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Aliases for KIAA1551 Gene

Aliases for KIAA1551 Gene

  • KIAA1551 2 3
  • Gonad Expressed Transcript 2 3
  • C12orf35 3 4
  • Chromosome 12 Open Reading Frame 35 2
  • Uncharacterized Protein C12orf35 3
  • Uncharacterized Protein KIAA1551 3
  • UTA2-1 3
  • GET 3

External Ids for KIAA1551 Gene

Previous HGNC Symbols for KIAA1551 Gene

  • C12orf35

Previous GeneCards Identifiers for KIAA1551 Gene

  • GC12P032113

Summaries for KIAA1551 Gene

GeneCards Summary for KIAA1551 Gene

KIAA1551 (KIAA1551) is a Protein Coding gene.

Additional gene information for KIAA1551 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1551 Gene

Genomics for KIAA1551 Gene

GeneHancer (GH) Regulatory Elements for KIAA1551 Gene

Promoters and enhancers for KIAA1551 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J031958 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 661.4 +1.5 1512 5.3 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CBX5 ZNF213 KIAA1551 LOC105369725 DDX11-AS1 LOC102724618
GH12J031316 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.4 -637.3 -637315 10.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SINHCAF IPO8 DDX11 FLJ13224 KIAA1551 LOC100422352 H3F3C DENND5B-AS1 DENND5B RNU5F-4P
GH12J031726 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.1 -230.9 -230893 3.9 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 GC12P031730 ENSG00000276900 AMN1 DDX11 LOC100420981 SINHCAF FLJ13224 KIAA1551 DDX11-AS1 CAPRIN2
GH12J031658 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.6 -299.9 -299928 2.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 ETFBKMT KIAA1551 DDX11 SINHCAF FLJ13224 IPO8 AK4P3 DSPA2D GC12P031714
GH12J031905 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 28.3 -52.8 -52801 2.1 SOX13 EBF1 CEBPG KLF5 ZNF280A CBX5 POLR2A ZNF143 TRIM24 IKZF2 KIAA1551 AMN1 LINC02422 H3F3C RPLP2P4 GC12M031929
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA1551 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KIAA1551 Gene

Genomic Locations for KIAA1551 Gene
chr12:31,959,370-31,993,107
(GRCh38/hg38)
Size:
33,738 bases
Orientation:
Plus strand
chr12:32,112,304-32,146,041
(GRCh37/hg19)
Size:
33,738 bases
Orientation:
Plus strand

Genomic View for KIAA1551 Gene

Genes around KIAA1551 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1551 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1551 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1551 Gene

Proteins for KIAA1551 Gene

  • Protein details for KIAA1551 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCM1-K1551_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1551
    Protein Accession:
    Q9HCM1
    Secondary Accessions:
    • B2RTU5
    • Q4KN17
    • Q9NVL6
    • Q9NWP9

    Protein attributes for KIAA1551 Gene

    Size:
    1747 amino acids
    Molecular mass:
    194857 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91330.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91734.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13377.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for KIAA1551 Gene

Post-translational modifications for KIAA1551 Gene

  • Ubiquitination at isoforms=815, Lys793, Lys777, Lys772, Lys658, isoforms=576, Lys450, Lys442, Lys404, isoforms=398, isoforms=390, isoforms=341, Lys299, Lys275, Lys233, isoforms=204, and isoforms=8
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1551 Gene

No data available for DME Specific Peptides for KIAA1551 Gene

Domains & Families for KIAA1551 Gene

Gene Families for KIAA1551 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1551 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1551: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1551 Gene

Function for KIAA1551 Gene

Phenotypes From GWAS Catalog for KIAA1551 Gene

genes like me logo Genes that share phenotypes with KIAA1551: view

Animal Model Products

CRISPR Products

miRNA for KIAA1551 Gene

miRTarBase miRNAs that target KIAA1551

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1551

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1551 Gene

Localization for KIAA1551 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1551 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Intermediate filaments (3)
  • Nucleoli (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1551 Gene

Pathways & Interactions for KIAA1551 Gene

SuperPathways for KIAA1551 Gene

No Data Available

Interacting Proteins for KIAA1551 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310338%0d%0a9606.ENSP00000417281%0d%0a9606.ENSP00000326514%0d%0a
Selected Interacting proteins: ENSP00000310338 Q9HCM1-K1551_HUMAN for KIAA1551 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KIAA1551 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1551 Gene

Drugs & Compounds for KIAA1551 Gene

No Compound Related Data Available

Transcripts for KIAA1551 Gene

Unigene Clusters for KIAA1551 Gene

KIAA1551:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1551

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1551 Gene

No ASD Table

Relevant External Links for KIAA1551 Gene

GeneLoc Exon Structure for
KIAA1551
ECgene alternative splicing isoforms for
KIAA1551

Expression for KIAA1551 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1551 Gene

mRNA differential expression in normal tissues according to GTEx for KIAA1551 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for KIAA1551 Gene

This gene is overexpressed in Plasma (58.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA1551 Gene



Protein tissue co-expression partners for KIAA1551 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1551 Gene:

KIAA1551

SOURCE GeneReport for Unigene cluster for KIAA1551 Gene:

Hs.445129

Evidence on tissue expression from TISSUES for KIAA1551 Gene

  • Spleen(2.1)
genes like me logo Genes that share expression patterns with KIAA1551: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1551 Gene

Orthologs for KIAA1551 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1551 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1551 34 33
  • 99.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf35 33
  • 78.33 (n)
KIAA1551 34
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C27H12orf35 33
  • 78.2 (n)
KIAA1551 34
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2810474O19Rik 16 34 33
  • 70.52 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309621 33
  • 69.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1551 34
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1551 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1551 34
  • 19 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1551 34
  • 17 (a)
OneToOne
Species where no ortholog for KIAA1551 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIAA1551 Gene

ENSEMBL:
Gene Tree for KIAA1551 (if available)
TreeFam:
Gene Tree for KIAA1551 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIAA1551: view image

Paralogs for KIAA1551 Gene

Pseudogenes.org Pseudogenes for KIAA1551 Gene

genes like me logo Genes that share paralogs with KIAA1551: view

No data available for Paralogs for KIAA1551 Gene

Variants for KIAA1551 Gene

Sequence variations from dbSNP and Humsavar for KIAA1551 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000130362 -- 31,979,275(+) C/A intron_variant
rs1000292032 -- 31,983,883(+) G/A coding_sequence_variant, synonymous_variant
rs1000314442 -- 31,978,416(+) C/T intron_variant
rs1000350362 -- 31,978,125(+) T/C intron_variant
rs1000503934 -- 31,979,126(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1551 Gene

Variant ID Type Subtype PubMed ID
nsv558100 CNV gain 21841781

Variation tolerance for KIAA1551 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.40; 92.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1551 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1551

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1551 Gene

Disorders for KIAA1551 Gene

Additional Disease Information for KIAA1551

No disorders were found for KIAA1551 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1551 Gene

Publications for KIAA1551 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1. (PMID: 23079962) Oostvogels R … Mutis T (Leukemia 2013) 2 3 58
  3. Conserved expression of a novel gene during gonadal development. (PMID: 15861396) Hudson QJ … Sinclair AH (Developmental dynamics : an official publication of the American Association of Anatomists 2005) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for KIAA1551 Gene

Sources for KIAA1551 Gene

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