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Aliases for KIAA1211L Gene

Aliases for KIAA1211L Gene

  • KIAA1211 Like 2 3 5
  • C2orf55 3 4
  • Uncharacterized Protein KIAA1211-Like 3
  • Chromosome 2 Open Reading Frame 55 2
  • Uncharacterized Protein C2orf55 3

External Ids for KIAA1211L Gene

Previous HGNC Symbols for KIAA1211L Gene

  • C2orf55

Previous GeneCards Identifiers for KIAA1211L Gene

  • GC02M099411

Summaries for KIAA1211L Gene

GeneCards Summary for KIAA1211L Gene

KIAA1211L (KIAA1211 Like) is a Protein Coding gene. An important paralog of this gene is KIAA1211.

Additional gene information for KIAA1211L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1211L Gene

Genomics for KIAA1211L Gene

GeneHancer (GH) Regulatory Elements for KIAA1211L Gene

Promoters and enhancers for KIAA1211L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J098935 Promoter/Enhancer 1.6 EPDnew Ensembl dbSUPER 650.7 +0.1 58 0.8 CTCF FEZF1 HIC1 ZNF335 ZFHX2 ZNF524 ZFX PRDM1 ZBTB26 ZBTB20 KIAA1211L RNU7-46P
GH02J098851 Promoter 0.5 EPDnew 650.2 +84.8 84810 0.1 KIAA1211L RNU4-84P MGAT4A TSGA10 RNU7-46P
GH02J098911 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.9 +23.5 23543 2.4 DMAP1 ZNF48 RARA ZNF614 FOS THAP11 NFKBIZ EGR2 MXD4 MIER2 KIAA1211L TSGA10 REV1 RNU7-46P
GH02J098908 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +26.9 26914 2.1 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF48 ZNF202 NFYC MXD4 LOC550644 ENSG00000273306 UNC50 REV1 MITD1 TMEM131 LIPT1 KIAA1211L RNU7-46P
GH02J098874 Enhancer 0.7 dbSUPER 18.4 +61.0 61005 1.9 PKNOX1 STAT5A BATF IRF4 POLR2A NFATC1 EED ETV6 BCLAF1 IKZF2 KIAA1211L RNU7-46P TSGA10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA1211L on UCSC Golden Path with GeneCards custom track

Genomic Locations for KIAA1211L Gene

Genomic Locations for KIAA1211L Gene
chr2:98,793,846-98,936,259
(GRCh38/hg38)
Size:
142,414 bases
Orientation:
Minus strand
chr2:99,410,309-99,552,722
(GRCh37/hg19)
Size:
142,414 bases
Orientation:
Minus strand

Genomic View for KIAA1211L Gene

Genes around KIAA1211L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1211L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1211L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1211L Gene

Proteins for KIAA1211L Gene

  • Protein details for KIAA1211L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NV74-K121L_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1211-like
    Protein Accession:
    Q6NV74

    Protein attributes for KIAA1211L Gene

    Size:
    962 amino acids
    Molecular mass:
    102157 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH68277.1; Type=Frameshift; Positions=503, 725; Evidence={ECO:0000305};

neXtProt entry for KIAA1211L Gene

Post-translational modifications for KIAA1211L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1211L Gene

Domains & Families for KIAA1211L Gene

Gene Families for KIAA1211L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1211L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1211L: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1211L Gene

Function for KIAA1211L Gene

Phenotypes From GWAS Catalog for KIAA1211L Gene

genes like me logo Genes that share phenotypes with KIAA1211L: view

Animal Models for KIAA1211L Gene

MGI Knock Outs for KIAA1211L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1211L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KIAA1211L Gene

Localization for KIAA1211L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1211L gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1211L Gene

Pathways & Interactions for KIAA1211L Gene

SuperPathways for KIAA1211L Gene

No Data Available

Interacting Proteins for KIAA1211L Gene

Selected Interacting proteins: Q6NV74-K121L_HUMAN for KIAA1211L Gene via IID

Symbol External ID(s) Details
NRAP
YWHAE

Gene Ontology (GO) - Biological Process for KIAA1211L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1211L Gene

Drugs & Compounds for KIAA1211L Gene

No Compound Related Data Available

Transcripts for KIAA1211L Gene

mRNA/cDNA for KIAA1211L Gene

Unigene Clusters for KIAA1211L Gene

KIAA1211-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1211L

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1211L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3:
SP4: - - - -
SP5:

Relevant External Links for KIAA1211L Gene

GeneLoc Exon Structure for
KIAA1211L
ECgene alternative splicing isoforms for
KIAA1211L

Expression for KIAA1211L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1211L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1211L Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for KIAA1211L Gene

This gene is overexpressed in Frontal cortex (33.4) and Brain (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1211L Gene



Protein tissue co-expression partners for KIAA1211L Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1211L Gene:

KIAA1211L

SOURCE GeneReport for Unigene cluster for KIAA1211L Gene:

Hs.469398
genes like me logo Genes that share expression patterns with KIAA1211L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1211L Gene

Orthologs for KIAA1211L Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1211L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1211L 34 33
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1211L 33
  • 77.28 (n)
dog
(Canis familiaris)
Mammalia C10H2orf55 33
  • 76.94 (n)
KIAA1211L 34
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310819 33
  • 73.49 (n)
mouse
(Mus musculus)
Mammalia 2010300C02Rik 16 34 33
  • 71.82 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1211L 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KIAA1211L 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-149l1.2 34
  • 25 (a)
OneToMany
si:ch211-121j5.4 34
  • 17 (a)
OneToMany
Species where no ortholog for KIAA1211L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1211L Gene

ENSEMBL:
Gene Tree for KIAA1211L (if available)
TreeFam:
Gene Tree for KIAA1211L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIAA1211L: view image

Paralogs for KIAA1211L Gene

Paralogs for KIAA1211L Gene

genes like me logo Genes that share paralogs with KIAA1211L: view

Variants for KIAA1211L Gene

Sequence variations from dbSNP and Humsavar for KIAA1211L Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000001146 -- 98,912,255(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000007486 -- 98,926,883(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000012168 -- 98,843,667(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000049631 -- 98,892,583(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000091601 -- 98,824,909(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1211L Gene

Variant ID Type Subtype PubMed ID
esv1435269 CNV insertion 17803354
esv2277586 CNV deletion 18987734
esv3591730 CNV loss 21293372
nsv1071606 CNV deletion 25765185
nsv1114119 CNV deletion 24896259
nsv1133478 CNV deletion 24896259
nsv2842 CNV insertion 18451855
nsv582517 CNV loss 21841781
nsv582518 CNV loss 21841781
nsv834310 CNV gain+loss 17160897

Variation tolerance for KIAA1211L Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1211L Gene

Human Gene Mutation Database (HGMD)
KIAA1211L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1211L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1211L Gene

Disorders for KIAA1211L Gene

Additional Disease Information for KIAA1211L

No disorders were found for KIAA1211L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1211L Gene

Publications for KIAA1211L Gene

  1. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  3. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PMID: 19416921) Scott LJ … Boehnke M (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for KIAA1211L Gene

Sources for KIAA1211L Gene

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