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Aliases for KIAA1586 Gene

Aliases for KIAA1586 Gene

  • KIAA1586 2 3
  • EC 6.3.2.- 4

External Ids for KIAA1586 Gene

Previous GeneCards Identifiers for KIAA1586 Gene

  • GC06P056918
  • GC06P056958
  • GC06P057019
  • GC06P056745
  • GC06P056911

Summaries for KIAA1586 Gene

GeneCards Summary for KIAA1586 Gene

KIAA1586 (KIAA1586) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for KIAA1586 Gene

  • E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).

Additional gene information for KIAA1586 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1586 Gene

Genomics for KIAA1586 Gene

GeneHancer (GH) Regulatory Elements for KIAA1586 Gene

Promoters and enhancers for KIAA1586 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I057045 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 565.3 +0.5 456 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KIAA1586 GC06M057041 PRIM2 BEND6 ZNF451 BAG2 LOC101927211 ENSG00000272316 PIR59769
GH06I057171 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.5 +127.3 127278 5 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 BAG2 LOC101927211 KIAA1586 ZNF451 PRIM2 LINC00680
GH06I056765 Enhancer 1.3 Ensembl ENCODE dbSUPER 39.8 -279.4 -279369 2.8 PKNOX1 ZFP64 BATF RAD21 ZNF213 ZNF354C ATF7 ETV6 FOS BCLAF1 ZNF451 KIAA1586 PRIM2 LOC101927211 BEND6 LOC101930010 RAB23 DST GC06M056744 GC06P056805
GH06I057089 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.7 +43.7 43670 2.4 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC06M057088 ZNF451 BEND6 KIAA1586 PRIM2
GH06I056367 Enhancer 1.4 Ensembl ENCODE dbSUPER 23.8 -676.0 -675992 5.5 MLX ARID4B FEZF1 ZNF2 IRF4 ZNF48 ETS1 YY1 ZNF213 RUNX3 KIAA1586 ZNF451 DST PIR32262 COL21A1 ENSG00000227602
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIAA1586 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIAA1586 gene promoter:

Genomic Locations for KIAA1586 Gene

Genomic Locations for KIAA1586 Gene
chr6:57,046,532-57,059,326
(GRCh38/hg38)
Size:
12,795 bases
Orientation:
Plus strand
chr6:56,911,347-56,920,023
(GRCh37/hg19)

Genomic View for KIAA1586 Gene

Genes around KIAA1586 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1586 Gene

Proteins for KIAA1586 Gene

  • Protein details for KIAA1586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI6-K1586_HUMAN
    Recommended name:
    E3 SUMO-protein ligase KIAA1586
    Protein Accession:
    Q9HCI6
    Secondary Accessions:
    • A8K4M3
    • Q8IW25

    Protein attributes for KIAA1586 Gene

    Size:
    787 amino acids
    Molecular mass:
    89673 Da
    Quaternary structure:
    • Interacts with UBE2I/UBC9 and SUMO2.
    SequenceCaution:
    • Sequence=BAB13412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1586 Gene

Post-translational modifications for KIAA1586 Gene

  • Ubiquitination at isoforms=2275
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1586 Gene

No data available for DME Specific Peptides for KIAA1586 Gene

Domains & Families for KIAA1586 Gene

Gene Families for KIAA1586 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1586 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1586 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCI6

UniProtKB/Swiss-Prot:

K1586_HUMAN :
  • Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
Domain:
  • Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
genes like me logo Genes that share domains with KIAA1586: view

Function for KIAA1586 Gene

Molecular function for KIAA1586 Gene

UniProtKB/Swiss-Prot Function:
E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).

Enzyme Numbers (IUBMB) for KIAA1586 Gene

Gene Ontology (GO) - Molecular Function for KIAA1586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0061665 SUMO ligase activity IDA 26524493
genes like me logo Genes that share ontologies with KIAA1586: view

Phenotypes for KIAA1586 Gene

genes like me logo Genes that share phenotypes with KIAA1586: view

Animal Model Products

CRISPR Products

miRNA for KIAA1586 Gene

miRTarBase miRNAs that target KIAA1586

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1586 Gene

Localization for KIAA1586 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1586 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1586 Gene

Pathways & Interactions for KIAA1586 Gene

SuperPathways for KIAA1586 Gene

No Data Available

UniProtKB/Swiss-Prot Q9HCI6-K1586_HUMAN

  • Pathway: Protein modification; protein sumoylation.

Interacting Proteins for KIAA1586 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359768%0d%0a9606.ENSP00000237201%0d%0a
Selected Interacting proteins: Q9HCI6-K1586_HUMAN ENSP00000359768 for KIAA1586 Gene via IID STRING

Gene Ontology (GO) - Biological Process for KIAA1586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation IEA --
genes like me logo Genes that share ontologies with KIAA1586: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1586 Gene

Drugs & Compounds for KIAA1586 Gene

No Compound Related Data Available

Transcripts for KIAA1586 Gene

Unigene Clusters for KIAA1586 Gene

KIAA1586:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1586 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for KIAA1586 Gene

GeneLoc Exon Structure for
KIAA1586
ECgene alternative splicing isoforms for
KIAA1586

Expression for KIAA1586 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1586 Gene

Protein differential expression in normal tissues from HIPED for KIAA1586 Gene

This gene is overexpressed in Fetal heart (20.1), Fetal Brain (12.0), Urinary Bladder (6.9), CD4 Tcells (6.5), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA1586 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA1586 Gene:

KIAA1586

SOURCE GeneReport for Unigene cluster for KIAA1586 Gene:

Hs.709521

Evidence on tissue expression from TISSUES for KIAA1586 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with KIAA1586: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1586 Gene

Orthologs for KIAA1586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KIAA1586 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1586 33 34
  • 99.29 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1586 34
  • 68 (a)
OneToOne
Species where no ortholog for KIAA1586 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIAA1586 Gene

ENSEMBL:
Gene Tree for KIAA1586 (if available)
TreeFam:
Gene Tree for KIAA1586 (if available)

Paralogs for KIAA1586 Gene

(1) SIMAP similar genes for KIAA1586 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KIAA1586 Gene

genes like me logo Genes that share paralogs with KIAA1586: view

No data available for Paralogs for KIAA1586 Gene

Variants for KIAA1586 Gene

Sequence variations from dbSNP and Humsavar for KIAA1586 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000117532 -- 57,052,024(+) G/A intron_variant
rs1000326687 -- 57,046,464(+) G/A upstream_transcript_variant
rs1000614937 -- 57,048,551(+) T/C intron_variant
rs1001108755 -- 57,047,039(+) C/T intron_variant
rs1002185308 -- 57,046,531(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1586 Gene

Variant ID Type Subtype PubMed ID
dgv1780e212 CNV loss 25503493
dgv1781e212 CNV gain 25503493
esv2669750 CNV deletion 23128226
esv2732127 CNV deletion 23290073
esv2763988 CNV loss 21179565
esv3609110 CNV loss 21293372
esv3609111 CNV gain 21293372
esv3609112 CNV loss 21293372
esv3890849 CNV loss 25118596
nsv526143 CNV loss 19592680
nsv603189 CNV loss 21841781
nsv970717 CNV duplication 23825009

Variation tolerance for KIAA1586 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.28; 85.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1586 Gene

Human Gene Mutation Database (HGMD)
KIAA1586
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1586 Gene

Disorders for KIAA1586 Gene

Additional Disease Information for KIAA1586

No disorders were found for KIAA1586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1586 Gene

Publications for KIAA1586 Gene

  1. A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. (PMID: 26524493) Eisenhardt N … Pichler A (Nature structural & molecular biology 2015) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for KIAA1586 Gene

Sources for KIAA1586 Gene

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