Aliases for KIAA1328 Gene

Aliases for KIAA1328 Gene

  • KIAA1328 2 3 5
  • Protein Hinderin 3 4
  • Hinderin 2 3

External Ids for KIAA1328 Gene

Previous GeneCards Identifiers for KIAA1328 Gene

  • GC18P034483
  • GC18P034232
  • GC18P032661
  • GC18P032663
  • GC18P031267

Summaries for KIAA1328 Gene

GeneCards Summary for KIAA1328 Gene

KIAA1328 (KIAA1328) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for KIAA1328 Gene

  • Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIAA1328 Gene

Genomics for KIAA1328 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIAA1328 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J036827 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 262.8 +0.1 84 3.4 CHD2 TBP SP1 ZBTB10 MXD4 SIX5 NR2C1 MNT IKZF1 SMAD5 TPGS2 KIAA1328 lnc-CELF4-11 ENSG00000267707 ELP2 lnc-TPGS2-2
GH18J036830 Enhancer 0.2 ENCODE 250.7 +2.0 1992 0.1 KIAA1328 TPGS2 lnc-CELF4-11 lnc-TPGS2-2 CELF4
GH18J036127 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 -698.5 -698450 5.5 TBP ZBTB10 SP1 MXD4 CEBPA NR2C1 MNT IKZF1 SMAD5 ETS1 ELP2 SLC39A6 ENSG00000268573 ZNF397 KIAA1328 COSMOC MOCOS ENSG00000267404 HSALNG0120935
GH18J037449 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +623.1 623107 5.4 ELF1 CEBPB ZNF623 ZNF585B STAT3 MAZ RFX1 RCOR1 SP1 GATA2 KIAA1328 CELF4 HSALNG0120988 SNORA111 HSALNG0120986 TPGS2
GH18J036479 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.8 -347.0 -347016 5.6 FEZF1 ZIC2 SIN3A REST CTBP1 ZNF843 KLF16 ZFP37 FOXA1 ZNF24 HSALNG0120956 ENSG00000267707 RPRD1A ELP2 KIAA1328 ENSG00000267404 piR-61101-319 FHOD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA1328 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIAA1328

Top Transcription factor binding sites by QIAGEN in the KIAA1328 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • HSF1 (long)
  • HSF1short
  • Nkx5-1
  • Pax-3
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KIAA1328 Gene

Latest Assembly
403,356 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
403,046 bases
Plus strand

(GRCh37/hg19 by Ensembl)
403,067 bases
Plus strand

Genomic View for KIAA1328 Gene

Genes around KIAA1328 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1328 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1328 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1328 Gene

Proteins for KIAA1328 Gene

  • Protein details for KIAA1328 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein hinderin
    Protein Accession:
    Secondary Accessions:
    • Q05DL0
    • Q49AG6
    • Q9P2L8

    Protein attributes for KIAA1328 Gene

    577 amino acids
    Molecular mass:
    65373 Da
    Quaternary structure:
    • Interacts (via N- and C-terminal domains) with SMC3 (via central hinge region).
    • Sequence=BAA92566.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1328 Gene


neXtProt entry for KIAA1328 Gene

Post-translational modifications for KIAA1328 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1328 Gene

Domains & Families for KIAA1328 Gene

Gene Families for KIAA1328 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1328 Gene

genes like me logo Genes that share domains with KIAA1328: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KIAA1328 Gene

Function for KIAA1328 Gene

Molecular function for KIAA1328 Gene

UniProtKB/Swiss-Prot Function:
Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.

Phenotypes From GWAS Catalog for KIAA1328 Gene

Gene Ontology (GO) - Molecular Function for KIAA1328 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15656913
genes like me logo Genes that share ontologies with KIAA1328: view

Phenotypes for KIAA1328 Gene

genes like me logo Genes that share phenotypes with KIAA1328: view

miRNA for KIAA1328 Gene

miRTarBase miRNAs that target KIAA1328

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1328

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1328 Gene

Localization for KIAA1328 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1328 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
  • Nuclear speckles (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1328 Gene

Pathways & Interactions for KIAA1328 Gene

PathCards logo

SuperPathways for KIAA1328 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1328 Gene


No data available for Pathways by source and SIGNOR curated interactions for KIAA1328 Gene

Drugs & Compounds for KIAA1328 Gene

No Compound Related Data Available

Transcripts for KIAA1328 Gene

mRNA/cDNA for KIAA1328 Gene

9 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1328

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1328 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: -

Relevant External Links for KIAA1328 Gene

GeneLoc Exon Structure for

Expression for KIAA1328 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1328 Gene

Protein differential expression in normal tissues from HIPED for KIAA1328 Gene

This gene is overexpressed in NK cells (28.6), Bone marrow mesenchymal stem cell (26.6), and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1328 Gene

Protein tissue co-expression partners for KIAA1328 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIAA1328

SOURCE GeneReport for Unigene cluster for KIAA1328 Gene:


mRNA Expression by UniProt/SwissProt for KIAA1328 Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with KIAA1328: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1328 Gene

Orthologs for KIAA1328 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1328 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA1328 30 31
  • 99.31 (n)
(Canis familiaris)
Mammalia KIAA1328 30 31
  • 85.47 (n)
(Bos Taurus)
Mammalia KIAA1328 30 31
  • 85.04 (n)
(Mus musculus)
Mammalia AW554918 30 17 31
  • 81.18 (n)
(Rattus norvegicus)
Mammalia RGD1562608 30
  • 80.09 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
-- 31
  • 44 (a)
(Monodelphis domestica)
Mammalia KIAA1328 31
  • 49 (a)
(Gallus gallus)
Aves KIAA1328 30 31
  • 59.79 (n)
(Anolis carolinensis)
Reptilia KIAA1328 31
  • 68 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kiaa1328 30
  • 59.03 (n)
(Danio rerio)
Actinopterygii zgc:162344 30 31
  • 48.27 (n)
-- 30
Species where no ortholog for KIAA1328 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KIAA1328 Gene

Gene Tree for KIAA1328 (if available)
Gene Tree for KIAA1328 (if available)
Evolutionary constrained regions (ECRs) for KIAA1328: view image

Paralogs for KIAA1328 Gene Pseudogenes for KIAA1328 Gene

genes like me logo Genes that share paralogs with KIAA1328: view

No data available for Paralogs for KIAA1328 Gene

Variants for KIAA1328 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIAA1328 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs201927424 Benign: not provided 36,885,549(+) T/A
rs769042456 Benign: not provided 36,829,157(+) C/T
NM_020776.3(KIAA1328):c.19C>T (p.Pro7Ser)
rs12326301 - p.Arg383Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KIAA1328 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KIAA1328 Gene

Variant ID Type Subtype PubMed ID
dgv3334n100 CNV loss 25217958
dgv3335n100 CNV loss 25217958
esv2140858 CNV deletion 18987734
esv2658205 CNV deletion 23128226
esv2659277 CNV deletion 23128226
esv2671487 CNV deletion 23128226
esv2672898 CNV deletion 23128226
esv2716963 CNV deletion 23290073
esv2716964 CNV deletion 23290073
esv2716965 CNV deletion 23290073
esv27487 CNV loss 19812545
esv2758722 CNV gain 17122850
esv34228 CNV gain 17911159
esv3583013 CNV loss 25503493
esv3583016 CNV loss 25503493
esv3642236 CNV loss 21293372
esv3642237 CNV gain 21293372
esv3642239 CNV loss 21293372
esv3642240 CNV loss 21293372
esv3642243 CNV loss 21293372
esv3642244 CNV loss 21293372
esv3642245 CNV gain 21293372
nsv1059177 CNV gain 25217958
nsv1059592 CNV loss 25217958
nsv1060521 CNV loss 25217958
nsv1062166 CNV loss 25217958
nsv1071455 CNV deletion 25765185
nsv2257 CNV insertion 18451855
nsv2258 CNV deletion 18451855
nsv438283 CNV loss 16468122
nsv478167 CNV novel sequence insertion 20440878
nsv576651 CNV loss 21841781
nsv576653 CNV loss 21841781
nsv817789 CNV gain 17921354
nsv833621 CNV loss 17160897

Variation tolerance for KIAA1328 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1328 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1328 Gene

Disorders for KIAA1328 Gene

Additional Disease Information for KIAA1328

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for KIAA1328 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1328 Gene

Publications for KIAA1328 Gene

  1. Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. (PMID: 15656913) Patel CA … Ghiselli G (BMC cell biology 2005) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  5. Familial 18q12.2 deletion supports the role of RNA-binding protein CELF4 in autism spectrum disorders. (PMID: 28407444) Barone R … Rizzo R (American journal of medical genetics. Part A 2017) 3

Products for KIAA1328 Gene

Sources for KIAA1328 Gene