Aliases for KIAA1841 Gene

Aliases for KIAA1841 Gene

  • KIAA1841 2 3
  • Uncharacterized Protein KIAA1841 3 4

External Ids for KIAA1841 Gene

Previous GeneCards Identifiers for KIAA1841 Gene

  • GC02P061432
  • GC02P061250
  • GC02P061267
  • GC02P061205
  • GC02P061293

Summaries for KIAA1841 Gene

GeneCards Summary for KIAA1841 Gene

KIAA1841 (KIAA1841) is a Protein Coding gene. Diseases associated with KIAA1841 include Peroxisome Biogenesis Disorder 11A.

Additional gene information for KIAA1841 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIAA1841 Gene

Genomics for KIAA1841 Gene

GeneHancer (GH) Regulatory Elements for KIAA1841 Gene

Promoters and enhancers for KIAA1841 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA1841 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIAA1841

Top Transcription factor binding sites by QIAGEN in the KIAA1841 gene promoter:
  • Bach2
  • CUTL1
  • Egr-3
  • HFH-1
  • Olf-1

Genomic Locations for KIAA1841 Gene

Genomic Locations for KIAA1841 Gene
chr2:61,065,870-61,157,942
(GRCh38/hg38)
Size:
92,073 bases
Orientation:
Plus strand
chr2:61,293,006-61,391,960
(GRCh37/hg19)
Size:
98,955 bases
Orientation:
Plus strand

Genomic View for KIAA1841 Gene

Genes around KIAA1841 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1841 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1841 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1841 Gene

Proteins for KIAA1841 Gene

  • Protein details for KIAA1841 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSI8-K1841_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1841
    Protein Accession:
    Q6NSI8
    Secondary Accessions:
    • Q49AF0
    • Q6ZND0
    • Q96JI6

    Protein attributes for KIAA1841 Gene

    Size:
    718 amino acids
    Molecular mass:
    82007 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47470.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1841 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1841 Gene

Post-translational modifications for KIAA1841 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1841 Gene

Domains & Families for KIAA1841 Gene

Gene Families for KIAA1841 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1841 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6NSI8

UniProtKB/Swiss-Prot:

K1841_HUMAN :
  • Belongs to the KIAA1841 family.
Family:
  • Belongs to the KIAA1841 family.
genes like me logo Genes that share domains with KIAA1841: view

No data available for Suggested Antigen Peptide Sequences for KIAA1841 Gene

Function for KIAA1841 Gene

Phenotypes From GWAS Catalog for KIAA1841 Gene

Phenotypes for KIAA1841 Gene

genes like me logo Genes that share phenotypes with KIAA1841: view

Animal Model Products

CRISPR Products

miRNA for KIAA1841 Gene

miRTarBase miRNAs that target KIAA1841

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1841

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1841 Gene

Localization for KIAA1841 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1841 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1841 Gene

Pathways & Interactions for KIAA1841 Gene

PathCards logo

SuperPathways for KIAA1841 Gene

No Data Available

Interacting Proteins for KIAA1841 Gene

;

Gene Ontology (GO) - Biological Process for KIAA1841 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1841 Gene

Drugs & Compounds for KIAA1841 Gene

No Compound Related Data Available

Transcripts for KIAA1841 Gene

mRNA/cDNA for KIAA1841 Gene

7 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1841

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1841 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 23b ^ 24 ^ 25
SP1: -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KIAA1841 Gene

GeneLoc Exon Structure for
KIAA1841

Expression for KIAA1841 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1841 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA1841 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1841 Gene



Protein tissue co-expression partners for KIAA1841 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIAA1841

SOURCE GeneReport for Unigene cluster for KIAA1841 Gene:

Hs.468653
genes like me logo Genes that share expression patterns with KIAA1841: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1841 Gene

Orthologs for KIAA1841 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1841 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1841 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1841 31 30
  • 92.15 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 0610010F05Rik 17 31 30
  • 88.21 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305110 30
  • 87.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1841 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1841 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1841 31 30
  • 77.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1841 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1841 30
  • 70.35 (n)
Str.19410 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.34417 30
zebrafish
(Danio rerio)
Actinopterygii LOC793832 30
  • 62.82 (n)
si:ch211-189k9.2 31
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6761 31 32
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToOne
Species where no ortholog for KIAA1841 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1841 Gene

ENSEMBL:
Gene Tree for KIAA1841 (if available)
TreeFam:
Gene Tree for KIAA1841 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIAA1841: view image

Paralogs for KIAA1841 Gene

No data available for Paralogs for KIAA1841 Gene

Variants for KIAA1841 Gene

Additional dbSNP identifiers (rs#s) for KIAA1841 Gene

Structural Variations from Database of Genomic Variants (DGV) for KIAA1841 Gene

Variant ID Type Subtype PubMed ID
esv2760616 CNV loss 21179565
nsv1116381 CNV deletion 24896259
nsv1131468 CNV deletion 24896259

Variation tolerance for KIAA1841 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1841 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1841

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIAA1841 Gene

Disorders for KIAA1841 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIAA1841 Gene - From: DISEASES

Disorder Aliases PubMed IDs
peroxisome biogenesis disorder 11a
  • pbd11a
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KIAA1841

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIAA1841: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIAA1841 Gene

Publications for KIAA1841 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  3. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 54

Products for KIAA1841 Gene

Sources for KIAA1841 Gene