Aliases for KIAA1522 Gene

Aliases for KIAA1522 Gene

  • KIAA1522 2 3
  • Uncharacterized Protein KIAA1522 3 4

External Ids for KIAA1522 Gene

Previous GeneCards Identifiers for KIAA1522 Gene

  • GC01P033050
  • GC01P032186
  • GC01P032658
  • GC01P032888
  • GC01P032980
  • GC01P033207
  • GC01P031322

Summaries for KIAA1522 Gene

GeneCards Summary for KIAA1522 Gene

KIAA1522 (KIAA1522) is a Protein Coding gene. An important paralog of this gene is NHSL1.

Additional gene information for KIAA1522 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIAA1522 Gene

Genomics for KIAA1522 Gene

GeneHancer (GH) Regulatory Elements for KIAA1522 Gene

Promoters and enhancers for KIAA1522 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J032740 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.9 880 4.2 HNRNPK CTCF POLR2G ZFX ZIC2 ZBTB10 ZNF423 ZBTB26 UBTF REST KIAA1522 RBBP4 KPNA6 KHDRBS1 SYNC lnc-SYNC-4
GH01J032763 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 513.3 +24.2 24225 4.3 USF1 ZIC2 HDAC2 POLR2A KLF9 ZBTB17 PHF8 ZFHX2 FOXA1 PAX8 KIAA1522 FNDC5 S100PBP ENSG00000224409 SYNC YARS1 lnc-SYNC-4
GH01J032715 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15 -24.7 -24748 3 EP300 POLR2G NCOR1 KDM6A KLF4 RFX1 ZBTB25 TOE1 MYC CTBP1 KIAA1522 TMEM54 ENSG00000224409 RF00017-153
GH01J032711 Enhancer 1.2 ENCODE dbSUPER 12.3 -29.4 -29425 1.1 CTCF NRF1 ZIC2 ZBTB10 ZBTB26 TRIM28 TARDBP REST ZBTB25 MYC KIAA1522 ZSCAN20 FNDC5 ZBTB8A SYNC TMEM54 RF00017-153 ENSG00000224409
GH01J032771 Enhancer 1.1 ENCODE dbSUPER 13 +32.3 32288 5.1 CTCF POLR2G JUND ZNF639 GABPA TARDBP REST DNMT1 RAD21 CTBP1 FNDC5 KIAA1522 ENSG00000224409 SYNC S100PBP YARS1 RBBP4 ZBTB8OS ENSG00000233775 lnc-SYNC-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA1522 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIAA1522

Top Transcription factor binding sites by QIAGEN in the KIAA1522 gene promoter:
  • E47
  • FOXI1
  • HFH-3
  • LyF-1
  • Nkx5-1
  • RelA
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta

Genomic Locations for KIAA1522 Gene

Genomic Locations for KIAA1522 Gene
chr1:32,741,830-32,774,970
(GRCh38/hg38)
Size:
33,141 bases
Orientation:
Plus strand
chr1:33,207,486-33,240,571
(GRCh37/hg19)
Size:
33,086 bases
Orientation:
Plus strand

Genomic View for KIAA1522 Gene

Genes around KIAA1522 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1522 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1522 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1522 Gene

Proteins for KIAA1522 Gene

  • Protein details for KIAA1522 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P206-K1522_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1522
    Protein Accession:
    Q9P206
    Secondary Accessions:
    • B4DQU8
    • B5MDY0
    • C9JH84
    • Q8TCQ0

    Protein attributes for KIAA1522 Gene

    Size:
    1035 amino acids
    Molecular mass:
    107095 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96046.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1522 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1522 Gene

Post-translational modifications for KIAA1522 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1522 Gene

Domains & Families for KIAA1522 Gene

Gene Families for KIAA1522 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1522 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1522 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60810 (B4DQU8_HUMAN)
genes like me logo Genes that share domains with KIAA1522: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KIAA1522 Gene

Function for KIAA1522 Gene

Phenotypes From GWAS Catalog for KIAA1522 Gene

Phenotypes for KIAA1522 Gene

GenomeRNAi human phenotypes for KIAA1522:
genes like me logo Genes that share phenotypes with KIAA1522: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1522

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1522 Gene

Localization for KIAA1522 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1522 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1522 Gene

Pathways & Interactions for KIAA1522 Gene

PathCards logo

SuperPathways for KIAA1522 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1522 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IBA 21873635
genes like me logo Genes that share ontologies with KIAA1522: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1522 Gene

Drugs & Compounds for KIAA1522 Gene

No Compound Related Data Available

Transcripts for KIAA1522 Gene

mRNA/cDNA for KIAA1522 Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1522

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1522 Gene

No ASD Table

Relevant External Links for KIAA1522 Gene

GeneLoc Exon Structure for
KIAA1522

Expression for KIAA1522 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1522 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1522 Gene

This gene is overexpressed in Adrenal Gland (x4.0).

Protein differential expression in normal tissues from HIPED for KIAA1522 Gene

This gene is overexpressed in Lung (24.1), Placenta (17.4), and Pancreas (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA1522 Gene



Protein tissue co-expression partners for KIAA1522 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIAA1522

SOURCE GeneReport for Unigene cluster for KIAA1522 Gene:

Hs.591502

Evidence on tissue expression from TISSUES for KIAA1522 Gene

  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with KIAA1522: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1522 Gene

Orthologs for KIAA1522 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1522 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1522 31 30
  • 99.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1522 31 30
  • 85.32 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1522 31
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1522 30
  • 84.02 (n)
mouse
(Mus musculus)
Mammalia C77080 17 31 30
  • 81.99 (n)
rat
(Rattus norvegicus)
Mammalia RGD1561149 30
  • 81.4 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1522 31
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1522 31
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1522 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1522 30
  • 54.56 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-194e15.5 31
  • 26 (a)
OneToMany
si:dkey-157l19.2 31
  • 23 (a)
OneToMany
Species where no ortholog for KIAA1522 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1522 Gene

ENSEMBL:
Gene Tree for KIAA1522 (if available)
TreeFam:
Gene Tree for KIAA1522 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIAA1522: view image

Paralogs for KIAA1522 Gene

Paralogs for KIAA1522 Gene

genes like me logo Genes that share paralogs with KIAA1522: view

Variants for KIAA1522 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIAA1522 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
773394 Benign: not provided 32,769,668(+) C/A INTRON_VARIANT
rs11582639 - p.Leu310Ile
rs11803515 - p.Pro57Ser
rs12730560 - p.Met232Val
rs3737994 - p.Ser114Pro

Additional dbSNP identifiers (rs#s) for KIAA1522 Gene

Structural Variations from Database of Genomic Variants (DGV) for KIAA1522 Gene

Variant ID Type Subtype PubMed ID
esv2657788 CNV deletion 23128226
esv2664118 CNV deletion 23128226
esv2746552 CNV deletion 23290073
esv2746563 CNV deletion 23290073
esv3585676 CNV loss 21293372
nsv1075410 CNV deletion 25765185
nsv1143445 CNV deletion 24896259
nsv322 CNV deletion 18451855
nsv509158 CNV insertion 20534489
nsv519188 CNV loss 19592680

Variation tolerance for KIAA1522 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1522 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1522

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1522 Gene

Disorders for KIAA1522 Gene

Additional Disease Information for KIAA1522

No disorders were found for KIAA1522 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1522 Gene

Publications for KIAA1522 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer. (PMID: 27098511) Liu YZ … Wang MR (Scientific reports 2016) 2 3 54
  3. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 54
  4. CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI. (PMID: 31240132) Hu WF … Woods NT (Cell death discovery 2019) 3 54
  5. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3 54

Products for KIAA1522 Gene

Sources for KIAA1522 Gene