name:
    Uncharacterized protein KIAA2013
    Protein Accession:
    Q8IYS2
    Secondary Accessions:
    • Q5JXC1
    • Q8IVF8
    • Q8NDI7
    • Q9BSY1

    Protein attributes for KIAA2013 Gene

    Size:
    634 amino acids
    Molecular mass:
    69157 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23109.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA2013 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA2013 Gene

Post-translational modifications for KIAA2013 Gene

  • Glycosylation at isoforms=2224 and isoforms=2363

Other Protein References for KIAA2013 Gene

No data available for DME Specific Peptides for KIAA2013 Gene

Domains & Families for KIAA2013 Gene

Gene Families for KIAA2013 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for KIAA2013 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA2013: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA2013 Gene

Function for KIAA2013 Gene

Phenotypes From GWAS Catalog for KIAA2013 Gene

genes like me logo Genes that share phenotypes with KIAA2013: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA2013 Gene

Localization for KIAA2013 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA2013 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA2013 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIAA2013 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA2013: view

Pathways & Interactions for KIAA2013 Gene

SuperPathways for KIAA2013 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA2013 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA2013 Gene

Drugs & Compounds for KIAA2013 Gene

No Compound Related Data Available

Transcripts for KIAA2013 Gene

mRNA/cDNA for KIAA2013 Gene

Unigene Clusters for KIAA2013 Gene

KIAA2013:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA2013 Gene

No ASD Table

Relevant External Links for KIAA2013 Gene

GeneLoc Exon Structure for
KIAA2013
ECgene alternative splicing isoforms for
KIAA2013

Expression for KIAA2013 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA2013 Gene

mRNA differential expression in normal tissues according to GTEx for KIAA2013 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for KIAA2013 Gene

This gene is overexpressed in Cerebrospinal fluid (46.7) and Nasal epithelium (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA2013 Gene



Protein tissue co-expression partners for KIAA2013 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA2013 Gene:

KIAA2013

SOURCE GeneReport for Unigene cluster for KIAA2013 Gene:

Hs.520094

Evidence on tissue expression from TISSUES for KIAA2013 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with KIAA2013: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA2013 Gene

Orthologs for KIAA2013 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA2013 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA2013 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia KIAA2013 34
  • 94 (a)
OneToOne
LOC506454 33
  • 90.59 (n)
dog
(Canis familiaris)
Mammalia KIAA2013 33 34
  • 91.32 (n)
mouse
(Mus musculus)
Mammalia 2510039O18Rik 33 16 34
  • 87.96 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305350 33
  • 87.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA2013 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA2013 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA2013 33 34
  • 69.27 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA2013 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa2013 33
  • 58.6 (n)
Str.9454 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16770 33
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-104h9.5 33 34
  • 62.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7289 33 34
  • 48.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010005 33
  • 47.38 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C17H12.2 33
  • 37.65 (n)
C17H12.2 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3421 34
  • 42 (a)
OneToOne
Species where no ortholog for KIAA2013 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA2013 Gene

ENSEMBL:
Gene Tree for KIAA2013 (if available)
TreeFam:
Gene Tree for KIAA2013 (if available)

Paralogs for KIAA2013 Gene

(1) SIMAP similar genes for KIAA2013 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIAA2013: view

No data available for Paralogs for KIAA2013 Gene

Variants for KIAA2013 Gene

Sequence variations from dbSNP and Humsavar for KIAA2013 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000323305 -- 11,925,445(-) CCACCACCACCA/CCACCACCA coding_sequence_variant, inframe_deletion
rs1000569031 -- 11,924,994(-) T/C intron_variant
rs1000829410 -- 11,919,740(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001064270 -- 11,923,766(-) C/A intron_variant
rs1001499995 -- 11,924,906(-) T/A intron_variant

Variation tolerance for KIAA2013 Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA2013 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA2013

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIAA2013 Gene

Disorders for KIAA2013 Gene

Additional Disease Information for KIAA2013

No disorders were found for KIAA2013 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA2013 Gene

Publications for KIAA2013 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for KIAA2013 Gene

Sources for KIAA2013 Gene

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