Aliases for KIAA1210 Gene

Aliases for KIAA1210 Gene

  • KIAA1210 2 3 5
  • Acrosomal Protein KIAA1210 3 4

External Ids for KIAA1210 Gene

Previous GeneCards Identifiers for KIAA1210 Gene

  • GC0XM9G0175
  • GC0XM115198
  • GC0XM116188
  • GC0XM117994
  • GC0XM118097
  • GC0XM118212
  • GC0XM107704

Summaries for KIAA1210 Gene

GeneCards Summary for KIAA1210 Gene

KIAA1210 (KIAA1210) is a Protein Coding gene. An important paralog of this gene is SPOCK2.

Additional gene information for KIAA1210 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIAA1210 Gene

Genomics for KIAA1210 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIAA1210 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119149 Enhancer 0.2 Ensembl 600.7 -0.4 -418 0.2 KIAA1210 lnc-PGRMC1-2 RF00017-8642 PGRMC1
GH0XJ118839 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 +311.4 311436 1.3 HNRNPL GATAD2A CTCF TFE3 RBFOX2 RXRB REST SP1 ZNF501 POLR2A LINC01285 RF00017-8643 KIAA1210 ZCCHC12 LONRF3 RF00017-8642
GH0XJ119039 Enhancer 1 FANTOM5 ENCODE 11.8 +110.1 110109 3.1 ATF7 IKZF1 JUND RXRB NR2C1 ETV6 THRA EGR1 CTBP1 NFE2 piR-50444-505 LONRF3 KIAA1210 ENSG00000277535 LOC727838 RF00017-8642
GH0XJ119005 Enhancer 0.7 Ensembl ENCODE 11.3 +145.9 145941 0.5 CTCF JUND ZNF143 REST RAD21 TRIM22 SCRT2 SMC3 ZNF654 RB1 RF00017-8645 RF00017-8646 KIAA1210 LONRF3 ENSG00000277535 RF00017-8642
GH0XJ119189 Enhancer 0.6 Ensembl ENCODE 13.4 -39.3 -39284 2.6 CTCF YY1 POLR2A ZFP91 SMARCA4 KIAA1210 piR-31926-042 RF00017-8642 lnc-PGRMC1-2 PGRMC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA1210 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIAA1210

Top Transcription factor binding sites by QIAGEN in the KIAA1210 gene promoter:
  • AML1a
  • AP-1
  • c-Fos
  • c-Jun
  • Ik-1
  • LHX3b
  • NF-1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for KIAA1210 Gene

Genomic Locations for KIAA1210 Gene
chrX:119,078,635-119,151,083
(GRCh38/hg38)
Size:
72,449 bases
Orientation:
Minus strand
chrX:118,212,598-118,284,542
(GRCh37/hg19)
Size:
71,945 bases
Orientation:
Minus strand

Genomic View for KIAA1210 Gene

Genes around KIAA1210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1210 Gene

Proteins for KIAA1210 Gene

  • Protein details for KIAA1210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULL0-K1210_HUMAN
    Recommended name:
    Acrosomal protein KIAA1210
    Protein Accession:
    Q9ULL0
    Secondary Accessions:
    • B7ZCI8
    • Q5JPN4

    Protein attributes for KIAA1210 Gene

    Size:
    1709 amino acids
    Molecular mass:
    187021 Da
    Quaternary structure:
    • Interacts with TOP2B.

neXtProt entry for KIAA1210 Gene

Post-translational modifications for KIAA1210 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1210 Gene

No data available for DME Specific Peptides for KIAA1210 Gene

Domains & Families for KIAA1210 Gene

Gene Families for KIAA1210 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1210 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with KIAA1210: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KIAA1210 Gene

Function for KIAA1210 Gene

Phenotypes From GWAS Catalog for KIAA1210 Gene

genes like me logo Genes that share phenotypes with KIAA1210: view

Animal Model Products

CRISPR Products

miRNA for KIAA1210 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1210

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1210 Gene

Localization for KIAA1210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1210 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes to the sex body in spermatocyte, acrosome, and near the ectoplasmic specialization. {ECO:0000250 UniProtKB:E9Q0C6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1210 gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for KIAA1210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0061832 colocalizes_with basal ectoplasmic specialization ISS --
genes like me logo Genes that share ontologies with KIAA1210: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIAA1210 Gene

Pathways & Interactions for KIAA1210 Gene

PathCards logo

SuperPathways for KIAA1210 Gene

No Data Available

Interacting Proteins for KIAA1210 Gene

Gene Ontology (GO) - Biological Process for KIAA1210 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1210 Gene

Drugs & Compounds for KIAA1210 Gene

No Compound Related Data Available

Transcripts for KIAA1210 Gene

mRNA/cDNA for KIAA1210 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA1210

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1210 Gene

No ASD Table

Relevant External Links for KIAA1210 Gene

GeneLoc Exon Structure for
KIAA1210

Expression for KIAA1210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1210 Gene

This gene is overexpressed in Testis (x42.7).

Protein differential expression in normal tissues from HIPED for KIAA1210 Gene

This gene is overexpressed in Testis (36.7) and Ovary (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1210 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIAA1210

SOURCE GeneReport for Unigene cluster for KIAA1210 Gene:

Hs.97594

Evidence on tissue expression from TISSUES for KIAA1210 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with KIAA1210: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1210 Gene

Orthologs for KIAA1210 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KIAA1210 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIAA1210 30 31
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KIAA1210 30 31
  • 68.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KIAA1210 31
  • 36 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm14569 31
  • 28 (a)
OneToOne
Species where no ortholog for KIAA1210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KIAA1210 Gene

ENSEMBL:
Gene Tree for KIAA1210 (if available)
TreeFam:
Gene Tree for KIAA1210 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIAA1210: view image

Paralogs for KIAA1210 Gene

Paralogs for KIAA1210 Gene

genes like me logo Genes that share paralogs with KIAA1210: view

Variants for KIAA1210 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIAA1210 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
709325 Benign: not provided 119,096,546(-) C/T MISSENSE_VARIANT
715756 Benign: not provided 119,094,105(-) G/A INTRON_VARIANT
727512 Benign: not provided 119,087,808(-) C/T MISSENSE_VARIANT
728170 Likely Benign: not provided 119,116,524(-) C/T MISSENSE_VARIANT
764768 Likely Benign: not provided 119,108,347(-) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for KIAA1210 Gene

Structural Variations from Database of Genomic Variants (DGV) for KIAA1210 Gene

Variant ID Type Subtype PubMed ID
esv3574404 CNV loss 25503493

Variation tolerance for KIAA1210 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.61; 78.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1210 Gene

Human Gene Mutation Database (HGMD)
KIAA1210
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1210 Gene

Disorders for KIAA1210 Gene

Additional Disease Information for KIAA1210

No disorders were found for KIAA1210 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1210 Gene

Publications for KIAA1210 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Novel localizations and interactions of intercellular bridge proteins revealed by proteomic profiling†. (PMID: 31995159) Iwamori T … Ono E (Biology of reproduction 2020) 2 3
  3. Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes. (PMID: 28203736) Iwamori T … Matzuk MM (Biology of reproduction 2017) 2 3
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  5. Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. (PMID: 30097533) Schiza C … Diamandis EP (Molecular & cellular proteomics : MCP 2018) 3

Products for KIAA1210 Gene

Sources for KIAA1210 Gene